TGF-beta RII 詳細
Molecule Name
Transforming growth factor beta receptor 2
分子の別称
TGFBR2,TGFR2,TbetaR-II,TGFβR2
Drug Development Progress
治験薬の数8
市販薬剤の数0
研究＆開発段階Phase 3 Clinical
ターゲットの別称
NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
バックグランド
TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
TGF-beta RII 製品リスト
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A***n2022-07-30I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.