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TIM-4

TIM-4 詳細

英語名	T-cell immunoglobulin and mucin domain-containing protein 4	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	T-cell immunoglobulin mucin receptor 4 (TIM-4)，T-cell membrane protein 4，TIM4
研究＆開発段階	Phase 1 Clinical

英語名	T-cell immunoglobulin and mucin domain-containing protein 4
ターゲットの別称	T-cell immunoglobulin mucin receptor 4 (TIM-4)，T-cell membrane protein 4，TIM4
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 1 Clinical

TIM-4 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
TI4-H52H3	Human	HEK293	Human TIM-4 / TIMD4 Protein, His Tag

総数量1

TIM-4バックグランド

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. An essential step during clearance of apoptotic cells is the recognition of phosphatidylserine (PS) exposed on apoptotic cells by its receptors on phagocytes. The phosphatidylserine (PS) receptor Tim-4 mediates phagocytosis of apoptotic cells by binding to PS exposed on the surface of these cells, and thus functions as a PS receptor for apoptotic cells. Tim-4 directly binding to PS and functioning as a tethering receptor for phagocytosis of apoptotic cells has been extensively studied over the past decade. However, the molecular mechanisms by which Tim-4 collaborates with other engulfment receptors during efferocytosis remain elusive.

TIM-4分子の別称

TIM4,TIMD4,SMUCKLER

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
LPX-TI641	LPX-TI-641	Phase 1 Clinical	LAPIX Therapeutics Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Demyelinating Diseases; Dermatitis, Atopic; Multiple Sclerosis; Neuromyelitis Optica; Psoriasis	詳細