Biotinylated Mouse Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)

Customer Reviews
Cat. No. / Size
Price
Qty
CA7-M82E7-25ug
$505.00
CA7-M82E7-200ug
$1845.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Cadherin-17, CDH17, HPT-1, LI-cadherin

  • Source

    Biotinylated Mouse Cadherin-17 Protein, His,Avitag (CA7-M82E7) is expressed from human 293 cells (HEK293). It contains AA Phe 26 - Met 786 (Accession # Q9R100-1).

    Predicted N-terminus: Phe 26

    Request for sequence
  • Molecular Characterization

    Cadherin-17 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 87.9 kDa. The protein migrates as 110-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

Customers Also Viewed

Performance Data

  • SDS-PAGE

    Cadherin-17 SDS-PAGE

    Biotinylated Mouse Cadherin-17 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    Cadherin-17 SEC-MALS

    The purity of Biotinylated Mouse Cadherin-17 Protein, His,Avitag (Cat. No. CA7-M82E7) is more than 95% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Cadherin-17 ELISA

    Immobilized Biotinylated Mouse Cadherin-17 Protein, His,Avitag (Cat. No. CA7-M82E7) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind various dilution ratio of Rabbit Anti-Cadherin 17 (QC tested).

    Protocol

Customer Reviews
Writing Reviews

Background

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Recent Advances

 
Drug Development Progress
  • English Name:

    Cadherin-17

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    17 Details

  • Highest Development Stage:

    Phase 2 Clinical

Contact Us
Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Customers Also Viewed
  • Performance Data
  • Customer Reviews
  • Background
Contact Us

お問い合わせ
グローバル:+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8