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CD117

CD117

CD117 詳細

Molecule Name
Stem cell growth factor receptor
分子の別称
CD117,SCFR,c-Kit,KIT
Drug Development Progress
治験薬の数37
市販薬剤の数17
研究＆開発段階Approved
ターゲットの別称
EC 2.7.10，EC:2.7.10.1，MASTC，KIT Proto-Oncogene Receptor Tyrosine Kinase，V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein，p145 c-kit，SCFR，KIT，Proto-Oncogene C-Kit，Proto-Oncogene Tyrosine-Protein Kinase Kit，Soluble KIT Variant 1，C-Kit Protooncogene，CD117 Antigen，Piebald Trait，EC 2.7.10.1，C-Kit，CD117，Proto-Oncogene Proteins c-kit，Mast/stem cell growth factor receptor Kit，PBT，Piebald trait protein，Tyrosine-protein kinase Kit，KIT Proto-Oncogene， Receptor Tyrosine Kinase，v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
バックグランド
c-KIT activation has been shown to have oncogenic activity in gastrointestinal stromal tumors (GISTs), melanomas, lung cancer, and other tumor types. The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in late-stage trials in melanoma and GIST. KIT overactivity can be the result of many genomic events from genomic amplification to overexpression to missense mutations. Missense mutations have been shown to be key players in mediating clinical response and acquired resistance in patients being treated with these targeted therapeutics.

CD117 製品リスト

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  • V***l2022-06-25
    Human CD117 / c-kit Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
    We used the c-Kit protein to immunizations projects we are carrying for our studies and they performed great. The delivery was also very fast and the purchasing process very easy. We also purchased several other antibodies and recombinant proteins that we are currently testing and they all have very good quality. I have not used directly the technical services because it was not necessary, as the website is very easy and informative, so I found the products we wanted with no problem.