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MCAM

MCAM 詳細

英語名	Melanoma cell adhesion molecule	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
研究＆開発段階	Phase 2 Clinical

英語名	Melanoma cell adhesion molecule
ターゲットの別称	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

MCAM 製品リスト

属性
Protein (3)Cell (1)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (2)- (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (2)- (1)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
CD6-H5229	Human	HEK293	Human MCAM / CD146 Protein, His Tag
CHEK-ATP195	Human	HEK293	HEK293/Human MCAM Stable Cell Line
MCM-H82E3	Human	HEK293	Biotinylated Human MCAM / CD146 Protein, His,Avitag™ (MALS verified)
MCM-M52H3	Mouse	HEK293	Mouse MCAM / CD146 Protein, His Tag

総数量4

MCAMバックグランド

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM分子の別称

MCAM,CD146,MUC18

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
CD146 targeting CAR-T cell therapy (Essen Biotech)		Phase 2 Clinical	Essen Biotech	Carcinoma, Ovarian Epithelial; Osteosarcoma; Ovarian Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial	詳細
AMT-253(Multitude)	AMT-253; AMT-253 ADC	Phase 2 Clinical	Multitude Therapeutics Inc	Melanoma; Solid tumours	詳細