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TL1A

TL1A 詳細

英語名	Tumor necrosis factor superfamily member 15	市販薬剤の数	0
治験薬の数	18	ターゲットの別称	VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
研究＆開発段階	Phase 3 Clinical

英語名	Tumor necrosis factor superfamily member 15
ターゲットの別称	VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
市販薬剤の数	0
治験薬の数	18
研究＆開発段階	Phase 3 Clinical

TL1A 製品リスト

属性
Protein (13)Cell (5)Kits (2)
製品ライブラリ
オンライン (19)研究中 (1)
種
Human (12)Cynomolgus / Rhesus macaque (2)Mouse (3)Rat (1)Rabbit (1)Cynomolgus (1)
タグ
His Tag (9)His Tag & Avi Tag (2)- (7)Fc Tag (1)Avi Tag & His Tag (1)
マーカー
Unconjugated (10)Biotin-labeled (3)- (7)

製品番号	種	発現システム	製品説明
HOT TLA-H5243	Human	HEK293	Human TL1A / TNFSF15 Protein, His Tag, active trimer, low endotoxin (MALS verified)
HOT TLA-H52Q1	Human	HEK293	Biotinylated Human TL1A / TNFSF15 Protein, His,Avitag™
HOT TLA-M5243	Mouse	HEK293	Mouse TL1A Protein, His Tag, low endotoxin (HPLC-verified)
HOT TLA-C5241	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, His Tag, low endotoxin (MALS verified)
CEA-C090	Human	-	Human TL1A/TNFSF15 ELISA Kit
CHEK-ATP142	Human	HEK293	HEK293/Human TL1A Stable Cell Line
CHEK-ATP198	Human	HEK293	HEK293/Membrane-Bound human TL1A Stable Cell Line
CRAJ-STP232	Human	Raji	Raji/Human TL1A Stable Cell Line
SCRAJ-STT204	Human	Raji	Raji/Membrane-Bound Human TL1A Stable Cell Line
TLA-H5244	Human	HEK293	Human TL1A / TNFSF15 Protein, His Tag, low endotoxin (MALS verified)

総数量20

TL1Aバックグランド

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

TL1A分子の別称

TL1A, VEGI, TNFSF15

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Duvakitug	TEV-48574; TEV-'574; TEV'574; SAR447189; SAR-447189; TEV574; TEV-574	Phase 3 Clinical	Teva Pharmaceutical Industries Ltd	Asthma; Colitis, Ulcerative; Crohn Disease	詳細
Tulisokibart	PRA-023; MK-7240; PRA023	Phase 3 Clinical	Merck Sharp & Dohme LLC, Prometheus Biosciences Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Colitis, Ulcerative; Crohn Disease; Hidradenitis Suppurativa; Inflammatory Bowel Diseases; Lung Diseases, Interstitial; Non-radiographic axial spondyloarthritis; Scleroderma, Diffuse; Spondylitis, Ankylosing	詳細
Afimkibart	PF-06480605; PF 6480605; RVT-3101; RG-6631; RO-7790121	Phase 3 Clinical	Pfizer Inc	Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Inflammatory Bowel Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease	詳細
RO-7837195	RO-7837195; RO7837195	Phase 2 Clinical	Genentech Inc	Colitis, Ulcerative	詳細
PF-07261271	RG-6730; PF-07261271	Phase 2 Clinical	Pfizer Inc	Inflammatory Bowel Diseases	詳細
SPY0-72	SPY002-072; SPY0-72	Phase 2 Clinical	Spyre Therapeutics Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Joint Diseases; Rheumatic Diseases	詳細
XmAb-942	XmAb942; XmAb-942	Phase 2 Clinical	Xencor Inc	Colitis, Ulcerative; Inflammatory Bowel Diseases	詳細
BCD-261	BCD-261	Phase 2 Clinical	BIOCAD JSC	Colitis, Ulcerative; Crohn Disease; Inflammatory Bowel Diseases	詳細
next-generation anti-TL1A mAb (Pfizer)		Phase 1 Clinical	Pfizer Inc	Fibrosis; Inflammation	詳細
ENV-6946	ENV-6946	Phase 1 Clinical	Enveda Biosciences Inc	Inflammatory Bowel Diseases	詳細
QX-030N	QX030N; CLD-423; QX-030N	Phase 1 Clinical	Qyuns Therapeutics Co Ltd	Autoimmune Diseases; Inflammatory Bowel Diseases	詳細
HXN-1001	HXN-1001	Phase 1 Clinical	Helixon Ltd	Inflammatory Bowel Diseases; Psoriasis	詳細
GR-2303	GR-2303	Phase 1 Clinical	Chongqing Genrix Biopharmaceutical Co Ltd	Inflammatory Bowel Diseases	詳細
SSGJ-627	SSGJ-627; SSGJ627	Phase 1 Clinical	Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd	Colitis, Ulcerative	詳細
SPY-002	SPY002-091; SPY002 072; SPY-002; PR-010	Phase 1 Clinical	Paragon Therapeutics Inc		詳細
ABS-101(Absci)	ABS-101(Absci); ABS-101	Phase 1 Clinical	Absci Corp	Inflammatory Bowel Diseases	詳細
FG-M701	FG-M-701; ABBV-701; FG-M701	Phase 1 Clinical	FutureGen Biopharm (Beijing) Co Ltd	Autoimmune Diseases	詳細
Next-generation anti-TL1A antibody(Telavant)		Phase 1 Clinical	Telavant Inc	Fibrosis; Inflammation	詳細

レビュー

S***e2025-09-13
1評価
Human TL1A / TNFSF15 Protein, His Tag, active trimer, low endotoxin (MALS verified)
Worked all times I have used this product with very reproducible data! Also appreciated the very quick shipping.
A***e2025-04-10
0評価
Human TL1A / TNFSF15 Protein, His Tag, active trimer, low endotoxin (MALS verified)
I used the TL1A in multiple experiments and the results were always consistent and reproducible. Different lots were used throughout a year long timeline and the results did not differ between lots. When shipping there was not ever any damaged packaging that could impact product quality. I have used Acrobiosystems in my professional career multiple times over multiple years and have always had success :) I will continue to use Acro as a trusted supplier.
E***r2024-08-08
2評価
Human TL1A / TNFSF15 Protein, His Tag, active trimer, low endotoxin (MALS verified)
This protein showed good activity in cell reporter assays and could be used routinely in inhibition assays.