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Prolactin R

Prolactin R 詳細

英語名	Prolactin receptor	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin
研究＆開発段階	Phase 3 Clinical

英語名	Prolactin receptor
ターゲットの別称	PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 3 Clinical

Prolactin R 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Human (4)Cynomolgus (1)Rat (1)Mouse (1)
タグ
Fc Tag (1)His Tag (5)His Tag & Avi Tag (1)
マーカー
Unconjugated (6)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
PRP-H5251	Human	HEK293	Human Prolactin R / PRLR Protein, Fc Tag
PRR-H52H3	Human	HEK293	Human Prolactin R / PRLR Protein, His Tag&Tag Free, low endotoxin (MALS verified)
PRR-H52Ha	Human	HEK293	Human Prolactin R / PRLR Protein, His Tag
PRR-H82E3	Human	HEK293	Biotinylated Human Prolactin R / PRLR Protein, His,Avitag™ (MALS verified)
PRR-M52H3	Mouse	HEK293	Mouse Prolactin R / PRLR Protein, His Tag (MALS & SPR verified)
PRR-C52H3	Cynomolgus	HEK293	Cynomolgus Prolactin R Protein, His Tag (MALS verified)
PRR-R52H3	Rat	HEK293	Rat Prolactin R / PRLR Protein, His Tag (MALS & SPR verified)

総数量7

Prolactin Rバックグランド

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

Prolactin R分子の別称

Prolactin R,PRLR,PRL-R

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
BAY-1158061	BAY-1158061; HMI-115	Phase 3 Clinical	Bayer AG	Alopecia; Endometriosis; Pain	詳細
ABS-201	ABS-201	Phase 2 Clinical	Absci Corp	Alopecia; Skin Diseases	詳細