Select Language

MMP-3

MMP-3 Overview

English Name	Matrix metalloproteinase 3	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	CHDS6，STR1，STMY，Matrix Metalloproteinase 3，Matrix metalloproteinase-3，MMP-3，SL-1，STMY1，MMP3，Matrix Metalloproteinase 3 (Stromelysin 1， Progelatinase)，Transin-1，Proteoglycanase，Stromelysin-1，Stromelysin 1，EC 3.4.24.17，EC:3.4.24.17，EC 3.4.24，Matrix Metallopeptidase 3
Highest Development Stage	Preclinical

English Name	Matrix metalloproteinase 3
Target Synonym	CHDS6，STR1，STMY，Matrix Metalloproteinase 3，Matrix metalloproteinase-3，MMP-3，SL-1，STMY1，MMP3，Matrix Metalloproteinase 3 (Stromelysin 1， Progelatinase)，Transin-1，Proteoglycanase，Stromelysin-1，Stromelysin 1，EC 3.4.24.17，EC:3.4.24.17，EC 3.4.24，Matrix Metallopeptidase 3
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

MMP-3 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
MM3-H52H3	Human	HEK293	Human MMP-3 Protein, His Tag (Pro-form, MALS verified)

Total: 1

MMP-3 Background

Matrix metalloproteinase 3 (MMP-3), also known as stromelysin 1 and progelatinase, is encoded by the MMP3 gene. The expression of MMP3 is mainly regulated at the transcriptional level, where gene promoters respond to a variety of stimuli including growth factors, cytokines, carcinogens and proto-oncogene products. MMP-3 degrade II, III, IV, IX and X collagen, proteoglycan, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7 and MMP-9, so MMP-3 plays a key role in connective tissue remodeling. This enzyme is involved in wound repair, atherosclerotic progression, and tumor initiation. Studies of MMP-3 wild type and gene knockout in mice have shown that MMP-3 increases the permeability of the blood-brain barrier after traumatic injury. Nuclear MMP-3 works as a transcription factor and protease.