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Claudin-18.2

Claudin-18.2

Claudin-18.2 詳細

Molecule Name
Claudin-18 splice variant 2
分子の別称
Claudin-18.2,CLDN18,Claudin-18
Drug Development Progress
治験薬の数85
市販薬剤の数1
研究＆開発段階Approved
ターゲットの別称
UNQ778/PRO1572，CLDN18，Claudin 18，Surfactant Associated Protein J，Surfactant， Pulmonary Associated Protein J，Surfactant Associated 5，Claudin-18，SFTA5，SFTPJ，Claudin 18.2，CLDN18.2
バックグランド
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Claudin-18.2 製品リスト

Species
  • Human / Cynomolgus（6）
  • Human（4）
  • Mouse（2）
Tag
  • -（5）
  • His Tag & Strep Tag（4）
  • His Tag & Flag Tag（2）
  • GFP Tag（1）
Host
  • InsectCells（6）
  • HEK293（5）
  • E. coli（1）
Conjugate
  • Unconjugated（7）
  • Biotin-labeled（3）
  • GFP Fusion（1）
  • PE Labeled（1）
Grade
  • RUO（12）
Low Endotoxin
  • No（12）
MoleculeCat. No.Product Name種HostStructurePurityActivitySize&Price
Claudin-18.2
HOT
CL2-H52P7
Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRIdentity

$620.00

20ug
Claudin-18.2
HOT
CL2-M5585
Mouse Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)
Mouse
InsectCells
SDS-PAGE
ELISASPR

$845.00

20ug
Claudin-18.2
HOT
CL2-H5587
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)
Human / Cynomolgus
InsectCells
ELISASPRBLI

$1235.00

20ug
Claudin-18.2
HOTAvitag
CL2-H85D3
Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag™&Flag Tag (Detergent)
Human / Cynomolgus
InsectCells
SDS-PAGE
ELISA

$1340.00

20ug
Claudin-18.2
CL2-H51D3
Human Claudin-18.2 Full Length Protein, Flag,His Tag (Detergent)
Human
E. coli
ELISASPR

$496.00

20ug
Claudin-18.2
CL2-H5586
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc)
Human / Cynomolgus
InsectCells
ELISASPRFlow

$1440.00

20ug
Claudin-18.2
CL2-H5589
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc-pro)
Human / Cynomolgus
InsectCells
ELISASPRBLIFlow

$750.00

20ug
Claudin-18.2
CL2-H82P3
Biotinylated Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRIdentity

$620.00

20ug
Claudin-18.2
Avitag
CL2-H85D4
Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag™&Flag Tag (Nanodisc)
Human / Cynomolgus
InsectCells
ELISAFlow

$1955.00

20ug
Claudin-18.2
CL2-HF218
Fluorescent Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRFlowIdentity

$620.00

20ug
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抗体購入プラットフォーム

プロジェクトステージタイプ由来疾患領域適応症
CLDN18.2 CAR-T - 01PhaseICARNanobodySolid TumorAdvanced refractory gastrointestinal tumors
CLDN18.2 VHH - 01LeadMonoclonalNanobodySolid TumorGastric Cancer,Pancreatic cancer
プロジェクト
CLDN18.2 CAR-T - 01
ステージ
PhaseI
タイプ
CAR
由来
Nanobody
疾患領域
Solid Tumor
適応症
Advanced refractory gastrointestinal tumors
プロジェクト
CLDN18.2 VHH - 01
ステージ
Lead
タイプ
Monoclonal
由来
Nanobody
疾患領域
Solid Tumor
適応症
Gastric Cancer,Pancreatic cancer

ライセンシング

プロジェクト薬物タイプ治療分野適応症ステージエリア
Claudin18.2×CD8+ T bsAbBispecific antibodyOncology/CancerGastric cancer,Pancreatic cancer,OophoromaINDGlobal
CLDN 18.2 CAR-TCell therapyOncology/CancerGastric Cancer,Pancreatic CancerINDGlobal
Claudin18.2 mAbMonospecific antibodyOncology/CancerGastric cancerPhase IGlobal
プロジェクト
Claudin18.2×CD8+ T bsAb
薬物タイプ
Bispecific antibody
治療分野
Oncology/Cancer
適応症
Gastric cancer,Pancreatic cancer,Oophoroma
ステージ
IND
エリア
Global
プロジェクト
CLDN 18.2 CAR-T
薬物タイプ
Cell therapy
治療分野
Oncology/Cancer
適応症
Gastric Cancer,Pancreatic Cancer
ステージ
IND
エリア
Global
プロジェクト
Claudin18.2 mAb
薬物タイプ
Monospecific antibody
治療分野
Oncology/Cancer
適応症
Gastric cancer
ステージ
Phase I
エリア
Global
Resources

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市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
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