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Fc epsilon RI alpha

Fc epsilon RI alpha Overview

English Name	IgE Fc receptor, alpha-subunit	Approved Drugs	1
Drugs in Clinical Trials	1	Target Synonym	Fc Fragment Of IgE， High Affinity I， Receptor For; Alpha Polypeptide，FCE1A，IgE Fc receptor subunit alpha，Fc-epsilon RI-alpha，FCER1A，Fc Fragment Of IgE Receptor Ia，Fc Fragment Of IgE， High Affinity I， Receptor For，Alpha Polypeptide，Fc Epsilon Receptor Ia，FcERI，Immunoglobulin E Receptor， High-Affinity， Of Mast Cells， Alpha Polypeptide，High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit，High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha，Fc IgE Receptor， Alpha Polypeptide，Fc Epsilon RI Alpha-Chain，FCER1
Highest Development Stage	Approved

English Name	IgE Fc receptor, alpha-subunit
Target Synonym	Fc Fragment Of IgE， High Affinity I， Receptor For; Alpha Polypeptide，FCE1A，IgE Fc receptor subunit alpha，Fc-epsilon RI-alpha，FCER1A，Fc Fragment Of IgE Receptor Ia，Fc Fragment Of IgE， High Affinity I， Receptor For，Alpha Polypeptide，Fc Epsilon Receptor Ia，FcERI，Immunoglobulin E Receptor， High-Affinity， Of Mast Cells， Alpha Polypeptide，High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit，High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha，Fc IgE Receptor， Alpha Polypeptide，Fc Epsilon RI Alpha-Chain，FCER1
Approved Drugs	1
Drugs in Clinical Trials	1
Highest Development Stage	Approved

Fc epsilon RI alpha Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (3)Cynomolgus (2)Mouse (1)
Tag
His Tag (2)Fc Tag (3)His Tag & Avi Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT FCA-H5228	Human	HEK293	Human Fc epsilon RI alpha Protein, His Tag, low endotoxin (MALS verified)
HOT FCA-H5259	Human	HEK293	Human Fc epsilon RI alpha Protein, Fc Tag (MALS & BLI verified)
HOT FCA-H82E3	Human	HEK293	Biotinylated Human Fc epsilon RI alpha Protein, His,Avitag™ (MALS verified)
HOT FCA-C52H9	Cynomolgus	HEK293	Cynomolgus Fc epsilon RI alpha Protein, His Tag (SPR verified)
FCA-M5253	Mouse	HEK293	Mouse Fc epsilon RI alpha Protein, Fc Tag
FCA-C5255	Cynomolgus	HEK293	Cynomolgus Fc epsilon RI alpha Protein, Fc Tag (BLI verified)

Total: 6

Fc epsilon RI alpha Background

Fc epsilon RI alpha (FcεRIα) is the α-chain of the high-affinity IgE receptor (FcεRI), a critical mediator of type I hypersensitivity. As a transmembrane glycoprotein in the immunoglobulin superfamily, its extracellular domain specifically binds the Fc region of IgE. Mainly expressed on mast cells and basophils, FcεRIα cross-linking (by IgE-allergen complexes) triggers cell degranulation, releasing histamine and proinflammatory mediators—driving allergies, asthma, and anaphylaxis. It also participates in immune surveillance. Owing to its central role in allergic responses, FcεRIα is a key therapeutic target for anti-allergy agents.

Fc epsilon RI alpha Synonyms

FCER1A,FCE1A,FcERI

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Lesigercept	YH-35324; GI-301	Phase 2 Clinical	Yuhan Corp	Chronic Urticaria; Hypersensitivity; Immune System Diseases; Urinary Tract Infections; Urticaria	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indication	Clinical Trial
Benzylpenicilloyl Polylysine		Approved	Allerquest Llc	Pre-pen	United States	Anaphylaxis; Diagnostic agents	Allerquest Inc	1974-07-25	Anaphylaxis; Diagnostic agents	Details