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CTGF

CTGF 詳細

英語名	Connective tissue growth factor	市販薬剤の数	1
治験薬の数	5	ターゲットの別称	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
研究＆開発段階	Approved

英語名	Connective tissue growth factor
ターゲットの別称	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
市販薬剤の数	1
治験薬の数	5
研究＆開発段階	Approved

CTGF 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (3)Mouse (1)Rhesus macaque (1)
タグ
His Tag & Avi Tag (1)His Tag (3)Fc Tag (1)
マーカー
Biotin-labeled (1)Unconjugated (4)

製品番号	種	発現システム	製品説明
HOT CTF-H52H5	Human	HEK293	Human CTGF / CCN2 Protein, His Tag
HOT CTF-H82E6	Human	HEK293	Biotinylated Human CTGF / CCN2 Protein, His,Avitag™ (recommended for biopanning)
HOT GTF-H5253	Human	HEK293	Human CTGF / CCN2 Protein, Fc Tag
HOT GTF-R52H4	Rhesus macaque	HEK293	Rhesus macaque CTGF / CCN2 Protein, His Tag
CTF-M52Hc	Mouse	HEK293	Mouse CTGF / CCN2 Protein, His Tag

総数量5

CTGFバックグランド

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF分子の別称

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Pamrevlumab	FG-3019	Phase 3 Clinical	Fibrogen Inc	Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerulosclerosis, Focal Segmental; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Muscular Dystrophy, Duchenne; Pancreatic Neoplasms	詳細
OLX-10010	cp-asiCTGF; OLX-101A; OLX-10010; BMT-101; OLX-101	Phase 2 Clinical	Olix Pharmaceuticals Inc	Cicatrix, Hypertrophic; Macular Degeneration; Pulmonary Fibrosis; Wet Macular Degeneration	詳細
SHR-1906	SHR-1906	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis	詳細
PRS-220	PRS-220	Phase 1 Clinical	Pieris Pharmaceuticals	Idiopathic Pulmonary Fibrosis	詳細
LEM-S401	LEM-S401; LEMS401	Phase 1 Clinical	Lemonex Inc	Cicatrix	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Penicillamine		Approved	Valeant	Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol	United States	Arthritis, Rheumatoid; Hepatolenticular Degeneration; Cystinuria	Bausch Health Companies Inc	1970-12-04	Arthritis, Rheumatoid; Cystinuria; Heavy Metal Poisoning; Hepatolenticular Degeneration; Lead Poisoning	詳細