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Cathepsin B

Cathepsin B 詳細

英語名	Cathepsin B	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	EC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB
研究＆開発段階	Phase 2 Clinical

英語名	Cathepsin B
ターゲットの別称	EC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

Cathepsin B 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (3)Tag Free (1)
マーカー
Unconjugated (4)

製品番号	種	発現システム	製品説明
CTB-H5213	Human	HEK293	Human Cathepsin B / CTSB (L26V) Protein, Tag Free (Pro-form, MALS verified)
CTB-H5222	Human	HEK293	Human Cathepsin B / CTSB Protein, His Tag (Pro-form, MALS verified)
CTB-H52H3	Human	HEK293	Human Cathepsin B / CTSB (18-339) Protein, His Tag (Pro-form, MALS verified)
CTB-M52H9	Mouse	HEK293	Mouse Cathepsin B / CTSB Protein, His Tag (Pro-form, MALS verified)

総数量4

Cathepsin Bバックグランド

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B分子の別称

CTSB,CPSB,APPS

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Osugacestat	AL-101(BMS); BMS-906024; BM-0018	Phase 2 Clinical	Bristol-Myers Squibb Company, Glaxosmithkline Plc	Carcinoma, Adenoid Cystic; Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Triple Negative Breast Neoplasms	詳細
cysteine protease inhibitor (Boehringer Ingelheim)		Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Respiratory Tract Diseases	詳細

レビュー

M***i2025-04-05
0評価
Human Cathepsin B / CTSB Protein, His Tag (Pro-form, MALS verified)
Product was purchased to utilize in a val-cit cleavage assay for a protein-drug conjugate. The protein did not take long to arrive and the assay instructions were clear to follow and promptly given upon request. I was readily able to utilize the protein for the desired cleavage assay using the provided protocol and it worked great. I am satisified with the quality and the price of this reagent.