Thrombopoietin R 詳細
Molecule Name
Thrombopoietin receptor
分子の別称
MPL,C-MPL,CD110,MPLV,THCYT2,TPOR
Drug Development Progress
治験薬の数11
市販薬剤の数8
研究＆開発段階Approved
ターゲットの別称
CD110 Antigen，THCYT2，C-MPL，CD110，MPLV，Receptors， Thrombopoietin，MPL，TPOR，Myeloproliferative leukemia protein，Myeloproliferative Leukemia Virus Oncogene，Proto-Oncogene C-Mpl，TPO-R，MPL Proto-Oncogene， Thrombopoietin Receptor，Thrombopoietin Receptor，THPOR
バックグランド
Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.
Thrombopoietin R 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Romiplostim biosimilar (Enzene Biosciences) | 267639-76-9 | Phase 3 Clinical | Enzene Biosciences Ltd | Purpura, Thrombocytopenic, Idiopathic | 詳細 |
| Romiplostim biosimilar (Intas Pharmaceuticals) | Phase 3 Clinical | Intas Biopharmaceuticals | Purpura, Thrombocytopenic, Idiopathic | 詳細 | |
| Romiplostim biosimilar(Generium) | GNR-069 | Phase 3 Clinical | Cjsc Generium | Purpura, Thrombocytopenic, Idiopathic | 詳細 |
| PN-20 | PN20; PN-20; PJ004; PJ-004 | Phase 2 Clinical | Chongqing Peg-Bio Biopharm Co Ltd | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Recombinant human thrombopoietin（Peking University People's Hospital） | Phase 2 Clinical | Peking University People'S Hospital | Parturition; Purpura, Thrombocytopenic, Idiopathic | 詳細 | |
| Recombinant human thrombopoietin mimetics (Shandong Quangang) | Phase 2 Clinical | Shandong Quangang Pharmaceutical Co Ltd | Purpura, Thrombocytopenic, Idiopathic | 詳細 | |
| PEGylated thrombopoietin (Chongqing Paijin Bio) | Phase 2 Clinical | Chongqing Peg-Bio Biopharm Co Ltd | Hematologic Diseases; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 | |
| Romiplostim biosimilar(Geropharma) | GP-40141 | Phase 1 Clinical | Geropharm | Purpura, Thrombocytopenic, Idiopathic | 詳細 |
| SCB-219 | SCB-219-M; SCB-219; SCB-219M | Phase 1 Clinical | Clover Biopharmaceuticals Ltd | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical) | Phase 1 Clinical | Beijing Tide Pharmaceutical Co Ltd | Purpura, Thrombocytopenic, Idiopathic | 詳細 | |
| Thrombopoietin agonist (Scripps Research) | 3D9 | Clinical | The Scripps Research Institute Inc | Thrombocytopenia | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Recombinant human thrombopoietin biosimilar (Biolotus) | Approved | Biolotus | Zypotin-TPO | Brazil | Thrombocytopenia | Biolotus | 2015-01-01 | Thrombocytopenia | 詳細 | |
| Romiplostim | AMP-2; AMG-531 | Approved | Amgen Inc | Romiplate, Nplate | United States | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Amgen Inc | 2008-08-22 | Acute Radiation Syndrome; Anemia, Aplastic; Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Ovarian Neoplasms; Pancytopenia; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Sarcoma, Ewing; Solid tumours; Thrombocytopenia | 詳細 |
| Lusutrombopag | S-888711 | Approved | Shionogi & Co Ltd | Mulpleta | Japan | Thrombocytopenia | Shionogi & Co Ltd | 2015-09-28 | Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Herombopag Olamine | SHR-8735; SHR 8735 olamine | Approved | Jiangsu Hengrui Medicine Co Ltd | Hengqu, 恒曲 | Mainland China | Anemia, Aplastic; Thrombocytopenia | Jiangsu Hengrui Medicine Co Ltd | 2021-06-16 | Anemia, Aplastic; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Liver Diseases; Lung Neoplasms; Nasopharyngeal Carcinoma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Romiplostim biosimilar (Qilu Pharmaceutical) | QL-0911 | Approved | Qilu Pharmaceutical Co Ltd | 瑞立升 | Mainland China | Thrombocytopenia | Qilu Pharmaceutical Co Ltd | 2024-04-02 | Anemia, Aplastic; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Eltrombopag Diolamine | SB-497115-GR; ETB-115; SB-497115 | Approved | Glaxosmithkline Plc | Promacta/Revolade, 瑞弗兰, レボレード, 特艾升, Promacta, Revolade | United States | Purpura, Thrombocytopenic, Idiopathic | Novartis Pharma Ag | 2008-11-20 | Anemia, Aplastic; Anemia, Diamond-Blackfan; Blood Platelet Disorders; Bone Marrow Failure Disorders; Bone marrow transplant rejection; Catheter-Related Infections; Delayed Graft Function; Fanconi Anemia; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hemorrhage; Hepatitis B; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Eosinophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Connective and Soft Tissue; Osteosarcoma; Primary Myelofibrosis; Purpura; Purpura, Thrombocytopenic, Id | 詳細 |
| Avatrombopag Maleate | YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 | Approved | Astellas Pharma Inc | 苏可欣, Doptelet, DOPTELET | United States | Thrombocytopenia; Liver Diseases | Akarx Inc | 2018-05-21 | Anemia, Aplastic; Cardiovascular Diseases; Drug-Related Side Effects and Adverse Reactions; Liver Diseases; Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 詳細 |
| Recombinant human thrombopoietin | rhTPO (3SBio); TPO106; TPO-106 | Approved | Shenyang Sunshine Pharmaceutical Co Ltd | 特比奥, Tpiao, 特比澳, Tebiao | Mainland China | Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic | Shenyang Sunshine Pharmaceutical Co Ltd | 2005-03-10 | Breast Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Cirrhosis; Liver Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic-Myeloproliferative Diseases; Neutropenia; Plasmacytoma; Purpura, Thrombocytopenic, Idiopathic; Radiation sickness; Sepsis; Thrombocytopenia | 詳細 |