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ErbB3

ErbB3 詳細

英語名	Receptor tyrosine-protein kinase erbB-3	市販薬剤の数	2
治験薬の数	31	ターゲットの別称	EC:2.7.10.1，FERLK，EC 2.7.10，Proto-oncogene-like protein c-ErbB-3，HER3，ERBB3，Erb-B2 Receptor Tyrosine Kinase 3，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3，Tyrosine Kinase-Type Cell Surface Receptor HER3，Human Epidermal Growth Factor Receptor 3，Lethal Congenital Contracture Syndrome 2，Receptor Tyrosine-Protein Kinase ErbB-3，EC 2.7.10.1，P180-ErbB3，P45-SErbB3，P85-SErbB3，MDA-BF-1，C-ErbB-3，C-ErbB3，ErbB3-S，ErbB-3，LCCS2，Receptor， ErbB-3
研究＆開発段階	Approved

英語名	Receptor tyrosine-protein kinase erbB-3
ターゲットの別称	EC:2.7.10.1，FERLK，EC 2.7.10，Proto-oncogene-like protein c-ErbB-3，HER3，ERBB3，Erb-B2 Receptor Tyrosine Kinase 3，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3，Tyrosine Kinase-Type Cell Surface Receptor HER3，Human Epidermal Growth Factor Receptor 3，Lethal Congenital Contracture Syndrome 2，Receptor Tyrosine-Protein Kinase ErbB-3，EC 2.7.10.1，P180-ErbB3，P45-SErbB3，P85-SErbB3，MDA-BF-1，C-ErbB-3，C-ErbB3，ErbB3-S，ErbB-3，LCCS2，Receptor， ErbB-3
市販薬剤の数	2
治験薬の数	31
研究＆開発段階	Approved

ErbB3 製品リスト

属性
Protein (8)Cell (1)
製品ライブラリ
オンライン (9)
種
Human (7)Mouse (1)Cynomolgus/Rhesus macaque (1)
タグ
His Tag (4)Fc Tag (1)Strep Tag (1)Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)- (1)
マーカー
Unconjugated (6)FITC Labeled (1)Biotin-labeled (1)- (1)

製品番号	種	発現システム	製品説明
HOT ER3-H5223	Human	HEK293	Human ErbB3 / Her3 Protein, His Tag (MALS verified)
HOT ER3-H5257	Human	HEK293	Human ErbB3 / Her3 Protein, Mouse IgG2a Fc Tag (MALS verified)
HOT ER3-H5259	Human	HEK293	Human ErbB3 / Her3 Protein, Fc Tag (MALS verified)
HOT ER3-H82E6	Human	HEK293	Biotinylated Human ErbB3 / Her3 Protein, His,Avitag™ (MALS verified)
HOT ER3-M52H5	Mouse	HEK293	Mouse ErbB3 / Her3 Protein, His Tag (MALS verified)
CHEK-ATP149	Human	HEK293	HEK293/Human ErbB3 Stable Cell Line
ER3-H5288	Human	HEK293	Human ErbB3 / Her3 Protein, Twin-Strep Tag (MALS verified)
ER3-HF2H5	Human	HEK293	FITC-Labeled Human ErbB3 / Her3 Protein, His Tag
ER3-C52H3	Cynomolgus/Rhesus macaque	HEK293	Cynomolgus/Rhesus macaque ErbB3 / Her3 Protein, His Tag (MALS verified)

総数量9

ErbB3バックグランド

ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

ErbB3分子の別称

ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Izalontamab	SI-B001; SI-1X6.4	Phase 3 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Neoplasms, Glandular and Epithelial; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms	詳細
JSKN-016	JSKN-016; JSKN016	Phase 3 Clinical	Jiangsu Alphamab Biopharmaceuticals Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastroesophageal Junction Neoplasms; Metastatic breast cancer; Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	詳細
YL-202	YL-202; BNT326	Phase 3 Clinical	MediLink Therapeutics Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	詳細
SHR-A2009	SHR-A2009	Phase 3 Clinical	Suzhou Suncadia Biopharmaceuticals Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Solid tumours; Triple Negative Breast Neoplasms	詳細
Patritumab Deruxtecan	U3-1402; U3-1402a; MK-1022	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Metastatic breast cancer; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
Nezutatug	HMBD-001	Phase 2 Clinical	Hummingbird Bioscience	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
Sapitinib	AZD-8931	Phase 2 Clinical	Astrazeneca Plc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms	詳細
Allitinib Tosylate	AST-6; ALS-1306; AST-1306	Phase 2 Clinical	Shanghai Allist Pharmaceutical Technology Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung	詳細
HMBD-501	ENV-501; HMBD-501; ENV-ONC-501	Phase 2 Clinical	Hummingbird Bioscience	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Skin Melanoma	詳細
JS-212	JS212; JS-212	Phase 2 Clinical	Shanghai Junshi Biosciences Co Ltd	Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Solid tumours	詳細
DB-1418	AVZO-1418; DB-1418	Phase 2 Clinical	Duality Biologics (Suzhou) Co Ltd	Lung Neoplasms; Neoplasms, Glandular and Epithelial; Solid tumours	詳細
89Zr-Patritumab deruxtecan		Phase 2 Clinical	Daiichi Sankyo Co Ltd, Daiichi Sankyo Inc, The Netherlands Cancer Institute	Carcinoma, Non-Small-Cell Lung	詳細
IBI-133	IBI133; IBI-133	Phase 2 Clinical		Solid tumours	詳細
DB-1310	DB-1310	Phase 2 Clinical	Duality Biologics (Shanghai) Co Ltd, Duality Biologics (Suzhou) Co Ltd	Neoplasm Metastasis; Solid tumours	詳細
SIBP-03	SIBP-03	Phase 2 Clinical	Shanghai Institute of Biological Products Co Ltd	Neoplasms; Squamous Cell Carcinoma of Head and Neck	詳細
JK-07 (SalubrisBio)	JK07; SAL007; SAL-007	Phase 2 Clinical	Salubris Biotherapeutics Inc	Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Pulmonary Arterial Hypertension	詳細
Recombinat humanized HER3-targeting antibody		Phase 2 Clinical	Shanghai Institute of Biological Products Co Ltd	Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
Elgemtumab	NOV-6; LJM-716	Phase 1 Clinical	Morphosys Ag, Novartis Pharma Ag	Breast Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	詳細
MP-0274	DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274	Phase 1 Clinical	Molecular Partners Ag	Neoplasms	詳細
AV-203	AV-203; CAN-017	Phase 1 Clinical	Aveo	Neoplasms; Solid tumours	詳細
HDM-2024	HDM2024; HDM-2024	Phase 1 Clinical	Hangzhou Zhongmei Huadong Pharmaceutical Co Ltd	Solid tumours	詳細
KHN-922	KHN-922	Phase 1 Clinical	Chengdu Kanghong Pharmaceutical Group Co Ltd	Neoplasms; Solid tumours	詳細
Sirotinib Maleate	XZP-5491	Phase 1 Clinical	Shandong Xuanzhu Pharmaceutical Technology Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Stomach Neoplasms	詳細
PM1300	PM-1300; PM1300	Phase 1 Clinical		Neoplasms	詳細
AK-138-D-1	AK138D1; AK-138-D-1	Phase 1 Clinical		Neoplasms; Solid tumours	詳細
BL-B16D1	BLB16D1; BL-B16D1	Phase 1 Clinical	Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
SYS-6023	SYS-6023; SYS6023	Phase 1 Clinical	Jushi Biopharmaceutical Co Ltd	Breast Neoplasms; Metastatic breast cancer; Solid tumours	詳細
AMT-562	AMT-562	Phase 1 Clinical	Multitude Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Solid tumours; Stomach Neoplasms	詳細
SIBP-A13	SIBP-A13	Phase 1 Clinical	Shanghai Institute of Biological Products Co Ltd	Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Metastatic breast cancer; Solid tumours	詳細
Recombinant human ErbB3 fragment vaccine (Zensun)	rhErbB3-f	Phase 1 Clinical	Zensun (Shanghai) Sci&Tech Co Ltd	Neoplasms	詳細
DM-002	DM-002; DM002 (Danma)	Phase 1 Clinical	Danma (Suzhou) Biomedical Technology Co Ltd	Colorectal Neoplasms; Endometrial Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Osimertinib Mesylate	AZD-9291; RDL94R2A16; AZD-9291 Mesylate; AZD9291	Approved	Astrazeneca Plc	泰瑞沙, Tagrisso	United States	Carcinoma, Non-Small-Cell Lung	Astrazeneca Pharmaceutical Co Ltd	2015-11-13	Adenocarcinoma; Adenocarcinoma of Lung; Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphoma; Melanoma; Meningeal Neoplasms; Multiple Myeloma; Neoplasm, Residual; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms	詳細
Zenocutuzumab	MCLA-128	Approved	Merus Nv	Bizengri	United States	Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung	Merus Nv	2024-12-04	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours	詳細