Claudin-18.2

Claudin-18.2 詳細

英語名Claudin-18 splice variant 2市販薬剤の数1
治験薬の数85ターゲットの別称UNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2,CLDN18.2
研究&開発段階Approved
英語名Claudin-18 splice variant 2
ターゲットの別称UNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2,CLDN18.2
市販薬剤の数1
治験薬の数85
研究&開発段階Approved

Claudin-18.2 製品リスト

  • 属性

    Protein (12)Cell (1)Antibody (1)

  • 製品ライブラリ

    オンライン (14)

  • 種

    Human / Cynomolgus (6)Human (5)Mouse (3)

  • タグ

    His Tag & Strep Tag (4)- (7)GFP Tag (1)His Tag & Flag Tag (2)

  • マーカー

    Unconjugated (8)- (1)GFP Fusion (1)Biotin-labeled (3)PE Labeled (1)

Claudin-18.2バックグランド

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Claudin-18.2分子の別称

Claudin-18.2,CLDN18,Claudin-18

抗体購入プラットフォーム

プロジェクトステージタイプ由来疾患領域適応症
CLDN18.2 CAR-T - 01PhaseICARNanobodySolid TumorAdvanced refractory gastrointestinal tumors
CLDN18.2 VHH - 01LeadMonoclonalNanobodySolid TumorGastric Cancer,Pancreatic cancer

ライセンシング

プロジェクト薬物タイプ治療分野適応症ステージエリア
Claudin18.2×CD8+ T bsAbBispecific antibodyOncology/CancerGastric cancer,Pancreatic cancer,OophoromaINDGlobal
CLDN 18.2 CAR-TCell therapyOncology/CancerGastric Cancer,Pancreatic CancerINDGlobal
Claudin18.2 mAbMonospecific antibodyOncology/CancerGastric cancerPhase IGlobal

治験薬に関する情報

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JS-107JS-107; JS107Phase 3 ClinicalShanghai Junshi Biosciences Co LtdAdenocarcinoma; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
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KD-182KD-182Phase 2 ClinicalNanjing Kaidi Medical Technology Co LtdCarcinoma, Pancreatic Ductal; Stomach Neoplasms
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EB-DNK102EB-DNK102Phase 2 ClinicalBeijing BiotechCarcinoma, Pancreatic Ductal
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Claudin18.2 targeting CAR-T cell therapy (Essen Biotech)Phase 2 ClinicalEssen BiotechPancreatic Neoplasms
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AZD-4360AZD4360; AZD-4360Phase 2 ClinicalAstrazeneca AbBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Gastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
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BDC-4182BD-4182; BDC-4182Phase 2 ClinicalBolt Biotherapeutics IncAdenocarcinoma; Esophageal Neoplasms; Neoplasms; Stomach Neoplasms
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LCB-02ALCB-02APhase 2 ClinicalLegochem Biosciences IncHematologic Neoplasms; Solid tumours
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PM-1032PM1032; PM-1032Phase 2 ClinicalShanghai Genechem Co LtdNeoplasms; Pancreatic Neoplasms
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SpevatamigPT-886; PT886Phase 2 ClinicalPhanes Therapeutics IncBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
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SKB-315SKB-315; SKB315; MK1200; MK-1200Phase 2 ClinicalSichuan Kelun-Biotech Biopharmaceutical Co LtdEsophageal Neoplasms; Solid tumours; Stomach Neoplasms
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ATG-022ATG-022; ATN-022Phase 2 ClinicalAntengene Corporation Co LtdGastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
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SOT-102SOT-102; SOT102; SO-N102Phase 2 ClinicalSotio Biotech AGPancreatic Neoplasms; Stomach Neoplasms
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Q-1802Q-1802Phase 2 ClinicalQure Biotechnology (Shanghai) Co LtdEsophageal Neoplasms; Gastrointestinal Neoplasms; Solid tumours
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SPX-102SPX-102Phase 1 ClinicalSparx Therapeutics IncNeoplasms
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LNF-2007LNF-2007; LNF2007Phase 1 ClinicalShandong New Time Pharmaceutical Co LtdSolid tumours
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AHT-102AHT102; AHT-102Phase 1 ClinicalGuangxi Lugang Biomedical Technology Co LtdSolid tumours
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AZD-6422AZD6422; AZD-6422Phase 1 ClinicalAstrazeneca PlcGastrointestinal Neoplasms
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GC-506GC506; GC-506Phase 1 ClinicalGracell Biotechnologies (Shanghai) Co LtdGastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
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68Ga-PMD22(Peking Union Medical College Hospital)Phase 1 ClinicalPeking Union Medical College HospitalGastrointestinal Neoplasms
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AK-132AK132; AK-132Phase 1 ClinicalNeoplasms; Solid tumours
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AHT-101AHT-101; AHT101Phase 1 ClinicalGuangxi Lugang Biomedical Technology Co LtdSolid tumours
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BA-1301BA-1301; BA1301Phase 1 ClinicalShandong Boan Biotechnology Co LtdEsophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
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詳細
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詳細
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詳細
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詳細
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詳細
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詳細
IBI-360IBI-360Phase 1 ClinicalNeoplasms; Solid tumours
詳細
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詳細
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詳細
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詳細
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詳細
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詳細
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詳細
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詳細
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詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
ZolbetuximabGC-182; iMAB-362; IMAB-362ApprovedGanymedVyloy, VYLOY, 威络益JapanStomach NeoplasmsAstellas Pharma Inc2024-03-26Adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Lymphangioma, Cystic; Pain; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
詳細
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