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CTGF

CTGF Overview

English Name	Connective tissue growth factor	Approved Drugs	1
Drugs in Clinical Trials	5	Target Synonym	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
Highest Development Stage	Approved

English Name	Connective tissue growth factor
Target Synonym	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
Approved Drugs	1
Drugs in Clinical Trials	5
Highest Development Stage	Approved

CTGF Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (3)Mouse (1)Rhesus macaque (1)
Tag
His Tag & Avi Tag (1)His Tag (3)Fc Tag (1)
Conjugate
Biotin-labeled (1)Unconjugated (4)

Cat. No.	Species	Host	Product Description
HOT CTF-H52H5	Human	HEK293	Human CTGF / CCN2 Protein, His Tag
HOT CTF-H82E6	Human	HEK293	Biotinylated Human CTGF / CCN2 Protein, His,Avitag™ (recommended for biopanning)
HOT GTF-H5253	Human	HEK293	Human CTGF / CCN2 Protein, Fc Tag
HOT GTF-R52H4	Rhesus macaque	HEK293	Rhesus macaque CTGF / CCN2 Protein, His Tag
CTF-M52Hc	Mouse	HEK293	Mouse CTGF / CCN2 Protein, His Tag

Total: 5

CTGF Background

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF Synonyms

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Pamrevlumab	FG-3019	Phase 3 Clinical	Fibrogen Inc	Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerulosclerosis, Focal Segmental; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Muscular Dystrophy, Duchenne; Pancreatic Neoplasms	Details
OLX-10010	cp-asiCTGF; OLX-101A; OLX-10010; BMT-101; OLX-101	Phase 2 Clinical	Olix Pharmaceuticals Inc	Cicatrix, Hypertrophic; Macular Degeneration; Pulmonary Fibrosis; Wet Macular Degeneration	Details
SHR-1906	SHR-1906	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis	Details
PRS-220	PRS-220	Phase 1 Clinical	Pieris Pharmaceuticals	Idiopathic Pulmonary Fibrosis	Details
LEM-S401	LEM-S401; LEMS401	Phase 1 Clinical	Lemonex Inc	Cicatrix	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Penicillamine		Approved	Valeant	Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol	United States	Arthritis, Rheumatoid; Hepatolenticular Degeneration; Cystinuria	Bausch Health Companies Inc	1970-12-04	Arthritis, Rheumatoid; Cystinuria; Heavy Metal Poisoning; Hepatolenticular Degeneration; Lead Poisoning	Details