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TrkB

TrkB 詳細

英語名Neurotrophic tyrosine kinase receptor type 2市販薬剤の数5
治験薬の数13ターゲットの別称EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
研究＆開発段階Approved
英語名Neurotrophic tyrosine kinase receptor type 2
ターゲットの別称EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
市販薬剤の数5
治験薬の数13
研究＆開発段階Approved

TrkB 製品リスト

  • 属性

    Protein (3)Cell (2)

  • 製品ライブラリ

    オンライン (5)

  • 種

    Human (5)

  • タグ

    Fc Tag (1)His Tag (1)Tag Free (1)His Tag & Avi Tag (1)- (1)

  • マーカー

    Unconjugated (2)- (2)Biotin-labeled (1)

製品番号種発現システム製品説明タンパク質の構造純度特性
CHEK-ATF289
Human
HEK293
Human TrkB (Luc) HEK293 Reporter Cell
CHEK-ATP082
Human
HEK293
HEK293/Human TrkB Stable Cell Line
NT2-H5228
Human
HEK293
Human TrkB / NTRK2 Protein, His Tag
NT2-H5254
Human
HEK293
Human TrkB / NTRK2 Protein, Fc Tag
NT2-H82E3
Human
HEK293
Biotinylated Human TrkB / NTRK2 Protein, His,Avitag™ (MALS verified)
総数量5
  • 1
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TrkBバックグランド

This gene encodes a member of the neurotrophic tyrosine receptor kinase(NTRK)family.This kinase is a membrane-bound receptor that upon neurotrophin binding,phosphorylates itself and members of the MAPK pathway.Signalling through this kinase leads to cell differentiation.Mutations in this gene have been associated with obesity and mood disorders.

TrkB分子の別称

NTRK2,TRKB,GP145-TrkB

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
LestaurtinibSPM-924; A-154475.0; KT-5555; SP-924; CEP-701Phase 3 ClinicalKyowa Hakko Kirin Co LtdBone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential
詳細
Merestinib5OGS5K699E; LY-2801653Phase 2 ClinicalEli Lilly And CompanyBiliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours
詳細
FCN-011FCN-011Phase 2 ClinicalSolid tumours
詳細
MT-200605MT-200605; MT200605Phase 2 ClinicalShaanxi Micot Pharmaceutical Technology Co LtdBrain Injuries; Ischemic Stroke; Nervous System Diseases; Obesity; Overweight; Stroke
詳細
EmzeltrectinibCT-3417; TQB-3558Phase 1 ClinicalBeijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co LtdSolid tumours
詳細
ACD-856ACD-856Phase 1 ClinicalAlzecure Pharma AbAlzheimer Disease; Cognition Disorders
詳細
HG-030HG-030Phase 1 ClinicalHitgen IncSolid tumours
詳細
FB_-1002FB_-1002; FB-1002; 4B02-01Phase 1 Clinical4b Technologies (Suzhou) LtdAmyotrophic Lateral Sclerosis; Depressive Disorder
詳細
FB-1001FB_-1001; FB-1001; FB1001Phase 1 Clinical4b Technologies (Suzhou) LtdGlaucoma; Glaucoma, Angle-Closure; Optic Nerve Diseases; Optic Neuropathy, Ischemic
詳細
1-D-2281D228; 1-D-228Phase 1 ClinicalGuangdong Lewwin Pharmaceutical Research Institute Co Ltd, Guangzhou Zhongkelian Pharmaceutical Research Co LtdCarcinoma, Non-Small-Cell Lung
詳細
BrAD-R13BrAD-R13; BrADR13Phase 1 ClinicalShenzhen Braegen Pharmaceutical Co LtdAlzheimer Disease
詳細
T-1301T-1301; DBPR-216; BPR-1J481; BPR1J481Phase 1 ClinicalTaivex Therapeutics CorpLymphoma; Solid tumours
詳細
PaltimatrectinibPBI-200Phase 1 ClinicalPyramid BiosciencesBrain Neoplasms; Desmoplastic Small Round Cell Tumor; Solid tumours
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Taletrectinib AdipateDS-6051b; DS-6051a; DS-6051; AB-106; IBI-344ApprovedDaiichi Sankyo Co Ltd达伯乐, DOVBLERON, IBTROZIMainland ChinaCarcinoma, Non-Small-Cell LungAnHeart Therapeutics Co Ltd2024-12-17Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Neoplasms; Solid tumours
詳細
EntrectinibNMS-E628; RXDX-101; RG-6268ApprovedNerviano Medical Sciences SrlRozlytrek, 罗圣全JapanCarcinoma, Non-Small-Cell LungChugai Pharmaceutical Co Ltd2019-06-18Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Sarcoma; Solid tumours; Thyroid Cancer, Papillary
詳細
Larotrectinib sulfateLOXO-101; ARRY-470; BAY-2757556ApprovedArray BiopharmaVitrakvi, 维泰凯United StatesSolid tumoursBayer Healthcare2018-11-26Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Leukemia; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile
詳細
RepotrectinibTPX-0005; BMS-986472; ZL-2308ApprovedTurning Point Therapeutics IncAugtyro, 奥凯乐United StatesCarcinoma, Non-Small-Cell LungBristol-Myers Squibb Company2023-11-15Brain metastases; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Neoplasms; Solid tumours
詳細
Cabozantinib S-malateXL-184; BMS-907351; RO7047650; RO-7047650ApprovedExelixis IncCometriq, CabometyxUnited StatesThyroid Neoplasms; Carcinoma, NeuroendocrineExelixis Inc2012-11-29Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin
詳細
  • 詳細
  • 製品リスト
  • 市販薬剤に関する情報
  • 治験薬に関する情報