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TDP-43

TDP-43 Overview

English Name	TAR DNA binding protein 43	Approved Drugs	0
Drugs in Clinical Trials	6	Target Synonym	TAR DNA-binding protein 43，TARDBP，TAR DNA Binding Protein，TDP43，TAR DNA-Binding Protein-43，ALS10
Highest Development Stage	Phase 3 Clinical

English Name	TAR DNA binding protein 43
Target Synonym	TAR DNA-binding protein 43，TARDBP，TAR DNA Binding Protein，TDP43，TAR DNA-Binding Protein-43，ALS10
Approved Drugs	0
Drugs in Clinical Trials	6
Highest Development Stage	Phase 3 Clinical

TDP-43 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
TD3-H5145	Human	E. coli	Human TDP-43 Protein, His Tag

Total: 1

TDP-43 Background

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

TDP-43 Synonyms

TAR DNA-binding protein 43

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Monepantel	PPL-1; NUZ-001	Phase 3 Clinical	Pitney Pharmaceuticals Pty Ltd	Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Neoplasms	Details
nL-TARD-001	nL-TARD-001	Phase 2 Clinical	N-Lorem Foundation	Amyotrophic Lateral Sclerosis	Details
AMDX-2011P	AMDX2011P; AMDX-2011P	Phase 2 Clinical	Amydis Inc	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cerebral Amyloid Angiopathy; Glaucoma, Open-Angle; Parkinson Disease	Details
VTx-002 (VectorY)	VTx-002	Phase 2 Clinical	VectorY BV	Amyotrophic Lateral Sclerosis	Details
CTx-1000	CTx1000; CTx-1000	Phase 1 Clinical	Celosia Therapeutics Pty Ltd	Amyotrophic Lateral Sclerosis	Details
AB-14	AB-14	Phase 1 Clinical	Autotac Bio Inc	Amyotrophic Lateral Sclerosis	Details

Product Reviews

n***l2026-04-14
0People Like
Human TDP-43 Protein, His Tag
We ordered Human TDP-43 Protein, His Tag and was very happy with the fast shipping to get our project going. Customer service was very helpful on the phone before I placed my order online.