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Activin RIIA

Activin RIIA Overview

English Name	Activin receptor type-2A	Approved Drugs	0
Drugs in Clinical Trials	4	Target Synonym	Activin receptor type IIA，ACTR-IIA，ACTRIIA，ACVR2
Highest Development Stage	Phase 2 Clinical

English Name	Activin receptor type-2A
Target Synonym	Activin receptor type IIA，ACTR-IIA，ACTRIIA，ACVR2
Approved Drugs	0
Drugs in Clinical Trials	4
Highest Development Stage	Phase 2 Clinical

Activin RIIA Product List

Product Category
Protein (7)
Product Status
Launched (7)
Species
Human / Cynomolgus (4)Mouse (2)Rabbit (1)
Tag
Fc Tag (1)His Tag & Avi Tag (2)His Tag (3)Avi Tag & Fc Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (3)

Cat. No.	Species	Host	Product Description
ACA-M52H3	Mouse	HEK293	Mouse Activin RIIA / ACVR2A Protein, His Tag, low endotoxin (SPR & HPLC verified)
ACA-M82E3	Mouse	HEK293	Biotinylated Mouse Activin RIIA Protein, His,Avitag™ (MALS verified)
ACA-H5243	Human / Cynomolgus	HEK293	Human / Cynomolgus Activin RIIA / ACVR2A Protein, His Tag, low endotoxin (MALS & SPR verified)
ACA-H5269	Human / Cynomolgus	HEK293	Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag
ACA-H82F4	Human / Cynomolgus	HEK293	Biotinylated Human / Cynomolgus Activin RIIA Protein, Avitag™,Fc Tag (MALS verified)
ACA-H82Q3	Human / Cynomolgus	HEK293	Biotinylated Human / Cynomolgus Activin RIIA Protein, His,Avitag™
ACA-R52H3	Rabbit	HEK293	Rabbit Activin RIIA / ACVR2A Protein, His Tag (MALS verified)

Total: 7

Activin RIIA Background

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Activin RIIA Synonyms

Activin receptor type IIA,ACTRIIA

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
LAE-102	LAE-102	Phase 2 Clinical	Laekna Therapeutics Shanghai Co Ltd	Carcinoma, Non-Small-Cell Lung; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight; Solid tumours	Details
SSS-67	SSS67; SSS-67	Phase 1 Clinical	Shenyang Sunshine Pharmaceutical Co Ltd	Obesity; Overweight	Details
JMT-206	JMT206; JMT-206	Phase 1 Clinical	Shanghai Jmt-Bio Inc	Body Weight; Obesity; Overweight; Sarcopenia	Details
IMC-003(ImmuneOnco Biopharmaceuticals)	IMM72; IMM-72; IMC-003; IMC-003(ImmuneOnco Biopharmaceuticals)	Phase 1 Clinical		Pulmonary Arterial Hypertension	Details

Product Reviews

L***i2024-11-05
1People Like
Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag
We have been purchasing Activin products from Acro for a few years now and have always appreciated the quality and consistency. We were excited to see that biotinylated options are now available, as they fit our research needs perfectly. Acro's reliable service keeps us coming back as satisfied customers, and we look forward to using these new products.
A***z2022-06-15
0People Like
Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag
The product quality was excellent. The technical services was better than all competitors and the logistics speed was very fast. All in all, a fantastic product and a fantastic company.