HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9)

  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells
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製品番号/仕様
価格
数量
PBD-PLMY2212-100ug
$370.00
PBD-PLMY2212-1mg
$2388.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Source

    HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9) is a recombinant rabbit monoclonal antibody expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    1M1F9

  • Isotype

    Rabbit IgG, Kappa

  • Immunogen

    PBD-BSA

  • Conjugate

    HRP Labeled

  • Specificity

    Specifically recognizes PBD.

  • Application

    Application
    Recommended Usage
    ELISA
    1:600-1:6000
  • Purification

    Protein A purified / Protein G purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • Bioactivity-ELISA

     PBD ELISA

    Immobilized Human CD19 (20-291), Fc Tag, premium grade (Cat. No. CD9-H5251) at 5 μg/mL, add Loncastuximab tesirine and then add HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9) (Cat. No. PBD-PLMY2212) at 0.5 μg/mL (QC tested).

    Protocol

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バックグランド

Pyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibody-drug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNA-targeting payloads. Anti-PBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The anti-PBD antibody is a useful reagent in PK assay to determine conjugated antibodies.

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