Tau Proteins, Antibodies & Cell Lines

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Tau 詳細

Molecule Name

Microtubule-associated protein tau

分子の別称

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

Drug Development Progress

治験薬の数45

市販薬剤の数1

研究＆開発段階Approved

ターゲットの別称

MAPT，MTBT1，Paired helical filament-tau，MAPTL，Microtubule Associated Protein Tau，G Protein Beta1/Gamma2 Subunit-Interacting Factor 1，Protein Phosphatase 1， Regulatory Subunit 103，Neurofibrillary Tangle Protein，PHF-Tau，TAU，Microtubule-Associated Protein Tau， Isoform 4，Microtubule-Associated Protein Tau，PPP1R103，FTDP-17，MTBT2，DDPAC，MSTD，PPND，tau Proteins，MGC138549，FLJ31424

バックグランド

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Tau 製品リスト

Molecule	Cat. No.	Product Name	種	Host	Purity	Activity	Size&Price
Tau	HOT TAU-H5115	Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free	Human	E. coli	SDS-PAGE	CELL BASEThT	$400.00 100ug
Tau	HOT TAU-H5113	Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free	Human	E. coli	SDS-PAGE	CELL BASE	$375.00 100ug
Tau	HOT TAU-H51H3	Human Tau-441 / 2N4R Protein, His Tag, low endotoxin	Human	E. coli	SDS-PAGE	ELISA	$305.00 100ug
Tau	HOT TAU-H5117	Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (Mass Spec & MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISAThT	$305.00 100ug
Tau	TAU-C5113	Cynomolgus Tau Protein, Tag Free, low endotoxin	Cynomolgus	Yeast		ELISA	$360.00 100ug
Tau	TAU-H5112	Human Tau-381 / 1N3R Protein, Tag Free, low endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISA	$280.00 100ug
Tau	TAU-H5114	Human Tau Protein, Tag Free, low endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE		$290.00 100ug
Tau	TAU-H5116	Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free	Human	E. coli	SDS-PAGE		$375.00 100ug
Tau	TAU-H5118	Human Tau-441 (K18, P301L) Protein, Tag Free, low endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE		$290.00 100ug
Tau	TAU-H5119	Human Tau-412 / 1N4R Protein, Tag Free, low Endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISA	$295.00 100ug

Tau >

Hot

Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free

Cat. No. TAU-H5115

種

Human

Host

E. coli

Purity

SDS-PAGE

Activity

CELL BASEThT

$400.00

Tau >

Hot

Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free

Cat. No. TAU-H5113

種

Human

Host

E. coli

Purity

SDS-PAGE

Activity

CELL BASE

$375.00

Tau >

Hot

Human Tau-441 / 2N4R Protein, His Tag, low endotoxin

Cat. No. TAU-H51H3

種

Human

Host

E. coli

Purity

SDS-PAGE

Activity

ELISA

$305.00

Tau >

Hot

Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (Mass Spec & MALS verified)

Cat. No. TAU-H5117

種

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISAThT

$305.00

Tau >

Cynomolgus Tau Protein, Tag Free, low endotoxin

Cat. No. TAU-C5113

種

Cynomolgus

Host

Yeast

Activity

ELISA

$360.00

Tau >

Human Tau-381 / 1N3R Protein, Tag Free, low endotoxin (MALS verified)

Cat. No. TAU-H5112

種

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$280.00

Tau >

Human Tau Protein, Tag Free, low endotoxin (MALS verified)

Cat. No. TAU-H5114

種

Human

Host

E. coli

Purity

MALSSDS-PAGE

$290.00

Tau >

Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free

Cat. No. TAU-H5116

種

Human

Host

E. coli

Purity

SDS-PAGE

$375.00

Tau >

Human Tau-441 (K18, P301L) Protein, Tag Free, low endotoxin (MALS verified)

Cat. No. TAU-H5118

種

Human

Host

E. coli

Purity

MALSSDS-PAGE

$290.00

Tau >

Human Tau-412 / 1N4R Protein, Tag Free, low Endotoxin (MALS verified)

Cat. No. TAU-H5119

種

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$295.00

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FAQ

How does the P301L mutation affect Tau aggregation and disease modeling?

P301L is a pathogenic Tau mutation associated with familial frontotemporal dementia and other tauopathies. The mutation can increase the aggregation propensity of Tau and is widely used to study Tau misfolding and pathological aggregation. Recombinant P301L Tau proteins and P301L-containing PFFs can support cell-based, organoid and animal models for investigating Tau aggregation, seeding mechanisms, and potential therapeutic interventions.

How can I study different forms of Tau in neurodegenerative disease research?

Different forms of Tau can be investigated to model distinct aspects of Tau pathology. Recombinant Tau proteins with specific isoforms, disease-associated mutations, or phosphorylation states can be used to study Tau structure, aggregation, and molecular interactions. Phosphorylated Tau antibodies help detect and characterize disease-associated Tau species, while Tau stable cell lines provide cell-based models for studying intracellular Tau aggregation and evaluating potential therapeutic effects.

How are Tau aggregation and seeding studied using Tau PFFs?

Tau pre-formed fibrils (PFFs) are widely used as experimental seeds to model pathological Tau aggregation. When introduced into cell, organoid, or animal models, Tau PFFs can promote the recruitment and aggregation of endogenous Tau, enabling researchers to study Tau seeding, intracellular aggregation, and propagation. PFF-based models can also be used to evaluate therapeutic strategies targeting Tau pathology.

What is a tauopathy, and which neurodegenerative diseases are associated with Tau pathology?

Tauopathies are a group of neurodegenerative disorders characterized by abnormal accumulation and aggregation of Tau in the brain. Alzheimer’s disease is the most common tauopathy, while other tauopathies include progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal lobar degeneration (FTLD) with Tau pathology. Different tauopathies are associated with distinct Tau isoforms, post-translational modifications, and aggregation patterns.

What is Tau protein, and what is its role in neurons?

Tau is a microtubule-associated protein predominantly expressed in neurons, where it helps regulate microtubule stability and organization, particularly in axons. Tau function is regulated by post-translational modifications, including phosphorylation. Abnormal Tau modification, misfolding, and aggregation can disrupt neuronal function and contribute to neurodegenerative disease.

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Resources

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease	詳細
Florzolotau	F0-PBB3; PM-PBB3; [18F]APN-1607; [18F]MNI-958; APN-0000455; [18F]PM-PBB3; APN-1607; 18F-PM-PBB3; 18F-APN-1607	Phase 3 Clinical	Aprinoia Therapeutics Ltd	Alzheimer Disease; Cognition Disorders; Cognitive Dysfunction; Diagnostic agents; Nerve Degeneration; Supranuclear Palsy, Progressive	詳細
Etalanetug	E-2814	Phase 3 Clinical	Eisai Co Ltd	Alzheimer Disease; Dementia	詳細
Izaflortaucipir F-18	PI-2620; 18F-PI-2620; [18F]PI-2620	Phase 3 Clinical	Ac Immune Sa, Piramal	Alzheimer Disease; Brain Injuries, Traumatic; Cognitive Dysfunction; Frontotemporal Lobar Degeneration; Opioid-Related Disorders; Parkinson Disease; Supranuclear Palsy, Progressive	詳細
[F-18]Flornaptitril	[F-18]FDDNP; F-18-FNT-PET	Phase 3 Clinical	University Of California At Los Angeles	Alzheimer Disease; Chronic Traumatic Encephalopathy	詳細
XTR-006	XTR-006	Phase 3 Clinical	Beijing Xiantong International Technology Co Ltd	Alzheimer Disease; Tauopathies	詳細
Zagotenemab	LY-3303560	Phase 2 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
Posdinemab	JNJ-3657; JNJ-63733657	Phase 2 Clinical	Johnson & Johnson Innovative Medicine	Alzheimer Disease; Cognitive Dysfunction; Dementia	詳細
[18F]GTP-1	[18F]GTP-1	Phase 2 Clinical	Genentech Inc	Alzheimer Disease	詳細
[18F]THK-5105	[18F]THK-5105	Phase 2 Clinical	Tohoku University	Alzheimer Disease	詳細
ISIS-814907	BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX	Phase 2 Clinical	Biogen Inc, Ionis Pharmaceuticals Inc	Alzheimer Disease; Cognitive Dysfunction	詳細
Tilavonemab	C2N-8E12; ABBV-8E12	Phase 2 Clinical	C2n Diagnostics Llc	Alzheimer Disease; Supranuclear Palsy, Progressive	詳細
Alzheimer's disease vaccine (Axon Neuroscience)	AADvac-1	Phase 2 Clinical	Axon Biochemicals	Alzheimer Disease; Primary Progressive Nonfluent Aphasia; Supranuclear Palsy, Progressive	詳細
Semorinemab	MTAU-9937A; MTAU9937A; RG-6100; RO7105705; RO-7105705	Phase 2 Clinical	Ac Immune Sa	Alzheimer Disease	詳細
APN-1701	[18F]AM-PBB3; 18F-AM-PBB3; APN-1701	Phase 2 Clinical	Aprinoia Therapeutics Ltd, National Institute Of Radiological Sciences	Alzheimer Disease; Nerve Degeneration	詳細
VY-TAU-01	VY-TAU01; VY-TAU-01; VY-7523	Phase 2 Clinical	Voyager Therapeutics Inc	Alzheimer Disease	詳細
Anti-tau antibody (Prothena)	BMS-986446; PRX-005	Phase 2 Clinical	Prothena	Alzheimer Disease; Frontotemporal Dementia	詳細
MK-2214	MK-2214	Phase 2 Clinical	Merck Sharp & Dohme LLC	Alzheimer Disease	詳細
BEY-2153	BEY-2153	Phase 2 Clinical	Beyondbio Inc	Alzheimer Disease	詳細
Bepranemab	UCB-0107; RG6416	Phase 2 Clinical	Ucb	Alzheimer Disease; Supranuclear Palsy, Progressive	詳細
[18F]THK-5117	[18F]THK-5117	Phase 2 Clinical	Tohoku University	Alzheimer Disease	詳細
PNT-001	PNT-001	Phase 1 Clinical	Beth Israel Deaconess Medical Center	Alzheimer Disease; Brain Injuries, Traumatic	詳細
ReS19-T	ReS19-T	Phase 1 Clinical	Remynd	Alzheimer Disease	詳細
Mecripyrine Hydrochloride	SCR-1693; Y-1A; Y-1	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, NeuroDawn Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd	Alzheimer Disease; Brain Neoplasms	詳細
Lu-AF87908	Lu-AF87908; Lu-AF-87908	Phase 1 Clinical	H. Lundbeck A/S	Alzheimer Disease	詳細
RDC-5	RDC-5	Phase 1 Clinical	Chronos Therapeutics Ltd	Amyotrophic Lateral Sclerosis	詳細
MC-1 (Lilly)	MC-1 (Lilly)	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
OLX-07010	OLX07010	Phase 1 Clinical	Oligomerix Inc	Alzheimer Disease; Dementia; Neurodegenerative Diseases; Supranuclear Palsy, Progressive	詳細
Protollin		Phase 1 Clinical	The Brigham and Women's Hospital	Alzheimer Disease	詳細
NB-02	NB-02; DA-9803	Phase 1 Clinical	Dong-A ST Co Ltd	Alzheimer Disease; Lymphoma, Non-Hodgkin	詳細
MAPT siRNA therapeutic (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neurodegenerative Diseases	詳細
18F-JSS20-183A	18F-JSS20-183A	Phase 1 Clinical	University Of Pennsylvania	Tauopathies	詳細
ATC-102	ATC-102; ATC102	Phase 1 Clinical	Autotac Bio Inc	Alzheimer Disease	詳細
AB-19 (AUTOTAC Bio)	AB-19 (AUTOTAC Bio)	Phase 1 Clinical	Autotac Bio Inc	Supranuclear Palsy, Progressive	詳細
AB-12 po (AUTOTAC Bio)	AB-12 po	Phase 1 Clinical	Autotac Bio Inc	Alzheimer Disease	詳細
DNL-628	OTV:MAPT; DNL-628	Phase 1 Clinical	Denali Therapeutics Inc	Alzheimer Disease	詳細
[89Zr]Zr-DFO-BIIB080	[89Zr]Zr-DFO; [89Zr]Zr-DFO-ISIS-814907	Phase 1 Clinical	Biogen Inc		詳細
DA-7503	DA-7503	Phase 1 Clinical	Dong-A ST Co Ltd		詳細
LY-3954068	LY3954068; LY-3954068	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	詳細
AS-603	S-603; AS-603; AS-S603	Phase 1 Clinical	Amyloid Solution Inc	Alzheimer Disease	詳細
ADEL-Y01	ADEL-Y01	Phase 1 Clinical	ADEL Inc, Oscotec Inc	Alzheimer Disease; Tauopathies	詳細
APNmAb-005	APNmAb-005	Phase 1 Clinical	Aprinoia Therapeutics Ltd	Alzheimer Disease; Nerve Degeneration; Tauopathies	詳細
AV-1959R/AV-1980R	1959R + 1980R; AV 1959R + AV 1980R	Phase 1 Clinical	Nuravax	Alzheimer Disease	詳細
NIO-752	NIO-752	Phase 1 Clinical	Novartis Pharma Ag	Alzheimer Disease; Cognitive Dysfunction; Neurodegenerative Diseases; Supranuclear Palsy, Progressive	詳細
11C-PBB3	11C-PBB3	Clinical	National Institute Of Radiological Sciences	Alzheimer Disease	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Flortaucipir F18	18F-AV-1451; T807; F-18-AV-1451; [18F]-T-807; [3H]AV 1451; [F-18]T807; [F18]AV1451; LY3191748	Approved	Siemens Medical Solution	Tauvid	United States	Alzheimer Disease	Avid Radiopharmaceuticals Inc	2020-05-28	Alzheimer Disease; Aphasia, Primary Progressive; Brain Concussion; Brain Injuries; Brain Injuries, Traumatic; Chronic Traumatic Encephalopathy; Cognition Disorders; Cognitive Dysfunction; Corticobasal degeneration; Dementia; Depression; Diagnostic agents; Frontotemporal Dementia; Neurodegenerative Diseases; Parkinson Disease; Pick Disease of the Brain; Supranuclear Palsy, Progressive; Tauopathies	詳細

Customer Reviews

P***g2021-08-24
Human Tau-441 / 2N4R Protein, His Tag, low endotoxin
I have purchased multiple antigens from ACRO for discovery projects and I have found that the quality of antigens purchased from Acro is great!! Acro has become by go to vendor when I am looking for quality antigens. In addition, Acro also provides an impressive range of formats for each antigens, including different tags. Not to mention, their customer service team is fantastic. Overall, a great company to work with.