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CD4

CD4 詳細

英語名	T-cell surface antigen CD4	市販薬剤の数	1
治験薬の数	25	ターゲットの別称	CD4mut，CD4 Antigens，T-cell surface antigen T4/Leu-3，T-cell surface glycoprotein CD4，CD4，CD4 Molecule，CD4 Antigen (P55)，CD4 Receptor，CD4 Antigen
研究＆開発段階	Approved

英語名	T-cell surface antigen CD4
ターゲットの別称	CD4mut，CD4 Antigens，T-cell surface antigen T4/Leu-3，T-cell surface glycoprotein CD4，CD4，CD4 Molecule，CD4 Antigen (P55)，CD4 Receptor，CD4 Antigen
市販薬剤の数	1
治験薬の数	25
研究＆開発段階	Approved

CD4 製品リスト

属性
Protein (15)Antibody (2)Cell Grade Beads (1)
製品ライブラリ
オンライン (18)
種
Human (13)Rhesus macaque (3)Rabbit (1)Mouse (1)
タグ
Fc Tag (3)His Tag (9)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)- (3)
マーカー
Unconjugated (5)Biotin-labeled (3)FITC Labeled (2)PE Labeled (2)APC Labeled (1)PE-CY7 Labeled (1)AF488 Labeled (2)AF647 Labeled (1)- (1)

製品番号	種	発現システム	製品説明
HOT CD4-H82E8	Human	HEK293	Biotinylated Human CD4 Protein, His,Avitag™ (MALS verified)
HOT CD4-HA2H9	Human	HEK293	APC-Labeled Human CD4 Protein, His TagStar Staining
HOT CD4-HF255	Human	HEK293	FITC-Labeled Human CD4 Protein, Fc Tag
HOT CD4-HP2E3	Human	HEK293	PE-Labeled Human CD4 Protein, His Tag (Site-specific conjugation)
HOT LE3-H5228	Human	HEK293	Human CD4 / LEU3 Protein, His Tag (MALS verified)
CD4-H5259	Human	HEK293	Human CD4 Protein, Fc Tag (MALS verified)
CD4-H82F3	Human	HEK293	Biotinylated Human CD4 Protein, Fc,Avitag™ (MALS verified)
CD4-HA225	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD4 Protein, His Tag
CD4-HA2H7	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD4 Protein, His TagStar Staining
CD4-HA2H8	Human	HEK293	Alexa Fluor™ 647-Labeled Human CD4 Protein, His TagStar Staining

総数量18

CD4バックグランド

T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

CD4分子の別称

CD4,CD4mut,LEU3

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Semzuvolimab	dB4; UB-421; mAb-B4	Phase 3 Clinical	United Biomedical Inc	HIV Infections	詳細
ITV 1(Nonindustrial source)	ITV-1	Phase 3 Clinical	Immunotech Laboratories, Synexa Life Sciences	HIV Infections	詳細
RB-0003	RB-0003; BNT-111	Phase 2 Clinical	Biontech Se, Tron	Melanoma	詳細
VRC-01-LS	VRC-HIVMAB-080-00-AB; VRC-01-LS	Phase 2 Clinical	National Institute Of Allergy And Infectious Diseases (Niaid)	HIV Infections	詳細
VRC-07-523	VRC-07-523-L S; VRC-HIVMAB075-00-AB; VRC-HIVMAB-075 -00-AB; VRC-07-523; TMB-380	Phase 2 Clinical	National Institute Of Allergy And Infectious Diseases (Niaid), Taimed Biologics Inc	Acquired Immunodeficiency Syndrome; HIV Infections; Sexually Transmitted Diseases, Viral	詳細
GEN-009	GEN-009	Phase 2 Clinical	Genocea Biosciences Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck	詳細
Tregalizumab	hB-F5; BT-061	Phase 2 Clinical	Biotest Pharma Gmbh	Arthritis, Rheumatoid; Asthma; Drug Hypersensitivity; Psoriasis	詳細
Lotivibart	VH-3810109; GSK-3810109-A; VH-109; N6LS; Z258‐N6LS; VRC-HIVMAB091-00-AB; GSK-3810109	Phase 2 Clinical	National Institute Of Allergy And Infectious Diseases (Niaid)	HIV Infections	詳細
MR-001	MR001; MR-001	Phase 2 Clinical	Shenzhen Maijiarui Biotechnology Co Ltd	Carcinoma, Pancreatic Ductal; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細
IMCY-0141	IMCY-0141	Phase 2 Clinical	Imcyse Sa	Multiple Sclerosis, Relapsing-Remitting	詳細
Autologous Regulatory Т-cell Therapy		Phase 2 Clinical	Institute Of Biophysics And Cell Engineering Of National Academy Of Sciences Of Belarus	Scleroderma, Systemic	詳細
TMB-365	TMB-365	Phase 2 Clinical	Taimed Biologics Inc	HIV Infections	詳細
CD4-directed chimeric antigen receptor engineered T-cells (Icell Gene)	CD4CAR (Icell Gene)	Phase 1 Clinical	Icell Gene Therapeutics (Int'L) Ltd, Stony Brook University School Of Medicine, University Of Louisville	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, T-Cell; Lymphoma, T-Cell	詳細
T-allo-10	T-allo-10	Phase 1 Clinical	Stanford University	Graft vs Host Disease; Hematologic Diseases; Hodgkin Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
Anti-CD4 CAR T-cell therapy (University of Pennsylvania)	CAR-C34ZFN	Phase 1 Clinical	University Of Pennsylvania	HIV Infections	詳細
10E8.4/iMab (Aaron Diamond AIDS Research Center)	TMB-370	Phase 1 Clinical	Aaron Diamond Aids Research Center For The City Of New York, Inc	HIV Infections	詳細
CD4CAR	ICG-122; CD4CAR	Phase 1 Clinical	iCell Gene Therapeutics LLC	Leukemia, Myelomonocytic, Chronic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Multiple Myeloma; Mycosis Fungoides; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	詳細
MazF gene therapy (Takara Bio)		Phase 1 Clinical	Takara Bio Inc	HIV Infections	詳細
CALRLong36 peptide (Herlev Hospital)		Phase 1 Clinical	Herlev Hospital	Myeloproliferative Disorders	詳細
VRC-HIVMAB060-00-AB	VRC-HIVMAB060-00-AB; VRC01	Phase 1 Clinical	National Institute Of Allergy And Infectious Diseases (Niaid)	HIV Infections	詳細
VRC-HIVMAB0115-00-AB		Phase 1 Clinical	National Institute Of Allergy And Infectious Diseases (Niaid)	HIV Infections	詳細
LM-49		Phase 1 Clinical	Shanxi Medical University, Shanxi University Of Traditional Chinese Medicine	Diabetic Nephropathies	詳細
SCRI-E2CAR_EGFRtv1	SCRI-E2CAR_EGFRtv1	Phase 1 Clinical	Umoja BioPharma Inc	Osteosarcoma	詳細
LB-1901	LB1901; LB-1901	Phase 1 Clinical		Leukemia, T-Cell; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral	詳細
IT-1208 (Kyowa Hakko Kirin)	IT-1208	Phase 1 Clinical	Kyowa Hakko Kirin Co Ltd	Neoplasms	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Ibalizumab	Hu5A8; TMB-355; TNX-355; 5AB	Approved	Biogen Inc	特罗格佐, Trogarzo	United States	HIV Infections	Theratechnologies Inc	2018-03-06	HIV Infections	詳細