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DNAM-1

DNAM-1 Overview

English Name	CD226 antigen	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	DNAX accessory molecule 1，DNAM-1，T Lineage-Specific Activation Antigen 1 Antigen，PTA1，DNAX Accessory Molecule-1，Adhesion Glycoprotein，TLiSA1，DNAM1，CD226 Molecule，Platelet And T Cell Activation Antigen 1
Highest Development Stage	Preclinical

English Name	CD226 antigen
Target Synonym	DNAX accessory molecule 1，DNAM-1，T Lineage-Specific Activation Antigen 1 Antigen，PTA1，DNAX Accessory Molecule-1，Adhesion Glycoprotein，TLiSA1，DNAM1，CD226 Molecule，Platelet And T Cell Activation Antigen 1
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

DNAM-1 Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (3)Cynomolgus (1)Mouse (1)
Tag
His Tag (3)Fc Tag (1)Fc Tag & Avi Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT DN1-H5257	Human	HEK293	Human DNAM-1 / CD226 Protein, Fc Tag (MALS verified)
HOT DN1-H52H6	Human	HEK293	Human DNAM-1 / CD226 Protein, His Tag
HOT DN1-H82F9	Human	HEK293	Biotinylated Human DNAM-1 / CD226 Protein, Fc,Avitag™
HOT DN1-M52H5	Mouse	HEK293	Mouse DNAM-1 / CD226 Protein, His Tag (SPR verified)
DN1-C52H9	Cynomolgus	HEK293	Cynomolgus DNAM-1 / CD226 Protein, His Tag

Total: 5

DNAM-1 Background

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.