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LGR5

LGR5 詳細

英語名	Leucine-rich repeat-containing G-protein coupled receptor 5	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
研究＆開発段階	Phase 2 Clinical

英語名	Leucine-rich repeat-containing G-protein coupled receptor 5
ターゲットの別称	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

LGR5 製品リスト

属性
Protein (4)Cell (1)
製品ライブラリ
オンライン (5)
種
Human (4)Cynomolgus (1)
タグ
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (1)
マーカー
Unconjugated (3)Biotin-labeled (1)- (1)

製品番号	種	発現システム	製品説明
CHEK-ATP327	Human	HEK293	HEK293/Human LGR5 Stable Cell Line
LG5-H5253	Human	HEK293	Human LGR5 / GPR49 protein, Fc Tag
LG5-H52H3	Human	HEK293	Human LGR5 / GPR49 Protein, His Tag, low endotoxin
LG5-H82E4	Human	HEK293	Biotinylated Human LGR5 / GPR49 (22-561) Protein, His,Avitag™
LG5-C52H7	Cynomolgus	HEK293	Cynomolgus LGR5 / GPR49 protein, His Tag

総数量5

LGR5バックグランド

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5分子の別称

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Petosemtamab	MCLA-158	Phase 2 Clinical	Merus Nv	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	詳細
CNA-3103	CNA-3103	Phase 2 Clinical	Carina Biotech Pty Ltd	Colorectal Neoplasms	詳細