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Tau

Tau 詳細

英語名	Microtubule-associated protein tau	市販薬剤の数	1
治験薬の数	45	ターゲットの別称	MAPT，MTBT1，Paired helical filament-tau，MAPTL，Microtubule Associated Protein Tau，G Protein Beta1/Gamma2 Subunit-Interacting Factor 1，Protein Phosphatase 1， Regulatory Subunit 103，Neurofibrillary Tangle Protein，PHF-Tau，TAU，Microtubule-Associated Protein Tau， Isoform 4，Microtubule-Associated Protein Tau，PPP1R103，FTDP-17，MTBT2，DDPAC，MSTD，PPND，tau Proteins，MGC138549，FLJ31424
研究＆開発段階	Approved

英語名	Microtubule-associated protein tau
ターゲットの別称	MAPT，MTBT1，Paired helical filament-tau，MAPTL，Microtubule Associated Protein Tau，G Protein Beta1/Gamma2 Subunit-Interacting Factor 1，Protein Phosphatase 1， Regulatory Subunit 103，Neurofibrillary Tangle Protein，PHF-Tau，TAU，Microtubule-Associated Protein Tau， Isoform 4，Microtubule-Associated Protein Tau，PPP1R103，FTDP-17，MTBT2，DDPAC，MSTD，PPND，tau Proteins，MGC138549，FLJ31424
市販薬剤の数	1
治験薬の数	45
研究＆開発段階	Approved

Tau 製品リスト

属性
Protein (20)Cell (1)Antibody (2)
製品ライブラリ
オンライン (23)
種
Human (20)Cynomolgus (1)Mouse (2)
タグ
His Tag (8)Tag Free (11)GFP Tag (1)- (2)His Tag & Avi Tag (1)
マーカー
Unconjugated (21)- (1)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT CHEK-ATP087	Human	HEK293	HEK293/Human Tau-K18 (GFP) Stable Cell Line
HOT TAU-H5113	Human	E. coli	Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free
HOT TAU-H5115	Human	E. coli	Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free
HOT TAU-H5117	Human	E. coli	Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (MALS verified)
HOT TAU-H51H3	Human	E. coli	Human Tau-441 / 2N4R Protein, His Tag, low endotoxin
TAU-H5112	Human	E. coli	Human Tau-381 / 1N3R Protein, Tag Free, low endotoxin (MALS verified)
TAU-H5114	Human	E. coli	Human Tau Protein, Tag Free, low endotoxin (MALS verified)
TAU-H5116	Human	E. coli	Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free
TAU-H5118	Human	E. coli	Human Tau-441 (K18, P301L) Protein, Tag Free, low endotoxin (MALS verified)
TAU-H5119	Human	E. coli	Human Tau-412 / 1N4R Protein, Tag Free, low Endotoxin (MALS verified)

総数量23

Tauバックグランド

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Tau分子の別称

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease	詳細
Florzolotau	F0-PBB3; PM-PBB3; [18F]APN-1607; [18F]MNI-958; APN-0000455; [18F]PM-PBB3; APN-1607; 18F-PM-PBB3; 18F-APN-1607	Phase 3 Clinical	Aprinoia Therapeutics Ltd	Alzheimer Disease; Cognition Disorders; Cognitive Dysfunction; Diagnostic agents; Nerve Degeneration; Supranuclear Palsy, Progressive	詳細
Etalanetug	E-2814	Phase 3 Clinical	Eisai Co Ltd	Alzheimer Disease; Dementia	詳細
Izaflortaucipir F-18	PI-2620; 18F-PI-2620; [18F]PI-2620	Phase 3 Clinical	Ac Immune Sa, Piramal	Alzheimer Disease; Brain Injuries, Traumatic; Cognitive Dysfunction; Frontotemporal Lobar Degeneration; Opioid-Related Disorders; Parkinson Disease; Supranuclear Palsy, Progressive	詳細
[F-18]Flornaptitril	[F-18]FDDNP; F-18-FNT-PET	Phase 3 Clinical	University Of California At Los Angeles	Alzheimer Disease; Chronic Traumatic Encephalopathy	詳細
XTR-006	XTR-006	Phase 3 Clinical	Beijing Xiantong International Technology Co Ltd	Alzheimer Disease; Tauopathies	詳細
Zagotenemab	LY-3303560	Phase 2 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
Posdinemab	JNJ-3657; JNJ-63733657	Phase 2 Clinical	Johnson & Johnson Innovative Medicine	Alzheimer Disease; Cognitive Dysfunction; Dementia	詳細
[18F]GTP-1	[18F]GTP-1	Phase 2 Clinical	Genentech Inc	Alzheimer Disease	詳細
[18F]THK-5105	[18F]THK-5105	Phase 2 Clinical	Tohoku University	Alzheimer Disease	詳細
ISIS-814907	BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX	Phase 2 Clinical	Biogen Inc, Ionis Pharmaceuticals Inc	Alzheimer Disease; Cognitive Dysfunction	詳細
Tilavonemab	C2N-8E12; ABBV-8E12	Phase 2 Clinical	C2n Diagnostics Llc	Alzheimer Disease; Supranuclear Palsy, Progressive	詳細
Alzheimer's disease vaccine (Axon Neuroscience)	AADvac-1	Phase 2 Clinical	Axon Biochemicals	Alzheimer Disease; Primary Progressive Nonfluent Aphasia; Supranuclear Palsy, Progressive	詳細
Semorinemab	MTAU-9937A; MTAU9937A; RG-6100; RO7105705; RO-7105705	Phase 2 Clinical	Ac Immune Sa	Alzheimer Disease	詳細
APN-1701	[18F]AM-PBB3; 18F-AM-PBB3; APN-1701	Phase 2 Clinical	Aprinoia Therapeutics Ltd, National Institute Of Radiological Sciences	Alzheimer Disease; Nerve Degeneration	詳細
VY-TAU-01	VY-TAU01; VY-TAU-01; VY-7523	Phase 2 Clinical	Voyager Therapeutics Inc	Alzheimer Disease	詳細
Anti-tau antibody (Prothena)	BMS-986446; PRX-005	Phase 2 Clinical	Prothena	Alzheimer Disease; Frontotemporal Dementia	詳細
MK-2214	MK-2214	Phase 2 Clinical	Merck Sharp & Dohme LLC	Alzheimer Disease	詳細
BEY-2153	BEY-2153	Phase 2 Clinical	Beyondbio Inc	Alzheimer Disease	詳細
Bepranemab	UCB-0107; RG6416	Phase 2 Clinical	Ucb	Alzheimer Disease; Supranuclear Palsy, Progressive	詳細
[18F]THK-5117	[18F]THK-5117	Phase 2 Clinical	Tohoku University	Alzheimer Disease	詳細
PNT-001	PNT-001	Phase 1 Clinical	Beth Israel Deaconess Medical Center	Alzheimer Disease; Brain Injuries, Traumatic	詳細
ReS19-T	ReS19-T	Phase 1 Clinical	Remynd	Alzheimer Disease	詳細
Mecripyrine Hydrochloride	SCR-1693; Y-1A; Y-1	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, NeuroDawn Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd	Alzheimer Disease; Brain Neoplasms	詳細
Lu-AF87908	Lu-AF87908; Lu-AF-87908	Phase 1 Clinical	H. Lundbeck A/S	Alzheimer Disease	詳細
RDC-5	RDC-5	Phase 1 Clinical	Chronos Therapeutics Ltd	Amyotrophic Lateral Sclerosis	詳細
MC-1 (Lilly)	MC-1 (Lilly)	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
OLX-07010	OLX07010	Phase 1 Clinical	Oligomerix Inc	Alzheimer Disease; Dementia; Neurodegenerative Diseases; Supranuclear Palsy, Progressive	詳細
Protollin		Phase 1 Clinical	The Brigham and Women's Hospital	Alzheimer Disease	詳細
NB-02	NB-02; DA-9803	Phase 1 Clinical	Dong-A ST Co Ltd	Alzheimer Disease; Lymphoma, Non-Hodgkin	詳細
MAPT siRNA therapeutic (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neurodegenerative Diseases	詳細
18F-JSS20-183A	18F-JSS20-183A	Phase 1 Clinical	University Of Pennsylvania	Tauopathies	詳細
ATC-102	ATC-102; ATC102	Phase 1 Clinical	Autotac Bio Inc	Alzheimer Disease	詳細
AB-19 (AUTOTAC Bio)	AB-19 (AUTOTAC Bio)	Phase 1 Clinical	Autotac Bio Inc	Supranuclear Palsy, Progressive	詳細
AB-12 po (AUTOTAC Bio)	AB-12 po	Phase 1 Clinical	Autotac Bio Inc	Alzheimer Disease	詳細
DNL-628	OTV:MAPT; DNL-628	Phase 1 Clinical	Denali Therapeutics Inc	Alzheimer Disease	詳細
[89Zr]Zr-DFO-BIIB080	[89Zr]Zr-DFO; [89Zr]Zr-DFO-ISIS-814907	Phase 1 Clinical	Biogen Inc		詳細
DA-7503	DA-7503	Phase 1 Clinical	Dong-A ST Co Ltd		詳細
LY-3954068	LY3954068; LY-3954068	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
AS-603	S-603; AS-603; AS-S603	Phase 1 Clinical	Amyloid Solution Inc	Alzheimer Disease	詳細
ADEL-Y01	ADEL-Y01	Phase 1 Clinical	ADEL Inc, Oscotec Inc	Alzheimer Disease; Tauopathies	詳細
APNmAb-005	APNmAb-005	Phase 1 Clinical	Aprinoia Therapeutics Ltd	Alzheimer Disease; Nerve Degeneration; Tauopathies	詳細
AV-1959R/AV-1980R	1959R + 1980R; AV 1959R + AV 1980R	Phase 1 Clinical	Nuravax	Alzheimer Disease	詳細
NIO-752	NIO-752	Phase 1 Clinical	Novartis Pharma Ag	Alzheimer Disease; Cognitive Dysfunction; Neurodegenerative Diseases; Supranuclear Palsy, Progressive	詳細
11C-PBB3	11C-PBB3	Clinical	National Institute Of Radiological Sciences	Alzheimer Disease	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Flortaucipir F18	18F-AV-1451; T807; F-18-AV-1451; [18F]-T-807; [3H]AV 1451; [F-18]T807; [F18]AV1451; LY3191748	Approved	Siemens Medical Solution	Tauvid	United States	Alzheimer Disease	Avid Radiopharmaceuticals Inc	2020-05-28	Alzheimer Disease; Aphasia, Primary Progressive; Brain Concussion; Brain Injuries; Brain Injuries, Traumatic; Chronic Traumatic Encephalopathy; Cognition Disorders; Cognitive Dysfunction; Corticobasal degeneration; Dementia; Depression; Diagnostic agents; Frontotemporal Dementia; Neurodegenerative Diseases; Parkinson Disease; Pick Disease of the Brain; Supranuclear Palsy, Progressive; Tauopathies	詳細

レビュー

P***g2021-08-24
5評価
Human Tau-441 / 2N4R Protein, His Tag, low endotoxin
I have purchased multiple antigens from ACRO for discovery projects and I have found that the quality of antigens purchased from Acro is great!! Acro has become by go to vendor when I am looking for quality antigens. In addition, Acro also provides an impressive range of formats for each antigens, including different tags. Not to mention, their customer service team is fantastic. Overall, a great company to work with.