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TGF-beta RII

TGF-beta RII 詳細

英語名	Transforming growth factor beta receptor 2	市販薬剤の数	0
治験薬の数	8	ターゲットの別称	NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
研究＆開発段階	Phase 3 Clinical

英語名	Transforming growth factor beta receptor 2
ターゲットの別称	NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
市販薬剤の数	0
治験薬の数	8
研究＆開発段階	Phase 3 Clinical

TGF-beta RII 製品リスト

属性
Protein (6)
製品ライブラリ
オンライン (6)
種
Human (5)Mouse (1)
タグ
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)His Tag (1)Llama IgG Fc Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (3)

製品番号	種	発現システム	製品説明
HOT TG2-H52H5	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
HOT TG2-H82E4	Human	HEK293	Biotinylated Human TGF-beta RII / TGFBR2 Protein, His,Avitag™ (HPLC verified)
HOT TG2-M82H5	Mouse	HEK293	Biotinylated Mouse TGF-beta RII / TGFBR2 Protein, His,Avitag™ (MALS verified)
TG2-H5252	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, Fc Tag (MALS verified)
TG2-H5253	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, Llama IgG2b Fc Tag, low Endotoxin (MALS verified)
TG2-H82F6	Human	HEK293	Biotinylated Human TGF-beta RII / TGFBR2 Protein, Fc,Avitag™ (MALS verified)

総数量6

TGF-beta RIIバックグランド

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII分子の別称

TGFBR2,TGFR2,TbetaR-II,TGFβR2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
INCA-33890	INCA33890; INCA-33890	Phase 3 Clinical	Incyte Corp	Colorectal Neoplasms; Ovarian Neoplasms; Solid tumours	詳細
HCW-9218	HCW-9218	Phase 2 Clinical	HCW Biologics Inc	Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Fibrosis; Solid tumours	詳細
TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center)		Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis	詳細
TGFBR2 KO CAR27/IL-15 NK cells therapy (The University Of Texas MD Anderson Cancer Center)		Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphatic Diseases; Pancreatic Neoplasms	詳細
TGFBR-2 KO CD70 CAR NK cell therapy (The University Of Texas MD Anderson Cancer Center)		Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Adenocarcinoma, Clear Cell	詳細
Autologous TGF-betaR2KO/IL13R-alpha2-CAR T cells Therapy(City of Hope Medical Center)		Phase 1 Clinical	City Of Hope National Medical Center	Astrocytoma; Glioblastoma	詳細
RG-6315	RG-6315	Phase 1 Clinical	Genentech Inc	Scleroderma, Systemic	詳細
TASO-001	TASO-001; ATB-301	Phase 1 Clinical	Autotelicbio Co Ltd	Solid tumours	詳細

レビュー

A***n2022-07-30
0評価
Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.