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USAG-1

USAG-1 Overview

English Name	Sclerostin domain-containing protein 1	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	SOSTDC1，CDA019，USAG1，Sclerostin Domain Containing 1，DAND7，Sclerostin Domain-Containing Protein 1，Ectodermal BMP Inhibitor，DKFZp564D206，Ectodin，Wise，Uterine Sensitization-Associated Gene 1 Protein，Uterine Sensitization-Associated Protein-1，Cystine-Knot Containing Secreted Protein，ECTODIN
Highest Development Stage	Preclinical

English Name	Sclerostin domain-containing protein 1
Target Synonym	SOSTDC1，CDA019，USAG1，Sclerostin Domain Containing 1，DAND7，Sclerostin Domain-Containing Protein 1，Ectodermal BMP Inhibitor，DKFZp564D206，Ectodin，Wise，Uterine Sensitization-Associated Gene 1 Protein，Uterine Sensitization-Associated Protein-1，Cystine-Knot Containing Secreted Protein，ECTODIN
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

USAG-1 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Fc Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
US1-H5254	Human	HEK293	Human USAG-1 Protein, Fc Tag

Total: 1

USAG-1 Background

USAG1 (uterine sensitization associated gene 1), also known asSOSTDC1 (sclerostin domain–containing 1), Ectodin, is a secreted protein with a glycosylated N-terminus that contains a C-terminal cysteine knot domain. This C-terminal cysteine knot domain is present in numerous growth factors, including TGFβ, NGF, PDGF, vWF, NDP, and mucin-2, and involved in dimerization, receptor binding, and signal transduction. SOSTDC1 negatively regulates BMP signaling during cellular proliferation, differentiation, and apoptosis in several biological processes (such as dentary morphogenesis, embryo implantation in the endo-metrium, and healing of bone fractures) [8]. In addition, SOSTDC1 might also involve cancer development processes through the regulation of the Wnt pathway.