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CD8 alpha

CD8 alpha 詳細

英語名	Cluster of differentiation 8	市販薬剤の数	0
治験薬の数	18	ターゲットの別称	CD8 Antigens
研究＆開発段階	Phase 3 Clinical

英語名	Cluster of differentiation 8
ターゲットの別称	CD8 Antigens
市販薬剤の数	0
治験薬の数	18
研究＆開発段階	Phase 3 Clinical

CD8 alpha 製品リスト

属性
Protein (13)
製品ライブラリ
オンライン (13)
種
Mouse (3)Human (8)Cynomolgus (2)
タグ
His Tag & Avi Tag (4)His Tag (8)Fc Tag (1)
マーカー
Biotin-labeled (3)Unconjugated (4)AF488 Labeled (3)AF647 Labeled (1)PE Labeled (1)APC Labeled (1)

製品番号	種	発現システム	製品説明
HOT CDA-H52H3	Human	HEK293	Human CD8 alpha / CD8A Protein, His Tag, low endotoxin (MALS verified)
HOT CDA-H82E3	Human	HEK293	Biotinylated Human CD8 alpha / CD8A Protein, His,Avitag™ (MALS verified)
HOT CDA-M82E8	Mouse	HEK293	Biotinylated Mouse CD8 alpha / CD8A Protein, His,Avitag™ (HPLC verified)
HOT CDA-C52H4	Cynomolgus	HEK293	Cynomolgus CD8 alpha / CD8A Protein, His Tag, low endotoxin (MALS verified)
CDA-H5258	Human	HEK293	Human CD8 alpha Protein, Fc Tag, low endotoxin (MALS verified)
CDA-HA2H4	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His TagStar Staining
CDA-HA2H5	Human	HEK293	Alexa Fluor™ 647-Labeled Human CD8 alpha Protein, His TagStar Staining
CDA-HA2H6	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His Tag
CDA-HA2H7	Human	HEK293	APC-Labeled Human CD8 alpha Protein, His TagStar Staining
CDA-HP2H3	Human	HEK293	PE-Labeled Human CD8 alpha Protein, His TagStar Staining

総数量13

CD8 alphaバックグランド

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

CD8 alpha分子の別称

CD8A,CD8,Leu2,MAL,p32

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
89Zr-Df-crefmirlimab	IAB-22-M2C	Phase 3 Clinical	Imaginab Inc	Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Leukoencephalopathy, Progressive Multifocal; Lymphoma; Melanoma; Multiple Sclerosis; Skin Melanoma; Solid tumours	詳細
RB-0003	RB-0003; BNT-111	Phase 2 Clinical	Biontech Se, Tron	Melanoma	詳細
CD8+ memory T cell therapy (Stanford University)		Phase 2 Clinical	Stanford University	Leukemia; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
GEN-009	GEN-009	Phase 2 Clinical	Genocea Biosciences Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck	詳細
VE-800	VE-800	Phase 2 Clinical	Vedanta Biosciences Inc	Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Neoplasm Metastasis; Stomach Neoplasms	詳細
EBViNT Cell (Eutilex)		Phase 2 Clinical	Eutilex	Lymphoma, Extranodal NK-T-Cell	詳細
ZED88082A	ZED88082A	Phase 2 Clinical	Umcg The University Medical Center Groningen	Neoplasm Metastasis; Neoplasms	詳細
AZD-6750	AZD6750; AZD-6750	Phase 2 Clinical	Astrazeneca Plc	Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cystadenocarcinoma, Serous; Melanoma; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms	詳細
AZD-9793	AZD9793; AZD-9793	Phase 2 Clinical	Astrazeneca Plc	Carcinoma, Hepatocellular; Neoplasm Metastasis; Solid tumours	詳細
AZD-5492	AZD5492	Phase 2 Clinical	Astrazeneca Plc	Arthritis, Rheumatoid; Leukemia, B-Cell; Lupus Erythematosus, Systemic; Lymphoma, B-Cell; Myositis; Neoplasms	詳細
SNA-006	68-Ga-NODAGA-SNA-006; 68Ga-NODAGA-SNA006; SNA-006	Phase 2 Clinical	Smartnuclide Biopharma	Neoplasms; Solid tumours	詳細
NY-ESO-1-specific autologous CD8+ T-cell therapy (Fred Hutchinson Cancer Research Center)		Phase 1 Clinical	Fred Hutchinson Cancer Research Center, National Cancer Institute	Liposarcoma; Sarcoma; Sarcoma, Synovial	詳細
MTX-101 (Mozart Therapeutics)	MTX-101 (Mozart Therapeutics)	Phase 1 Clinical	Mozart Therapeutics Inc	Autoimmune Diseases; Diabetes Mellitus, Type 1	詳細
[18F]GEH200521	GEH200521 (18F); GEH-200521	Phase 1 Clinical	Ge Healthcare	Solid tumours	詳細
Tcrx T cell Therapy(Second Affiliated Hospital School Of Zhejiang University School Of Medicine)		Phase 1 Clinical	Second Affiliated Hospital School Of Zhejiang University School Of Medicine	Gastroesophageal Junction Neoplasms; Stomach Neoplasms	詳細
SCRI-E2CAR_EGFRtv1	SCRI-E2CAR_EGFRtv1	Phase 1 Clinical	Umoja BioPharma Inc	Osteosarcoma	詳細
89Zr-DFO-REGN5054	89Zr-DFO-REGN5054	Phase 1 Clinical	Regeneron Pharmaceuticals Inc	Solid tumours	詳細
AGX-148	AGX-148; AGX148	Phase 1 Clinical	AgonOx Inc	Colorectal Neoplasms; Genital Neoplasms, Female; Lung Neoplasms; Melanoma; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urogenital Neoplasms	詳細