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Papain-like Protease

Papain-like Protease

Papain-like Protease 詳細

Molecule Name
SARS-CoV-2-3C-like-proteinase
分子の別称
Papain-like Protease,Replicase polyprotein 1a,ORF1a polyprotein,pp1a,1a,PL-PRO,Plpro
Drug Development Progress
治験薬の数27
市販薬剤の数7
研究＆開発段階Approved
ターゲットの別称
Papain-like proteinase，p65 homolog，MPro，SARS-CoV-2 3CLpro，3CL-PRO，GFL，Growth factor-like peptide，Leader protein，Non-structural protein 1，Non-structural protein 10，Non-structural protein 7，Non-structural protein 6，Non-structural protein 4，Non-structural protein 3，Non-structural protein 2，Non-structural protein 11，Non-structural protein 8，Non-structural protein 9，nsp1，nsp10，nsp11，nsp2，nsp3，nsp4，nsp5，nsp6，nsp7，nsp8，nsp9，ORF1a polyprotein，SARS coronavirus main proteinase，Replicase polyprotein 1a，pp1a，PL-PRO，PL2-PRO
バックグランド
New coronavirus is a single-stranded RNA positive-strand envelope type B coronavirus. Similar to the other two coronaviruses that cause SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome), its genome encodes non-structural, structural, and accessory proteins. Non-structural proteins include 3-chymotrypsin-like protease (3CLpro), papain-like protease, helicase, and RNA-dependent RNA polymerase (RNA -dependent RNA polymerase (RdRp). Structural proteins include spike glycoproteins. Papain in coronavirus is the same as 3CLpro. This enzyme operates on no less than 11 cleavage sites on the large polyprotein 1ab. Processing of polyproteins translated from viral RNA is essential. Therefore, press this The activity of this enzyme will prevent virus imitation.

Papain-like Protease 製品リスト

Species
  • SARS-CoV-2（1）
Tag
  • His Tag（1）
Host
  • E. coli（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
MoleculeCat. No.Product Name種HostStructurePurityActivitySize&Price
Papain-like Protease
PAE-C5148
SARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag (active enzyme)
SARS-CoV-2
E. coli
SDS-PAGE
Enzyme

$465.00

100ug
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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
EbselenSPI-1005; SPI-3005; PZ-51; DR-3305Phase 3 ClinicalDaiichi Sankyo Co Ltd, Sound Pharmaceuticals Inc
Bipolar Disorder; Cochlear Diseases; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Head and Neck Neoplasms; Hearing Loss; Hearing Loss, Noise-Induced; Lung Neoplasms; Meniere Disease; Neoplasms; Nervous System Diseases; Ototoxicity; Tinnitus
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SecutrelvirS-892216Phase 3 ClinicalShionogi & Co Ltd
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ibuzatrelvirPF-07817883; PF-7817883Phase 3 ClinicalPfizer Inc
Coronavirus Disease 2019 (COVID-19)
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MprosevirWPV-01Phase 3 ClinicalWestlake University
Coronavirus Disease 2019 (COVID-19)
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QLS-1128QLS-1128Phase 3 ClinicalQilu Pharmaceutical Co Ltd
Coronavirus Disease 2019 (COVID-19)
詳細
MIR-19MIR-19Phase 3 ClinicalSt. Petersburg Scientific Research Institute of Vaccines and Sera
Coronavirus Disease 2019 (COVID-19)
詳細
BofutrelvirFB-2001; DC-402234Phase 3 ClinicalFrontier Biotechnologies Inc, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
Coronavirus Disease 2019 (COVID-19)
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NirmatrelvirPF-07321332Phase 3 ClinicalPfizer As
Coronavirus Disease 2019 (COVID-19); Hepatic Insufficiency; Post-Acute COVID-19 Syndrome
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CDI-988CDI988Phase 2 ClinicalCocrystal Pharma Inc
Coronavirus Disease 2019 (COVID-19); Norovirus Infections
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Travatrelvir83-0060; TRX-01Phase 2 ClinicalTraws Pharma Inc
Coronavirus Disease 2019 (COVID-19)
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DeusitrelvirSHEN-211; SHEN211Phase 2 ClinicalHubei JKT BioPharma Co Ltd
Coronavirus Disease 2019 (COVID-19)
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HS-10517HS-10517; HS10517Phase 2 ClinicalJiangsu Hansoh Pharmaceutical Group Co Ltd, Shanghai Hansoh Biomedical Co Ltd
Coronavirus Disease 2019 (COVID-19)
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ZevotrelvirEDP-235Phase 2 ClinicalEnanta Pharmaceuticals Inc
Coronavirus Disease 2019 (COVID-19)
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TollovirPhase 2 ClinicalTodos Medical Ltd
Coronavirus Disease 2019 (COVID-19)
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SNB-011SNB-01; SNB-011Phase 2 ClinicalSyneurx International (Taiwan) Corp
Coronavirus Disease 2019 (COVID-19)
詳細
PomotrelvirPBI-0451Phase 1 ClinicalPardes Biosciences Inc
Coronavirus Disease 2019 (COVID-19)
詳細
CMX-990CMX-990; CMX990Phase 1 ClinicalThe Scripps Research Institute Inc
Coronavirus Disease 2019 (COVID-19)
詳細
WPV-02WPV-02; WPV02Phase 1 ClinicalWestlake Pharmaceuticals (Hangzhou) Co Ltd
Virus Diseases
詳細
ISM-3312ISM-3312Phase 1 ClinicalInsilico Medicine Ltd
Coronavirus Disease 2019 (COVID-19)
詳細
LimnetrelvirABBV-903Phase 1 ClinicalAbbvie Inc
詳細
SAL-0133SAL-0133Phase 1 ClinicalShenzhen Salubris Pharmaceuticals Co Ltd
Coronavirus Disease 2019 (COVID-19)
詳細
SYH-2055SYH-2055Phase 1 ClinicalCSPC Pharmaceutical Group Ltd
Coronavirus Disease 2019 (COVID-19)
詳細
AtilotrelvirGST-HG171Phase 1 ClinicalFujian Guangsheng Zhonglin Biotechnology Co Ltd
Coronavirus Disease 2019 (COVID-19)
詳細
ALG-097558ALG-097558Phase 1 ClinicalAligos Therapeutics Inc, Centre for Drug Design and Discovery, Rega Institute for Medical Research
Coronavirus Disease 2019 (COVID-19)
詳細
ASC11ASC-11Phase 1 ClinicalAscletis Pharma Inc
Coronavirus Disease 2019 (COVID-19)
詳細
LufotrelvirPF-07304814Phase 1 ClinicalPfizer Inc
Coronavirus Disease 2019 (COVID-19); Virus Diseases
詳細
GS221GS-221; GS221ClinicalGrand Pharmaceutical （China） Co Ltd
Coronavirus Disease 2019 (COVID-19)
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
OlgotrelvirSTI-1558; STI1558ApprovedTexas A&M UniversityOvydso, 奥维宁Mainland ChinaCoronavirus Disease 2019 (COVID-19)Zhejiang Acea Pharmaceutical Co Ltd2025-10-28
Coronavirus Disease 2019 (COVID-19); Pulmonary Disease, Chronic Obstructive
詳細
Atilotrelvir/RitonavirApprovedFujian Guangsheng Zhonglin Biotechnology Co Ltd泰中定Mainland ChinaCoronavirus Disease 2019 (COVID-19)Fujian Guangsheng Zhonglin Biotechnology Co Ltd2023-11-23
Coronavirus Disease 2019 (COVID-19)
詳細
SimnotrelvirSIM-0417; SSD-8432; VV-934ApprovedJiangsu Simcere Pharmaceutical Co LtdMainland ChinaCoronavirus Disease 2019 (COVID-19)Jiangsu Simcere Pharmaceutical Co Ltd2023-01-28
Coronavirus Disease 2019 (COVID-19)
詳細
LeritrelvirRAY003; RAY-003; RAY-1216ApprovedGuangdong Raynovent Biotech Co Ltd乐睿灵Mainland ChinaCoronavirus Disease 2019 (COVID-19)Guangdong Raynovent Biotech Co Ltd2023-03-23
Acute Kidney Injury; Coronavirus Disease 2019 (COVID-19); Hepatic Insufficiency
詳細
Simnotrelvir/RitonavirSIM-0417/Ritonavir; SSD-8432 / Ritonavir; SIM-0417 / Ritonavir; VV934 / RitonavirApprovedJiangsu Simcere Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Wuhan Institute Of Virology, Chinese Academy Of Sciences先诺欣Mainland ChinaCoronavirus Disease 2019 (COVID-19)Jiangsu Simcere Pharmaceutical Co Ltd2023-01-28
Coronavirus Disease 2019 (COVID-19); Hepatic Insufficiency; Renal Insufficiency
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Ensitrelvir Fumaric AcidS-217622ApprovedHokkaido University, Shionogi & Co LtdXocovaJapanCoronavirus Disease 2019 (COVID-19)Shionogi & Co Ltd2022-11-22
Coronavirus Disease 2019 (COVID-19); Hepatic Insufficiency; Post-Acute COVID-19 Syndrome; Renal Insufficiency
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Nirmatrelvir/RitonavirApprovedPfizer IncPaxlovid, 瑞派乐EUCoronavirus Disease 2019 (COVID-19)Pfizer Europe Ma Eeig2022-01-28
Coronavirus Disease 2019 (COVID-19); Immunologic Deficiency Syndromes; Post-Acute COVID-19 Syndrome; Postural Orthostatic Tachycardia Syndrome
詳細
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