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Fc epsilon RI alpha

Fc epsilon RI alpha Overview

English Name	IgE Fc receptor, alpha-subunit	Approved Drugs	1
Drugs in Clinical Trials	1	Target Synonym	Fc Fragment Of IgE， High Affinity I， Receptor For; Alpha Polypeptide，FCE1A，IgE Fc receptor subunit alpha，Fc-epsilon RI-alpha，FCER1A，Fc Fragment Of IgE Receptor Ia，Fc Fragment Of IgE， High Affinity I， Receptor For，Alpha Polypeptide，Fc Epsilon Receptor Ia，FcERI，Immunoglobulin E Receptor， High-Affinity， Of Mast Cells， Alpha Polypeptide，High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit，High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha，Fc IgE Receptor， Alpha Polypeptide，Fc Epsilon RI Alpha-Chain，FCER1
Highest Development Stage	Approved

English Name	IgE Fc receptor, alpha-subunit
Target Synonym	Fc Fragment Of IgE， High Affinity I， Receptor For; Alpha Polypeptide，FCE1A，IgE Fc receptor subunit alpha，Fc-epsilon RI-alpha，FCER1A，Fc Fragment Of IgE Receptor Ia，Fc Fragment Of IgE， High Affinity I， Receptor For，Alpha Polypeptide，Fc Epsilon Receptor Ia，FcERI，Immunoglobulin E Receptor， High-Affinity， Of Mast Cells， Alpha Polypeptide，High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit，High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha，Fc IgE Receptor， Alpha Polypeptide，Fc Epsilon RI Alpha-Chain，FCER1
Approved Drugs	1
Drugs in Clinical Trials	1
Highest Development Stage	Approved

Fc epsilon RI alpha Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (3)Cynomolgus (2)Mouse (1)
Tag
His Tag (2)Fc Tag (3)His Tag & Avi Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT FCA-H5228	Human	HEK293	Human Fc epsilon RI alpha Protein, His Tag, low endotoxin (MALS verified)
HOT FCA-H5259	Human	HEK293	Human Fc epsilon RI alpha Protein, Fc Tag (MALS & BLI verified)
HOT FCA-H82E3	Human	HEK293	Biotinylated Human Fc epsilon RI alpha Protein, His,Avitag™ (MALS verified)
HOT FCA-C52H9	Cynomolgus	HEK293	Cynomolgus Fc epsilon RI alpha Protein, His Tag (SPR verified)
FCA-M5253	Mouse	HEK293	Mouse Fc epsilon RI alpha Protein, Fc Tag
FCA-C5255	Cynomolgus	HEK293	Cynomolgus Fc epsilon RI alpha Protein, Fc Tag (BLI verified)

Total: 6

Fc epsilon RI alpha Background

High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.

Fc epsilon RI alpha Synonyms

FCER1A,FCE1A,FcERI

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Lesigercept	YH-35324; GI-301	Phase 2 Clinical	Yuhan Corp	Chronic Urticaria; Hypersensitivity; Immune System Diseases; Urinary Tract Infections; Urticaria	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Benzylpenicilloyl Polylysine		Approved	Allerquest Llc	Pre-pen	United States	Anaphylaxis; Diagnostic agents	Allerquest Inc	1974-07-25	Anaphylaxis; Diagnostic agents	Details