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Siglec-8

Siglec-8 詳細

英語名	Sialic acid-binding Ig-like lectin 8	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
研究＆開発段階	Phase 3 Clinical

英語名	Sialic acid-binding Ig-like lectin 8
ターゲットの別称	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 3 Clinical

Siglec-8 製品リスト

属性
Protein (3)
製品ライブラリ
オンライン (3)
種
Human (3)
タグ
His Tag (1)Fc Tag (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (2)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT SI8-H52H8	Human	HEK293	Human Siglec-8 Protein, His Tag, low endotoxin (MALS verified)
SI8-H5254	Human	HEK293	Human Siglec-8 Protein, Fc Tag
SI8-H82E9	Human	HEK293	Biotinylated Human Siglec-8 Protein, His,Avitag™

総数量3

Siglec-8バックグランド

Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8分子の別称

Siglec-8,SAF-2,SIGLEC8,SAF2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
AK-001	AK-001	Phase 3 Clinical	Allakos Inc	Community Acquired Pneumonia; Hypersensitivity; Nasal Polyps; Respiratory Tract Infections; Urinary Tract Infections	詳細