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TrkA

TrkA 詳細

英語名	Nerve growth factor receptor Trk-A	市販薬剤の数	5
治験薬の数	24	ターゲットの別称	P140-TrkA，Gp140trk，MTC，TRK，Oncogene TRK，EC 2.7.10.1，TRK1，Receptor， trkA，High Affinity Nerve Growth Factor Receptor，Tropomyosin-Related Kinase A，TRKA，Trk-A，Tyrosine kinase receptor，Neurotrophic Receptor Tyrosine Kinase 1，Neurotrophic Tyrosine Kinase， Receptor， Type 1，EC 2.7.10，EC:2.7.10.1，NTRK1，Neurotrophic tyrosine kinase receptor type 1，TRK1-transforming tyrosine kinase protein，Tyrosine kinase receptor A
研究＆開発段階	Approved

英語名	Nerve growth factor receptor Trk-A
ターゲットの別称	P140-TrkA，Gp140trk，MTC，TRK，Oncogene TRK，EC 2.7.10.1，TRK1，Receptor， trkA，High Affinity Nerve Growth Factor Receptor，Tropomyosin-Related Kinase A，TRKA，Trk-A，Tyrosine kinase receptor，Neurotrophic Receptor Tyrosine Kinase 1，Neurotrophic Tyrosine Kinase， Receptor， Type 1，EC 2.7.10，EC:2.7.10.1，NTRK1，Neurotrophic tyrosine kinase receptor type 1，TRK1-transforming tyrosine kinase protein，Tyrosine kinase receptor A
市販薬剤の数	5
治験薬の数	24
研究＆開発段階	Approved

TrkA 製品リスト

属性
Protein (2)Cell (2)
製品ライブラリ
オンライン (4)
種
Human (4)
タグ
Mouse IgG Fc Tag (2)- (1)Tag Free (1)
マーカー
Unconjugated (2)- (2)

製品番号	種	発現システム	製品説明
HOT TRA-H5259	Human	HEK293	Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag
CHEK-ATF093	Human	HEK293	Human TrkA (Luc) HEK293 Reporter Cell
CHEK-ATP192	Human	HEK293	HEK293/Human TrkA Stable Cell Line
TRA-H5253	Human	HEK293	Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag

総数量4

TrkAバックグランド

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

TrkA分子の別称

TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Tavilermide	MIM-D3; NMG938VJ6T (UNII code)	Phase 3 Clinical	Mimetogen Pharmaceuticals	Dry Eye Syndromes; Keratoconjunctivitis Sicca; Xerophthalmia	詳細
Lestaurtinib	SPM-924; A-154475.0; KT-5555; SP-924; CEP-701	Phase 3 Clinical	Kyowa Hakko Kirin Co Ltd	Bone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential	詳細
SNA-125	CT-340; SNA-125	Phase 2 Clinical	Creabilis Sa, Sienna Biopharmaceuticals Inc	Dermatitis, Atopic; Pruritus; Psoriasis	詳細
OPN-7486	PLX-7486; PLX7486-TsOH	Phase 2 Clinical	Plexxikon Inc	Giant Cell Tumor of Tendon Sheath; Neoplasms; Solid tumours	詳細
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	詳細
Milciclib maleate	PHA-848125; TZLS-201; PHA-848125C; PHA-125; PHA-848125AC	Phase 2 Clinical	Nerviano Medical Sciences Srl, Tiziana Life Sciences Plc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Solid tumours; Thymoma	詳細
FCN-011	FCN-011	Phase 2 Clinical		Solid tumours	詳細
Recombinant human nerve growth factor (Xintrum Pharmacouticals)	rh-NGF; ZX1305; ZX-1305; ZX1305E; ZX-1305-E	Phase 2 Clinical	Jiangsu Zhongxin Pharmaceutical Co Ltd	Glaucoma, Open-Angle; Keratitis; Optic Nerve Injuries	詳細
AK-1830	AK-1830; ARRY-954	Phase 2 Clinical	Array Biopharma	Low Back Pain	詳細
CNTX-0066	CNTX-0066	Phase 2 Clinical	Centrexion Therapeutics Corp	Osteoarthritis, Knee	詳細
STSP-0902	STSP-0902; STSP0902	Phase 2 Clinical	Staidson(Beijing) Biopharmaceuticals Co Ltd	Asthenozoospermia; Keratitis; Neurotrophic Keratitis; Oligospermia	詳細
BEN-2293	BEN-00002293; BEN-2293	Phase 2 Clinical	Benevolentai Bio Ltd	Dermatitis, Atopic	詳細
VMD-928	VMD-928	Phase 2 Clinical	Vm Oncology Llc	Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Head and Neck Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mesothelioma; Pancreatic Neoplasms; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
Emzeltrectinib	CT-3417; TQB-3558	Phase 1 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Solid tumours	詳細
BPI-28592	BPI-28592	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Neoplasm Metastasis; Solid tumours	詳細
ACD-856	ACD-856	Phase 1 Clinical	Alzecure Pharma Ab	Alzheimer Disease; Cognition Disorders	詳細
HG-030	HG-030	Phase 1 Clinical	Hitgen Inc	Solid tumours	詳細
CSCJC-3456	CSCJC3456; CSCJC-3456	Phase 1 Clinical	Changshan ConjuChem BioPharmaceutical Research and Development (Hebei) Co Ltd, Hebei Changshan Biochemical Pharmaceutical Co Ltd	Solid tumours	詳細
BR-01T	BR01T; BR-01T	Phase 1 Clinical	Xiyuan Anjian Pharmaceutical (Shanghai) Co Ltd	Low Back Pain	詳細
HT006.2.2	HT006.2.2; HT-006.2.2	Phase 1 Clinical	Wuhan Hiteck Biological Pharma Co Ltd	Keratitis	詳細
T-1301	T-1301; DBPR-216; BPR-1J481; BPR1J481	Phase 1 Clinical	Taivex Therapeutics Corp	Lymphoma; Solid tumours	詳細
Paltimatrectinib	PBI-200	Phase 1 Clinical	Pyramid Biosciences	Brain Neoplasms; Desmoplastic Small Round Cell Tumor; Solid tumours	詳細
FCN-098	FCN-098; FCN098	Phase 1 Clinical		Neoplasms; Solid tumours	詳細
E-2511	E2511; E-2511	Phase 1 Clinical	Eisai Inc		詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Taletrectinib Adipate	DS-6051b; DS-6051a; DS-6051; AB-106; IBI-344	Approved	Daiichi Sankyo Co Ltd	达伯乐, DOVBLERON, IBTROZI	Mainland China	Carcinoma, Non-Small-Cell Lung	AnHeart Therapeutics Co Ltd	2024-12-17	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Neoplasms; Solid tumours	詳細
Entrectinib	NMS-E628; RXDX-101; RG-6268	Approved	Nerviano Medical Sciences Srl	Rozlytrek, 罗圣全	Japan	Carcinoma, Non-Small-Cell Lung	Chugai Pharmaceutical Co Ltd	2019-06-18	Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Sarcoma; Solid tumours; Thyroid Cancer, Papillary	詳細
Regorafenib	DAST; BAY-73-4506	Approved	Bayer AG	Stivarga, Resihance	United States	Colorectal Neoplasms	Bayer Healthcare Pharmaceuticals Inc	2012-09-27	Adenocarcinoma; Adenoma; Bile Duct Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrinoma; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glucagonoma; Hemangiosarcoma; Insulinoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Meningioma; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma; Sarcoma, Ewing; Solid tumours; Somatostatinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms	詳細
Larotrectinib sulfate	LOXO-101; ARRY-470; BAY-2757556	Approved	Array Biopharma	Vitrakvi, 维泰凯	United States	Solid tumours	Bayer Healthcare	2018-11-26	Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Leukemia; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile	詳細
Repotrectinib	TPX-0005; BMS-986472; ZL-2308	Approved	Turning Point Therapeutics Inc	Augtyro, 奥凯乐	United States	Carcinoma, Non-Small-Cell Lung	Bristol-Myers Squibb Company	2023-11-15	Brain metastases; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Neoplasms; Solid tumours	詳細