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Sortilin

Sortilin 詳細

英語名	Sortilin	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
研究＆開発段階	Phase 2 Clinical

英語名	Sortilin
ターゲットの別称	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

Sortilin 製品リスト

属性
Protein (5)Cell (1)
製品ライブラリ
オンライン (6)
種
Human (3)Cynomolgus (1)Rat (1)Canine (1)
タグ
His Tag (4)His Tag & Avi Tag (1)- (1)
マーカー
Unconjugated (4)Biotin-labeled (1)- (1)

製品番号	種	発現システム	製品説明
CHEK-ATP155	Human	HEK293	HEK293/Human SORT1 Stable Cell Line
SON-H52H5	Human	HEK293	Human Sortilin / SORT1 Protein, His Tag, low endotoxin (MALS verified)
SON-H82E9	Human	HEK293	Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS & SPR verified)
SON-C52H3	Cynomolgus	HEK293	Cynomolgus Sortilin Protein, His Tag
SON-C52H4	Canine	HEK293	Canine Sortilin Protein, His Tag
SON-R52H3	Rat	HEK293	Rat Sortilin Protein, His Tag (MALS verified)

総数量6

Sortilinバックグランド

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Sortilin分子の別称

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
VES-001	VES001; VES-001	Phase 2 Clinical	Vesper Bio APS	Dementia; Frontotemporal Dementia; Frontotemporal Lobar Degeneration	詳細
Latozinemab	AL-001; GSK-4527223	Phase 1 Clinical	Alector Inc, Glaxosmithkline Plc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Neurodegenerative Diseases	詳細
ARB-1-6	ARB-1-6; PQ-203	Phase 1 Clinical	ProteinQure Inc	Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細