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CD38

CD38 詳細

英語名	Lymphocyte differentiation antigen CD38	市販薬剤の数	3
治験薬の数	48	ターゲットの別称	EC:3.2.2.6，EC:2.4.99.20，2-Phospho-Cyclic-ADP-Ribose Transferase，Cyclic ADP-Ribose Hydrolase 1，2-Phospho-ADP-Ribosyl Cyclase，NAD(+) Nucleosidase，CD38 Antigen (P45)，2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase，Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase，ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1，Cluster Of Differentiation 38，CD38 Antigen，EC 2.4.99.20，EC 3.2.2.6，ADPRC1，T10，2'-phospho-ADP-ribosyl cyclase，ADPRC 1，cADPr hydrolase 1，ADP-ribosyl cyclase 1，2'-phospho-cyclic-ADP-ribose transferase，CD38，CD38 Molecule，2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
研究＆開発段階	Approved

英語名	Lymphocyte differentiation antigen CD38
ターゲットの別称	EC:3.2.2.6，EC:2.4.99.20，2-Phospho-Cyclic-ADP-Ribose Transferase，Cyclic ADP-Ribose Hydrolase 1，2-Phospho-ADP-Ribosyl Cyclase，NAD(+) Nucleosidase，CD38 Antigen (P45)，2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase，Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase，ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1，Cluster Of Differentiation 38，CD38 Antigen，EC 2.4.99.20，EC 3.2.2.6，ADPRC1，T10，2'-phospho-ADP-ribosyl cyclase，ADPRC 1，cADPr hydrolase 1，ADP-ribosyl cyclase 1，2'-phospho-cyclic-ADP-ribose transferase，CD38，CD38 Molecule，2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
市販薬剤の数	3
治験薬の数	48
研究＆開発段階	Approved

CD38 製品リスト

属性
Protein (10)Beads (1)Antibody (1)Kits (1)
製品ライブラリ
オンライン (13)
種
Human (10)Cynomolgus (1)Mouse (1)Rabbit (1)
タグ
His Tag (4)His Tag & Avi Tag (1)Fc Tag (2)Mouse IgG Fc Tag (1)- (3)Fc Tag & Avi Tag (1)Avi Tag (1)
マーカー
Unconjugated (6)Biotin-labeled (3)- (2)FITC Labeled (2)

製品番号	種	発現システム	製品説明
HOT CD8-H5224	Human	HEK293	Human CD38 Protein, His Tag (MALS verified)
HOT CD8-H5255	Human	HEK293	Human CD38 Protein, Fc Tag (MALS verified)
HOT CD8-H82E7	Human	HEK293	Biotinylated Human CD38 Protein, Avitag™,His Tag (MALS verified)
HOT CD8-HF2H5	Human	HEK293	FITC-Labeled Human CD38 Protein, His Tag (MALS verified)
CD8-H5253	Human	HEK293	Human CD38 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD8-H8214	Human	HEK293	Biotinylated Human CD38 Protein, Avitag™
CD8-H82F5	Human	HEK293	Biotinylated Human CD38 Protein, Fc,Avitag™ (MALS verified)
CD8-HF255	Human	HEK293	FITC-Labeled Human CD38 Protein, Fc Tag
CEA-B039	Human	-	Human Soluble CD38 ELISA Kit
MBC-K010	Human	-	Human CD38-coupled Magnetic Beads

総数量13

CD38バックグランド

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

CD38分子の別称

CD38,T10,cADPr hydrolase 1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Mezagitamab	TAK-079	Phase 3 Clinical	Takeda Pharmaceutical Co Ltd	Autoimmune Diseases; Glomerulonephritis; Glomerulonephritis, IGA; Kidney Diseases; Lupus Erythematosus, Systemic; Multiple Myeloma; Myasthenia Gravis; Nephrosis; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	詳細
Daratumumab biosimilar (Celltrion)	CT-P44	Phase 3 Clinical	Celltrion Inc	Multiple Myeloma	詳細
Daratumumab biosimilar (Biocad)	BCD-264	Phase 3 Clinical	BIOCAD JSC	Multiple Myeloma	詳細
SCTC-21-C	SCTC21C; SCTC-21-C; SCT-C21C	Phase 3 Clinical	SinoCelltech Ltd	Amyloidosis; Autoimmune Diseases; Glomerulonephritis, IGA; Hematologic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Lupus Erythematosus, Systemic; Multiple Myeloma	詳細
Daratumumab biosimilar (Henlius)	HLX-15	Phase 3 Clinical		Multiple Myeloma	詳細
Recombinant anti-CD38 fully human monoclonal antibody (Henlius Biotech)		Phase 3 Clinical		Amyloidosis; Multiple Myeloma	詳細
Recombinant human anti-CD38 momoclonal antibody(Sumgen)	SG-301; SG301	Phase 3 Clinical	Hangzhou Shangjian Biotechnology Co Ltd	Hematologic Neoplasms; Lupus Erythematosus, Systemic; Multiple Myeloma; Nephrotic Syndrome	詳細
STI-6129	STI-6129; LNDS-1001	Phase 2 Clinical	Sorrento Therapeutics Inc	Immunoglobulin Light-chain Amyloidosis; Leukemia, Myeloid, Acute; Multiple Myeloma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	詳細
Modakafusp alfa	TEV-48573; TAK-573	Phase 2 Clinical	Takeda Pharmaceutical Co Ltd	Melanoma; Multiple Myeloma; Neoplasms	詳細
CLL1/CD33/CD38/CD7 CAR-T cell therapy		Phase 2 Clinical	Guangzhou Bio-Gene Technology Co Ltd	Leukemia, Myeloid, Acute	詳細
Anti-CD38 Monoclonal Antibody (Genrix)		Phase 2 Clinical	Genrix (Shanghai) Biopharmaceutical Co Ltd	Multiple Myeloma	詳細
4SCAR-T cell therapy (Shenzhen Geno-Immune Medical Institute)	4SCAR-T	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Autoimmune Diseases; Hematologic Neoplasms; Neuroblastoma	詳細
REGN-7945	REGN7945; REGN-7945	Phase 2 Clinical	Regeneron Pharmaceuticals Inc	Multiple Myeloma	詳細
Anti-CD38 Antibody(Institute of Hematology & Blood Diseases Hospital)		Phase 2 Clinical	Institute Of Hematology & Blood Diseases Hospital	Antiphospholipid Syndrome; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	詳細
CID-103	TSK011010; CID-103	Phase 2 Clinical	Tusk Therapeutics Ltd	Multiple Myeloma; Purpura, Thrombocytopenic, Idiopathic; Rejection of renal transplantation; Thrombocytopenia	詳細
BHV-1100	KP-1237; BHV-1100	Phase 2 Clinical	Biohaven Pharmaceuticals Inc, Kleo Pharmaceuticals, PeptiDream Inc	Multiple Myeloma	詳細
Lumrotatug	CM-313	Phase 2 Clinical	Keymed Biosciences Co Ltd	Anemia; Anemia, Aplastic; Blood Platelet Disorders; Glomerulonephritis, IGA; Hematologic Neoplasms; Lupus Erythematosus, Systemic; Lymphoma; Multiple Myeloma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	詳細
89Zr-DFO-daratumumab		Phase 2 Clinical	Memorial Sloan Kettering Cancer Center	Multiple Myeloma	詳細
64Cu-DOTA-daratumumab		Phase 1 Clinical	City Of Hope National Medical Center	Multiple Myeloma	詳細
SAR-442257	SAR-442257	Phase 1 Clinical	Sanofi	Neoplasms	詳細
Anti-BCMA anti-CD38 bispecific chimeric antigen receptor T cell therapy (Shengyan Pharmaceutical Technology)		Phase 1 Clinical	Shengyan Pharmaceutical Technology	Multiple Myeloma	詳細
dual anti-BCMA/anti-CD38 CAR T-cell therapy (Shengyan Pharmaceutical Technology/Tongji Medical College)		Phase 1 Clinical	Tongji Medical College	Multiple Myeloma	詳細
CD38 CAR T-cells		Phase 1 Clinical	Zhejiang University	Hematologic Neoplasms; Leukemia, Myeloid, Acute	詳細
anti-CD38 CAR T-cell therapy (Shanghai Unicar-Therapy Bio-Medicine Technology/Soochow University/East China Normal University)		Phase 1 Clinical	Soochow University	Leukemia, Myeloid, Acute	詳細
actinium-225 labeled daratumumab (Actinium Pharmaceuticals)		Phase 1 Clinical	Actinium Pharmaceuticals Inc, City Of Hope National Medical Center, National Cancer Institute	Hematologic Neoplasms; Multiple Myeloma	詳細
T-007 (TNK Therapeutics/Celularity)		Phase 1 Clinical	Tnk Therapeutics Inc	Multiple Myeloma	詳細
Anti-CD38 chimeric antigen receptor T cell therapy(Yake Biotechnology)	CAR-T CD-38	Phase 1 Clinical	Shanghai YaKe Biotechnology Co Ltd	Leukemia, Myeloid, Acute; Multiple Myeloma	詳細
Indium In 111-DOTA-Daratumumab		Phase 1 Clinical	City Of Hope National Medical Center	Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
Daratumumab biosimilar (Jushi Biopharma)		Phase 1 Clinical	Jushi Biopharmaceutical Co Ltd	Multiple Myeloma	詳細
CD38\CS1 Chimeric Antigen Receptor T Cells therapy(The Second Hospital Of Shandong University)		Phase 1 Clinical	The Second Hospital Of Shandong University	Multiple Myeloma	詳細
SAR-444559	SAR444559; SAR-444559	Phase 1 Clinical	Sanofi	Inflammation	詳細
68Ga-NB-381	68Ga-NB381; 68Ga-NB-381; 18F-FDG(The First Affiliated Hospital Of Beijing University)	Phase 1 Clinical	The First Affiliated Hospital Of Beijing University	Multiple Myeloma	詳細
Dual CLL1/CD38 targeting CAR-T cell therapy (Gracell Biotechnologies)		Phase 1 Clinical	Gracell Biotechnologies (Shanghai) Co Ltd	Leukemia, Myeloid, Acute	詳細
Universal CAR-T Cells therapy(Shenzhen Geno-Immune Medical Institute)		Phase 1 Clinical	Shenzhen Geno-Immune Medical Institute	Leukemia, Myeloid, Acute	詳細
RB-0021	RB0021; RB-0021	Phase 1 Clinical	Ruiyang (Suzhou) Biological Technology Co Ltd	Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma	詳細
KJ-C2320	KJ-C2320	Phase 1 Clinical	CARsgen Therapeutics Holdings Ltd	Leukemia, Myeloid, Acute	詳細
Daratumumab biosimilar (Hangzhou Jiuyuan Gene Engineering)	JY43; JY-43	Phase 1 Clinical	Hangzhou Jiuyuan Gene Biomedical Co Ltd	Multiple Myeloma	詳細
KYS202002A	KYS-202002A; KYS202002A	Phase 1 Clinical	Jiangsu Kanion Pharmaceutical Co Ltd	Lupus Erythematosus, Systemic; Multiple Myeloma	詳細
ISB-2001	ISB-2001; ABBV-2001	Phase 1 Clinical	Ichnos Sciences Sa	Multiple Myeloma	詳細
TNB-738	TNB-738	Phase 1 Clinical	TeneoFour Inc		詳細
GBR-1342	GBR-1342; ISB-1342	Phase 1 Clinical	Glenmark Pharmaceuticals Ltd	Multiple Myeloma	詳細
XmAb-968	XmAb968	Phase 1 Clinical	Xencor Inc	Hematologic Neoplasms; Leukemia, Promyelocytic, Acute	詳細
XmAb-18968	XmAb-18968	Phase 1 Clinical	The Medical College Of Wisconsin Nonprofit	Leukemia, Myeloid, Acute	詳細
211At-OKT10-B10		Phase 1 Clinical	Fred Hutchinson Cancer Research Center	Multiple Myeloma	詳細
Y-150(Wuhan Yzy Biopharma/CSPC Pharmaceutical)	Y-150; Y150	Phase 1 Clinical	CSPC Pharmaceutical Group Ltd, Wuhan Yzy Biopharma Co Ltd	Multiple Myeloma	詳細
Anti CD38 chimeric antigen receptor T-cell therapy (Sorrento Therapeutics)		Phase 1 Clinical	Celularity Inc, Sorrento Therapeutics Inc	Multiple Myeloma	詳細
SAR-442085	SAR-442085	Phase 1 Clinical	Sanofi	Multiple Myeloma	詳細
111Indium labeled daratumumab			City Of Hope National Medical Center, National Cancer Institute		詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Daratumumab/Hyaluronidase-fihj	DARA-PH20	Approved	Johnson & Johnson Innovative Medicine	Darzalex Faspro, Darzquro, DARZALEX FASPRO, DARZALEX-SC	United States	Multiple Myeloma	Janssen Biotech Inc	2020-05-01	Amyloidosis; Anemia, Aplastic; Bone marrow transplant rejection; Hematologic Neoplasms; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Monoclonal Gammopathy of Undetermined Significance; Multiple Myeloma; Myelodysplastic Syndromes; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Rejection in heart transplantation; Smoldering Multiple Myeloma	詳細
Isatuximab	SAR-650984; hu38SB19	Approved	Immunogen Inc	Sarclisa	United States	Multiple Myeloma	Sanofi-Aventis U.S. Llc	2020-03-02	Amyloidosis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Carcinoma, Non-Small-Cell Lung; Constipation; Diarrhea; Gastrointestinal Hemorrhage; Goiter, Nodular; Hematologic Neoplasms; Hepatomegaly; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, T-Cell; Lymphadenopathy; Lymphoma; Lymphoma, Non-Hodgkin; Macroglossia; Multiple Myeloma; Nausea; Neoplasms; Paraproteinemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Purpura; Satiety Response; Smoldering Multiple Myeloma	詳細
Daratumumab	JNJ-54767414	Approved	Johnson & Johnson Innovative Medicine	Darzalex, 兆珂, 兆珂速	United States	Multiple Myeloma	Janssen Biotech Inc	2015-11-16	Alzheimer Disease; Amyloidosis; Anemia, Aplastic; Autoimmune Diseases; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Genital Neoplasms, Male; Glioblastoma; Glomerulonephritis; Hemangioma, Cavernous, Central Nervous System; Hodgkin Disease; Hypersensitivity; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Primary Effusion; Multiple Myeloma; Myelodysplastic Syndromes; Paraproteinemias; POEMS Syndrome; Prostatic Neoplasms; Purpura, Thrombocytopenic, Idiopathic; Rejection of renal transplantation; Rejection of organ transplantation; Renal Insufficiency; Skin Diseases; Smoldering Multiple Myeloma; Stevens-Johnson Syndrome; Urologic Neoplasms; Waldenstrom Macroglobulinemia	詳細

レビュー

Y***u2023-03-31
0評価
Biotinylated Human CD38 Protein, Avitag™,His Tag (MALS verified)
This product can be used at < 0.4 ug/ml as a detection agent to quantify anti CD38 antibodies in a binding assay. Anti CD38 antibodies in either bovine serum albumin based sample diluent or murine serum can be detected by this production without a problem. Specific signals from the subsequent streptavidin conjugated enzyme reaction were very strong and very low noise from the negative control antibody group.
Y***u2023-03-16
0評価
Mouse CD38 Protein, His Tag (MALS verified)
Used 3 ug/ml of this protein as the capture antigen in an ELISA assay to screen for anti-mouse CD38 mAbs. Very strong signal from the positive control anti-mouse CD38 mAb (clone: NIMR5) and no binding to several anti-human CD38 mAbs or the anti-IgG secondary Ab in the assay. The "ETD of in-stock products: 2 business days" statement on Acro website was accurate. Fast shipment. Professional COA and instructions on how to reconstitute and store this product.
1***02019-10-11
0評価
Human CD38 Protein, His Tag (MALS verified)
I bought a lot of products. This protein has high purity and good bioactivity. Whether it is for ELISA or functional assay, all went smoothly. The price is favorable and the service is also good. I support and recommend ACRO! Go ACRO!