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Klotho beta

Klotho beta 詳細

英語名	Klotho beta	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
研究＆開発段階	Phase 2 Clinical

英語名	Klotho beta
ターゲットの別称	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

Klotho beta 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Human (2)Rhesus macaque (1)
タグ
His Tag (7)
マーカー
Unconjugated (5)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT KLB-H52H4	Human	HEK293	Human Klotho beta / KLB Protein, His Tag
HOT KLB-M52H7	Mouse	HEK293	Mouse Klotho beta / KLB Protein, His Tag
HOT KLB-R52H8	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag
KLB-H82H3	Human	HEK293	Biotinylated Human Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)
KLB-M52H3	Mouse	HEK293	Biotinylated Mouse Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) (HPLC verified)
KLB-R52H6	Rat	HEK293	Rat Klotho beta / KLB Protein, His Tag
KLB-R82H3	Rhesus macaque	HEK293	Biotinylated Rhesus macaque Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)

総数量7

Klotho betaバックグランド

KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.

Klotho beta分子の別称

betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
NGM-313	NGM-313; MK-3655	Phase 2 Clinical	NGM Biopharmaceuticals Inc	Hepatitis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	詳細
JMT-202	JMT202; JMT-202	Phase 2 Clinical	Shanghai Jmt-Bio Inc	Hypertriglyceridemia	詳細
DR-10624	DR-10624; DR10624	Phase 2 Clinical	Zhejiang Doer Biologics Corp	Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight	詳細