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MAG / Siglec-4a

MAG / Siglec-4a 詳細

英語名	Myelin-associated glycoprotein	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	MAG，Siglec-4a，GMA，Sialic Acid Binding Ig-Like Lectin 4A，Myelin-Associated Glycoprotein，SIGLEC4A，S-MAG，SPG75，Myelin Associated Glycoprotein，Sialic Acid-Binding Immunoglobulin-Like Lectin 4A
研究＆開発段階	Phase 2 Clinical

英語名	Myelin-associated glycoprotein
ターゲットの別称	MAG，Siglec-4a，GMA，Sialic Acid Binding Ig-Like Lectin 4A，Myelin-Associated Glycoprotein，SIGLEC4A，S-MAG，SPG75，Myelin Associated Glycoprotein，Sialic Acid-Binding Immunoglobulin-Like Lectin 4A
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

MAG / Siglec-4a 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (1)Fc Tag (1)His Tag & Avi Tag (2)
マーカー
Unconjugated (2)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT MAG-H5254	Human	HEK293	Human MAG / Siglec-4a Protein, Fc Tag
HOT MAG-H52H8	Human	HEK293	Human MAG / Siglec-4a Protein, His Tag
HOT MAG-H82E9	Human	HEK293	Biotinylated Human MAG / Siglec-4a Protein, His,Avitag™
MAG-M82E9	Mouse	HEK293	Biotinylated Mouse MAG / Siglec-4a Protein, His,Avitag™ (MALS verified)

総数量4

MAG / Siglec-4aバックグランド

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.