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LGR5

LGR5

LGR5 詳細

Molecule Name
Leucine-rich repeat-containing G-protein coupled receptor 5
分子の別称
LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5
Drug Development Progress
治験薬の数2
市販薬剤の数0
研究＆開発段階Phase 2 Clinical
ターゲットの別称
FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
バックグランド
LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5 製品リスト

Species
  • Human（3）
  • Cynomolgus（1）
  • Mouse（1）
Tag
  • Fc Tag（2）
  • His Tag（2）
  • His Tag & Avi Tag（1）
Host
  • HEK293（5）
Conjugate
  • Unconjugated（4）
  • Biotin-labeled（1）
Grade
  • RUO（5）
Low Endotoxin
  • Yes（1）
  • No（4）
MoleculeCat. No.Product Name種HostStructurePurityActivitySize&Price
LGR5
LG5-C52H7
Cynomolgus LGR5 / GPR49 protein, His Tag
Cynomolgus
HEK293
SDS-PAGE
ELISA

$360.00

100ug
LGR5
LG5-H5253
Human LGR5 / GPR49 protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISA

$380.00

100ug
LGR5
LG5-H52H3
Human LGR5 / GPR49 Protein, His Tag, low endotoxin (Mass Spec verified)
Human
HEK293
SDS-PAGE
ELISASPR

$435.00

100ug
LGR5
Avitag
LG5-H82E4
Biotinylated Human LGR5 / GPR49 (22-561) Protein, His,Avitag™
Human
HEK293
SDS-PAGE
ELISA

$360.00

25ug
LGR5
LG5-M5253
Mouse LGR5 / GPR49 Protein, Fc Tag
Mouse
HEK293
SDS-PAGE
ELISA

$360.00

100ug
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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
PetosemtamabMCLA-158Phase 2 ClinicalMerus Nv
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms
詳細
CNA-3103CNA-3103Phase 2 ClinicalCarina Biotech Pty Ltd
Colorectal Neoplasms
詳細
Customer Reviews