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Mucin-1

Mucin-1 詳細

英語名	Mucin-1	市販薬剤の数	0
治験薬の数	28	ターゲットの別称	PEM，Medullary Cystic Kidney Disease 1 (Autosomal Dominant)，Tumor Associated Epithelial Mucin，CD227 Antigen，H23 Antigen，MUC-1/SEC，ADMCKD1，Cancer antigen 15-3，Tumor-associated mucin，MUC1-alpha，MUC1-beta，MUC-1/X，MUC1/ZD，Mucin-1，ADMCKD，MCKD1，MAM6，MCKD，MCD，Polymorphic epithelial mucin，PUM，MUC1-NT，Episialin，CD227，MUC1-CT，MUC1，Mucin 1， Cell Surface Associated，Tumor-Associated Epithelial Membrane Antigen，Peanut-Reactive Urinary Mucin，Carcinoma-Associated Mucin，Krebs Von Den Lungen-6，CA 15-3，H23AG，MUC-1，KL-6，PEMT，EMA，Breast carcinoma-associated antigen DF3，Mucin 1， Transmembrane
研究＆開発段階	Phase 2 Clinical

英語名	Mucin-1
ターゲットの別称	PEM，Medullary Cystic Kidney Disease 1 (Autosomal Dominant)，Tumor Associated Epithelial Mucin，CD227 Antigen，H23 Antigen，MUC-1/SEC，ADMCKD1，Cancer antigen 15-3，Tumor-associated mucin，MUC1-alpha，MUC1-beta，MUC-1/X，MUC1/ZD，Mucin-1，ADMCKD，MCKD1，MAM6，MCKD，MCD，Polymorphic epithelial mucin，PUM，MUC1-NT，Episialin，CD227，MUC1-CT，MUC1，Mucin 1， Cell Surface Associated，Tumor-Associated Epithelial Membrane Antigen，Peanut-Reactive Urinary Mucin，Carcinoma-Associated Mucin，Krebs Von Den Lungen-6，CA 15-3，H23AG，MUC-1，KL-6，PEMT，EMA，Breast carcinoma-associated antigen DF3，Mucin 1， Transmembrane
市販薬剤の数	0
治験薬の数	28
研究＆開発段階	Phase 2 Clinical

Mucin-1 製品リスト

属性
Protein (19)Antibody (1)Kits (1)
製品ライブラリ
オンライン (21)
種
Human (13)Cynomolgus (5)Mouse (3)
タグ
Fc Tag (7)Llama IgG Fc Tag (1)His Tag (6)His Tag & Avi Tag (3)Mouse IgG Fc Tag (2)- (2)
マーカー
Unconjugated (16)Biotin-labeled (3)APC Labeled (1)- (1)

製品番号	種	発現システム	製品説明
HOT MU1-H52H5	Human	HEK293	Human Mucin-1 / MUC-1 (1036-1155) Protein, His Tag
HOT MU1-H52H9	Human	HEK293	Human Mucin-1 / MUC-1 (890-1158) Protein, His Tag, low endotoxin (MALS verified)
HOT MU1-H82E5	Human	HEK293	Biotinylated Human Mucin-1 (890-1158) Protein, His,Avitag™ (MALS verified)
CEA-B055	Human	-	Human MUCIN 1/MUC1 ELISA Kit
MU1-H5153	Human	E. coli	Human Mucin-1 / MUC-1 (116-173) Protein, Fc Tag
MU1-H5252	Human	HEK293	Human Mucin-1 / MUC-1 Protein, Fc Tag, low endotoxin
MU1-H5254	Human	HEK293	Human Mucin-1 / MUC-1 (24-380) Protein, Fc Tag
MU1-H5255	Human	HEK293	Human Mucin-1 / MUC-1 Protein, Llama IgG2b Fc Tag, low endotoxin
MU1-H5256	Human	HEK293	Human Mucin-1 / MUC-1 (116-173) Protein, Fc Tag
MU1-H5258	Human	HEK293	Human Mucin-1 / MUC-1 (890-1158) Protein, Fc Tag (MALS verified)

総数量21

Mucin-1バックグランド

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Mucin-1分子の別称

Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Cancer vaccine (BN ImmunoTherapeutics/National Cancer Institute)	CVAC-301; CV-301	Phase 2 Clinical	Therion Biologics	Adenocarcinoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Cystadenocarcinoma; Intestinal Neoplasms; Melanoma; Neoplasm Metastasis; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Urinary Bladder Neoplasms	詳細
PD-1 Knockout Anti-MUC1 CAR-T Cells (Guangzhou Anjie Biomedical)	AJMUC1	Phase 2 Clinical	Guangzhou Anjie Biomedical Technology	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Lung Neoplasms; Prostatic Neoplasms	詳細
Anti-MUC1 monoclonal antibody (OncoQuest)	AR20.5; mAb-AR20.5; Anti-MUC1 AR20.5	Phase 2 Clinical	Altarex	Pancreatic Neoplasms	詳細
GO-2032c	GO-203-2C	Phase 2 Clinical	Dana-Farber Cancer Institute, Genus Oncology Llc	Leukemia, Myeloid, Acute; Multiple Myeloma; Solid tumours	詳細
MUC1-Poly-ICLC	MUC1-poly-ICLC	Phase 2 Clinical	University Of Pittsburgh	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma	詳細
EB-DT-CAR-NK	EB-DT-CAR-NK	Phase 2 Clinical	Beijing Biotech	Breast Neoplasms; Triple Negative Breast Neoplasms	詳細
EB-DNK102	EB-DNK102	Phase 2 Clinical	Beijing Biotech	Carcinoma, Pancreatic Ductal	詳細
EB-DNK101	EB-DNK101	Phase 2 Clinical	Beijing Biotech	Carcinoma, Pancreatic Ductal	詳細
DS-3939	DS-3939; DS-3939a; GT-00A	Phase 2 Clinical	Daiichi Sankyo Inc	Solid tumours	詳細
BM7PE		Phase 2 Clinical	Oslo University Hospital	Colorectal Neoplasms	詳細
Anti-MUC1 CAR T-cell therapy (Guangzhou Anjie Biomedical Technology/University of Technology Sydney)		Phase 2 Clinical	Guangzhou Anjie Biomedical Technology, The First Affiliated Hospital Of Guangdong Pharmaceutical University, University of Sydney	Carcinoma, Non-Small-Cell Lung	詳細
huMNC2-CAR44	huMNC2-CAR44	Phase 1 Clinical	Minerva Biotechnologies Co	Metastatic breast cancer	詳細
ICTCAR-052	ICTCAR-052	Phase 1 Clinical	Innovative Cellular Therapeutics Co Ltd	Breast Neoplasms; Lung Neoplasms; Pancreatic Neoplasms	詳細
recombinant adenovirus vector vaccine targeting MUC1 (MicroVax)		Phase 1 Clinical	Microvax Llc	Neoplasms	詳細
P-MUC1C-ALLO1	P-MUC1C-ALLO1; P-MUC1C-101	Phase 1 Clinical	Poseida Therapeutics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	詳細
NEOK-002	ABL209; ABL-209; NEOK002; NEOK-002	Phase 1 Clinical	Abl Bio Inc, Biocytogen Pharmaceuticals (Beijing) Co Ltd	Neoplasms; Solid tumours	詳細
M-0324	M-0324; M0324	Phase 1 Clinical	Merck KGaA, Darmstadt, Germany	Neoplasms; Solid tumours	詳細
YB-01(Yuanben (Zhuhai Hengqin) Biotech)	YB01; YB-01	Phase 1 Clinical	Yuanben (Zhuhai Hengqin) Biotechnology Co Ltd	Arthritis, Rheumatoid; Solid tumours	詳細
SBO-154	SBO-154	Phase 1 Clinical	Sun Pharmaceutical Advanced Research Co Ltd	Breast Neoplasms; Head and Neck Neoplasms; Pancreatic Neoplasms; Solid tumours	詳細
ICTCAR-053	ICTCAR-053	Phase 1 Clinical	Innovative Cellular Therapeutics Co Ltd	Pancreatic Neoplasms	詳細
BGB-B3227	BGB-B3227	Phase 1 Clinical	BeOne Medicines (Beijing) Co Ltd	Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	詳細
MUC1-peptide-DC-CTL (Beijing Doing Biomedical)		Phase 1 Clinical	Beijing Doing Biomedical Co Ltd	Stomach Neoplasms	詳細
MUC1-gene-DC-CTL (Beijing Doing Biomedical)		Phase 1 Clinical	Beijing Doing Biomedical Co Ltd	Stomach Neoplasms	詳細
DM-002	DM-002; DM002 (Danma)	Phase 1 Clinical	Danma (Suzhou) Biomedical Technology Co Ltd	Colorectal Neoplasms; Endometrial Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours	詳細
Recombinant HSP-MUC1 fusion protein (Newsummit)		Phase 1 Clinical	Shanghai Xinshengyuan Biological Medicine Co Ltd	Breast Neoplasms	詳細
DXC-005	DXC-005	Phase 1 Clinical	Hangzhou Dac Biotech Company Ltd	Colorectal Neoplasms; Pancreatic Neoplasms; Solid tumours	詳細
M-1231	M-1231	Phase 1 Clinical	Emd Serono Research & Development Institute Inc, Merck Serono	Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Solid tumours	詳細
ICTCAR-046	ICTCAR-046	Clinical	Innovative Cellular Therapeutics Co Ltd	Pancreatic Neoplasms	詳細