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STEAP1

STEAP1 詳細

英語名	Six-transmembrane epithelial antigen of the prostate 1	市販薬剤の数	0
治験薬の数	7	ターゲットの別称	PRSS24，Six-transmembrane epithelial antigen of prostate 1，STEAP，STEAP1，STEAP Family Member 1，Six Transmembrane Epithelial Antigen Of The Prostate 1，STEAP1 Metalloreductase，Six Transmembrane Epithelial Antigen Of The Prostate，Metalloreductase STEAP1，EC 1.16.1.-，EC:1.16.1.-
研究＆開発段階	Phase 3 Clinical

英語名	Six-transmembrane epithelial antigen of the prostate 1
ターゲットの別称	PRSS24，Six-transmembrane epithelial antigen of prostate 1，STEAP，STEAP1，STEAP Family Member 1，Six Transmembrane Epithelial Antigen Of The Prostate 1，STEAP1 Metalloreductase，Six Transmembrane Epithelial Antigen Of The Prostate，Metalloreductase STEAP1，EC 1.16.1.-，EC:1.16.1.-
市販薬剤の数	0
治験薬の数	7
研究＆開発段階	Phase 3 Clinical

STEAP1 製品リスト

属性
Cell (2)Protein (6)
製品ライブラリ
オンライン (8)
種
Human (7)Rat (1)
タグ
- (2)His Tag & Strep Tag (3)Tag Free (1)His Tag & Avi Tag & Flag Tag (1)His Tag & Flag Tag (1)
マーカー
- (2)Unconjugated (5)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT CHEK-ATP154	Human	HEK293	HEK293/Human STEAP1 Stable Cell Line
HOT AIDD‑Ready ST1-H5283	Human	HEK293	Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Detergent)
HOT AIDD‑Ready ST1-H82D3	Human	HEK293	Biotinylated Human STEAP1 Full Length Protein, Avitag™,Flag&His Tag (Detergent)
SCCHO-ATP121	Human	CHO	CHO/Human STEAP1 Stable Cell Line
AIDD‑Ready ST1-H5286	Human	HEK293	Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Nanodisc)
AIDD‑Ready ST1-H5287	Human	HEK293	High-Purity Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Detergent)
ST1-H52P3	Human	HEK293	Human STEAP1 Full Length Protein (VLP)
ST1-R52D3	Rat	HEK293	Rat STEAP1 Protein, Flag,His Tag (Detergent)

総数量8

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STEAP1バックグランド

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III). Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.

STEAP1分子の別称

STEAP1, PRSS24, STEAP

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Xaluritamig	AMG-509	Phase 3 Clinical	Amgen Inc, Xencor Inc	Castration-Sensitive Prostate Neoplasms; Hormone-Sensitive Prostate Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Ewing	詳細
89Zr-DFO-MSTP2109A		Phase 2 Clinical	Genentech Inc, Memorial Sloan Kettering Cancer Center	Prostatic Neoplasms	詳細
STEAP1 CART Cell Therapy(PromiCell)		Phase 2 Clinical	Fred Hutchinson Cancer Research Center, PromiCell Therapeutics Inc	Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	詳細
PRO CAR-201A	PRO CAR-201A	Phase 1 Clinical	Fred Hutchinson Cancer Research Center	Prostatic Neoplasms, Castration-Resistant	詳細
ABBV-969	ABBV-969; ABBV969	Phase 1 Clinical	Abbvie Inc	Prostatic Neoplasms, Castration-Resistant	詳細
ADRX-0405	ADRX-0405	Phase 1 Clinical	Adcentrx Therapeutics Inc	Neoplasms; Solid tumours	詳細
DXC-008	DAC-008; DXC-008	Phase 1 Clinical	Hangzhou Dac Biotech Company Ltd	Prostatic Neoplasms; Sarcoma, Ewing; Solid tumours	詳細