MICA 詳細
Molecule Name
MHC class I polypeptide-related sequence A
Drug Development Progress
治験薬の数4
市販薬剤の数0
研究＆開発段階Phase 1 Clinical
ターゲットの別称
バックグランド
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
MICA 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Isuventatug | CLN-619 | Phase 1 Clinical | Cullinan MICA Corp | Carcinoma, Non-Small-Cell Lung; Multiple Myeloma; Solid tumours | 詳細 |
| FT-536 | FT-536 | Phase 1 Clinical | Fate Therapeutics Inc | Abdominal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Solid tumours | 詳細 |
| FT-836 | FT-836; FT836 | Phase 1 Clinical | Fate Therapeutics Inc | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck | 詳細 |
| DM-919 | DM-919; DM919 | Phase 1 Clinical | D2M Biotherapeutics Inc | Neoplasms; Solid tumours | 詳細 |