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SSTR2

SSTR2 詳細

英語名	Somatostatin receptor 2	市販薬剤の数	7
治験薬の数	27	ターゲットの別称	Somatostatin receptor type 2，SS-2-R，SS2R，SSTR2，Somatostatin Receptor 2，SRIF-1，SS2-R
研究＆開発段階	Approved

英語名	Somatostatin receptor 2
ターゲットの別称	Somatostatin receptor type 2，SS-2-R，SS2R，SSTR2，Somatostatin Receptor 2，SRIF-1，SS2-R
市販薬剤の数	7
治験薬の数	27
研究＆開発段階	Approved

SSTR2 製品リスト

属性
Protein (2)Cell (1)
製品ライブラリ
オンライン (3)
種
Human (3)
タグ
- (2)GFP Tag (1)
マーカー
Unconjugated (1)GFP Fusion (1)- (1)

製品番号	種	発現システム	製品説明
CHEK-ATP213	Human	HEK293	HEK293/Human SSTR2 Stable Cell Line
SS2-H5216	Human	HEK293	Human SSTR2 Full Length Protein (VLP)
SS2-HF2G3	Human	HEK293	Fluorescent Human SSTR2 Full Length Protein (VLP)

総数量3

SSTR2バックグランド

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors.

SSTR2分子の別称

Smstr2,Somatostatin R2,somatostatin receptor 2,somatostatin receptor type 2,SomatostatinR2,SRIF-1,SS2R,SS-2-R,SS2-R,SST2,SSTR2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Lutetium-177 labelled edotreotide	ITM-11	Phase 3 Clinical	Itm Solucin Gmbh, Universitaetsspitals Basel	Central Nervous System Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Lymphoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Carcinoma of Lung; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Rhabdomyosarcoma; Solid tumours; Thymus Neoplasms	詳細
Actinium-225 Dotate	225Ac-DOTATATE; RYZ-101; [225Ac]Ac-DOTATATE	Phase 3 Clinical	RayzeBio Inc	Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Gastroenteropancreatic neuroendocrine tumor; Meningioma; Metastatic breast cancer; Multiple Myeloma; Neuroendocrine Tumors; Small Cell Lung Carcinoma	詳細
Lutetium-177 DOTA satoreotide	OPS-201; 177LU-OPS 201; 177Lu-DOTA- JR11; 177Lu-satoreotide; 177Lu-IPN01072; [177Lu]LuSSO110; 177Lu-IPN-1072; 177Lu SSO 110	Phase 2 Clinical	OctreoPharm Sciences GmbH	Breast Neoplasms; Meningioma; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma	詳細
Yttrium 90-labelled edotreotide	SMT-487-[90Y]; DOTATOC-[90Y]	Phase 2 Clinical	Novartis Pharma Ag, The University Of Iowa	Adenoma, Islet Cell; Breast Neoplasms; Carcinoid Tumor; CNS Embryonal Tumor; Lung Neoplasms; Lymphoma; Medulloblastoma; Meningioma; Neoplasms; Neuroblastoma; Neuroendocrine Tumors; Pheochromocytoma; Sarcoma; Skin Melanoma; Solid tumours	詳細
ZT-01	ZT 01; ZT-01	Phase 2 Clinical	Tulane University, University Of Toronto, Toronto, York University	Diabetes Mellitus, Type 1; Hypoglycemia	詳細
Terbium 161 DOTATATE PRRT		Phase 2 Clinical	Tata Memorial Centre	Carcinoma, Neuroendocrine; Neuroendocrine Tumors	詳細
Al18F-NOTA-LM3	Al18F-NOTA-LM3	Phase 2 Clinical	Peking Union Medical College Hospital	Neuroendocrine Tumors	詳細
68Ga-HA-DOTATATE	68Ga-HA-DOTATATE	Phase 2 Clinical	University Of Alberta	Neuroendocrine Tumors	詳細
Re-188 P 2045	Rhenium-188 P2045; Rhenium-188-P-2045; Re-188 P 2045; Rh-188 P2045; Rhenium 188 P2045; P2045; BAY-865284	Phase 2 Clinical	Bayer AG	Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Lung Neoplasms; Neoplasm Recurrence, Local; Neuroendocrine Tumors; Small Cell Lung Carcinoma	詳細
CRN-09682	CRN-09682; CRN09682	Phase 2 Clinical	Crinetics Pharmaceuticals Inc	Carcinoma, Neuroendocrine; Neuroendocrine Tumors	詳細
MB-0151		Phase 2 Clinical	Mainline Biosciences (Shanghai) Co Ltd, Zhongshan Zhuliuyuan Biotechnology Co Ltd	Solid tumours	詳細
177Lu-LNC1010	177Lu-LNC1010	Phase 2 Clinical	Yantai Lannacheng Biotechnology Co Ltd	Neoplasms; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Solid tumours	詳細
[203-Pb] VMT-NET	[203-Pb] VMT-NET	Phase 2 Clinical	Perspective Therapeutics Inc	Carcinoma, Renal Cell; Head and Neck Neoplasms; Neuroendocrine Tumors; Paraganglioma; Pheochromocytoma; Small Cell Lung Carcinoma	詳細
64Cu-SarTate		Phase 2 Clinical	Clarity Pharmaceuticals Ltd, University Of Melbourne	Neuroendocrine Tumors	詳細
Gallium-68 satoreotide	68Ga-DOTA-JR11; 68Ga-SSO-120; 68Ga IPN-1070; 68Ga-OPS-202	Phase 1 Clinical	Ipsen Inc	Breast Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Small Cell Lung Carcinoma	詳細
68Ga-NOTA-3PTATE-RGD	68Ga-NOTA-3P-TATE-RGD; 68Ga-NOTA-3PTATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Carcinoma, Neuroendocrine; Lung Neoplasms; Meningioma; Neuroendocrine Tumors	詳細
[68Ga]Ga-FL-031		Phase 1 Clinical	Full Life Technologies Ltd	Neoplasms	詳細
NTQ-6179	NTQ-6179	Phase 1 Clinical	Nanjing Zhengda Tianqing Pharmaceutical Co Ltd	Acromegaly; Neuroendocrine Tumors	詳細
68Ga-DOTA-LM3	68Ga-DOTA-LM3	Phase 1 Clinical	Peking Union Medical College	Neuroendocrine Tumors	詳細
68Ga-NODAGA-LM3	68Ga-NODAGA-LM3	Phase 1 Clinical	Peking Union Medical College	Neuroendocrine Tumors	詳細
177Lu-DOTA-LM3	177Lu-DOTA-LM3	Phase 1 Clinical	Zentralklinik Bad Berka	Neuroendocrine Tumors	詳細
177Lu-TATE-RGD	177Lu-TATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Neoplasms	詳細
[99mTc]Tc-TECANT1		Phase 1 Clinical	Jagiellonian University Sylff Fellows Association, Ljubljana University Medical Centre, Medical University Of Innsbruck, Narodowe Centrum Badan Jadrowych	Neuroendocrine Tumors	詳細
161Tb-DOTA-LM3	161Tb-DOTA-LM3	Phase 1 Clinical	University Hospital Basel	Gastroenteropancreatic neuroendocrine tumor; Neuroendocrine Tumors	詳細
44Sc-edotreotide	Sc44-DOTATOC; 44Sc-DOTA-[3-Tyr]-octreotide; 44Sc-edotreotide	Clinical	Zentralklinik Bad Berka	Diagnostic agents	詳細
68Ga-FAPI-LM3	68Ga-FAPI-LM3	Clinical	The First Affiliated Hospital Of Xiamen University	Adenomatous Polyposis Coli	詳細
225AcDOTA-LM3	225AcDOTA-LM3	Clinical	CURANOSTICUM Wiesbaden-Frankfurt	Pancreatic neuroendocrine tumors (pNET)	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Pasireotide Pamoate		Approved	Novartis Pharma Ag	Signifor lar	United States	Acromegaly	Recordati Rare Diseases Inc	2014-12-15	Acromegaly; Carcinoid Tumor; Cushing Syndrome; Gigantism; Meningioma; Neuroendocrine Tumors; Pituitary ACTH Hypersecretion	詳細
Lutetium (177Lu) oxodotreotide	Lu-DOTATATE; 177Lu-DOTATATE; [Lu-177]-DOTATATE; AAA-601; F-1515; XTR-008; [177Lu]Lu-DOTA-TATE; Lutetium (177Lu) DOTA-TATE	Approved	Advanced Accelerator Applications Sa	Lutathera	EU	Neuroendocrine Tumors	Advanced Accelerator Applications Sa	2017-09-26	Adenoma, Islet Cell; Breast Neoplasms; Bronchial Neoplasms; Carcinoid Heart Disease; Carcinoma, Neuroendocrine; Gastroenteropancreatic neuroendocrine tumor; Leiomyosarcoma; Liver Neoplasms; Malignant Carcinoid Syndrome; Medullary thyroid cancer (MTC); Meningioma; Metastatic breast cancer; Neuroblastoma; Neuroendocrine Carcinoma of Lung; Neuroendocrine Tumors; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Paraganglioma; Pheochromocytoma; Pituitary Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma	詳細
Paltusotine	CRN-00808	Approved	Crinetics Pharmaceuticals Inc	PALSONIFY	United States	Acromegaly	Crinetics Pharmaceuticals Inc	2025-09-25	Acromegaly; Carcinoid Tumor; Cecal Neoplasms; Diarrhea; Ileal Neoplasms; Intestinal Neoplasms; Liver Neoplasms; Malignant Carcinoid Syndrome; Neuroendocrine Tumors; Pancreatic Neoplasms	詳細
Vapreotide Acetate	RC-160; BMY-41606	Approved	Debiopharm Group	Sanvar, Docrised, Sanvar IR, Sanvar SR					Acromegaly; Crohn Disease; Diarrhea; Esophageal and Gastric Varices; Hemorrhage; Hypertension, Portal; Intraoperative Complications; Neuroendocrine Tumors; Pancreatic Neoplasms; Postoperative Complications	詳細
Pasireotide Diaspartate	SOM-230; SOM-230C; SOM-320	Approved	Novartis Pharma Ag	Signifor, 丝尼芬	EU	Cushing Syndrome	Recordati Rare Diseases Inc	2012-04-24	Acromegaly; ACTH Syndrome, Ectopic; Adenoma, Islet Cell; Alcoholism; Carcinoid Tumor; Carcinoma, Hepatocellular; Cluster Headache; Congenital Hyperinsulinism; Cushing Syndrome; Cysts; Dumping Syndrome; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Hormone-Resistant Prostate Neoplasms; Hyperinsulinism; Hypoglycemia; Insulinoma; Liver Cirrhosis; Medullary thyroid cancer (MTC); Meningioma; Multiple Myeloma; Nelson Syndrome; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; Post-bariatric Hypoglycemia; Prolactinoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency; Small Cell Lung Carcinoma; Thymoma; Thyroid Neoplasms; Uveal melanoma	詳細
Ga-68 Edotreotide	SMT-487; [68Ga]DOTATOC; 68Ga-DOTATOC	Approved	Advanced Accelerator Applications Sa	SomaKit TOC, Gallium Dotatoc Ga 68, TOCscan	EU	Diagnostic agents; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET)	Advanced Accelerator Applications Sa	2016-12-08	Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Diagnostic agents; Medulloblastoma; Meningioma; Multiple Endocrine Neoplasia Type 1; Nasopharyngeal Carcinoma; Neuroblastoma; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Paraganglioma; Pituitary Neoplasms; Solid tumours; Somatostatinoma; von Hippel-Lindau Disease	詳細
Gallium (68Ga) oxodotreotide	68Ga-DOTA-TATE; 68-Ga-DOTA-TATE; AAA-501	Approved	Advanced Accelerator Applications Sa	Netspot	United States	Neuroendocrine Tumors	Aaa Usa Inc	2016-06-01	Carcinoid Tumor; Carcinoma, Neuroendocrine; Neuroendocrine Tumors; Pancreatic Neoplasms; Paraganglioma; Pheochromocytoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Thyroid Neoplasms; von Hippel-Lindau Disease	詳細