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MICA

MICA 詳細

英語名	MHC class I polypeptide-related sequence A	市販薬剤の数	0
治験薬の数	4	ターゲットの別称
研究＆開発段階	Phase 1 Clinical

英語名	MHC class I polypeptide-related sequence A
ターゲットの別称
市販薬剤の数	0
治験薬の数	4
研究＆開発段階	Phase 1 Clinical

MICA 製品リスト

属性
Protein (10)
製品ライブラリ
オンライン (10)
種
Human (9)Cynomolgus (1)
タグ
His Tag (3)Fc Tag (2)His Tag & Avi Tag (2)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Human IgG4 Fc Tag (1)
マーカー
Unconjugated (7)Biotin-labeled (3)

製品番号	種	発現システム	製品説明
HOT MIA-H5221	Human	HEK293	Human MICA Protein, His Tag, low endotoxin (MALS verified)
HOT MIA-H5253	Human	HEK293	Human MICA Protein, Fc Tag
HOT MIA-H52H7	Human	HEK293	Human MICA (24-202) Protein, His Tag (MALS verified)
HOT MIA-H82E4	Human	HEK293	Biotinylated Human MICA (201-309) Protein, His,Avitag™ (MALS verified)
HOT MIA-H82E6	Human	HEK293	Biotinylated Human MICA Protein, His,Avitag™ (MALS verified)
MIA-H5254	Human	HEK293	Human MICA (24-309) Protein, Fc Tag (MALS verified)
MIA-H5255	Human	HEK293	Human MICA (24-202) Protein, Mouse IgG2a Fc Tag (MALS verified)
MIA-H5259	Human	HEK293	Human MICA Protein, IgG4 Fc Tag
MIA-H82F6	Human	HEK293	Biotinylated Human MICA Protein, Fc,Avitag™ (MALS verified)
MIA-C52H5	Cynomolgus	HEK293	Cynomolgus MICA Protein, His Tag (HPLC verified)

総数量10

MICAバックグランド

MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Isuventatug	CLN-619	Phase 1 Clinical	Cullinan MICA Corp	Carcinoma, Non-Small-Cell Lung; Multiple Myeloma; Solid tumours	詳細
FT-536	FT-536	Phase 1 Clinical	Fate Therapeutics Inc	Abdominal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Solid tumours	詳細
FT-836	FT-836; FT836	Phase 1 Clinical	Fate Therapeutics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck	詳細
DM-919	DM-919; DM919	Phase 1 Clinical	D2M Biotherapeutics Inc	Neoplasms; Solid tumours	詳細