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TREM-1

TREM-1 Overview

English Name	Triggering receptor expressed on myeloid cells 1	Approved Drugs	0
Drugs in Clinical Trials	6	Target Synonym	Triggering Receptor Expressed On Myeloid Cells 1，CD354 Antigen，Triggering Receptor Expressed on Myeloid Cells-1，TREM-1，TREM1，CD354，Triggering receptor expressed on monocytes 1
Highest Development Stage	Phase 2 Clinical

English Name	Triggering receptor expressed on myeloid cells 1
Target Synonym	Triggering Receptor Expressed On Myeloid Cells 1，CD354 Antigen，Triggering Receptor Expressed on Myeloid Cells-1，TREM-1，TREM1，CD354，Triggering receptor expressed on monocytes 1
Approved Drugs	0
Drugs in Clinical Trials	6
Highest Development Stage	Phase 2 Clinical

TREM-1 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Fc Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
TR1-H5251	Human	HEK293	Human TREM-1 / CD354 Protein, Fc Tag, low endotoxin

Total: 1

TREM-1 Background

Triggering receptor expressed on myeloid cells 1 (TREM1) is also known as CD antigen CD354, and is a type I transmembrane protein with a single Ig-like domain. TREM1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. TREM-1 / CD354 stimulates neutrophil and monocyte-mediated inflammatory responses, and also triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. TREM1 can interacts with TYROBP / DAP12.

TREM-1 Synonyms

TREM1,CD354

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Nangibotide	LR-12	Phase 2 Clinical	Inotrem	Coronavirus Disease 2019 (COVID-19); Shock, Septic	Details
ABBV-8736	ABBV-8736	Phase 2 Clinical	Abbvie Inc	Crohn Disease; Inflammatory Bowel Diseases	Details
TREM-1 antibody (Boehringer Ingelheim)		Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Autoimmune Diseases	Details
CEL383	CEL-383	Phase 1 Clinical	Celsius Therapeutics Inc	Inflammatory Bowel Diseases	Details
TREM 1 antibody(Boehringer Ingelheim International Gmbh)	TREM 1 antibody(Boehringer Ingelheim International Gmbh)	Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Immune System Diseases	Details
PY-159	PY-159	Phase 1 Clinical	Centre for the Commercialization of Antibodies and Biologics	Neoplasms; Solid tumours	Details