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TGF-beta RI

TGF-beta RI 詳細

英語名	Transforming growth factor beta receptor 1	市販薬剤の数	0
治験薬の数	7	ターゲットの別称	EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，Transforming Growth Factor Beta Receptor I，Multiple Self-Healing Squamous Epithelioma，TBR-I，Receptor， Transforming Growth Factor-beta Type I，EC:2.7.11.30
研究＆開発段階	Phase 3 Clinical

英語名	Transforming growth factor beta receptor 1
ターゲットの別称	EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，Transforming Growth Factor Beta Receptor I，Multiple Self-Healing Squamous Epithelioma，TBR-I，Receptor， Transforming Growth Factor-beta Type I，EC:2.7.11.30
市販薬剤の数	0
治験薬の数	7
研究＆開発段階	Phase 3 Clinical

TGF-beta RI 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
Llama IgG Fc Tag (1)Fc Tag (1)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
TG1-H5254	Human	HEK293	Human TGF-beta RI Protein, Fc Tag, low endotoxin (MALS verified)
TG1-H5259	Human	HEK293	Human TGFR-1 / ALK-5 / TGF-beta receptor type-1 Protein, Llama IgG2b Fc Tag (SPR verified)

総数量2

TGF-beta RIバックグランド

TGF type I receptor also called the activin receptor-like kinase 5 (ALK5) and involved in TGF signaling. TGFβ signaling is mediated by the interaction of TGFβ ligands (TGFβ 1, 2 or 3) with cell surface receptors, the TGF type I, type II and type III receptors. Signaling is initiated by binding of TGF to the TGF type II receptor forming a ligand-receptor complex which interacts with the TGF type I receptor.

TGF-beta RI分子の別称

TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Galunisertib	LY-2157299	Phase 3 Clinical	Eli Lilly And Company	Amyotrophic Lateral Sclerosis; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Glioblastoma; Glioma; Liver Neoplasms; Metastatic breast cancer; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細
GF-101	GFH-018; GF-101; GFH018	Phase 2 Clinical	Genfleet Therapeutics (Shanghai) Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Liver Neoplasms; Pancreatic Neoplasms; Solid tumours	詳細
Tosposertib phosphate	TU-2218; NCE401; NCE-401	Phase 2 Clinical	TiumBio Co Ltd	Idiopathic Pulmonary Fibrosis; Solid tumours	詳細
Ontunisertib	ORG-129; AGMB-129	Phase 2 Clinical	Origo Biopharma Sociedad Litmitada	Crohn Disease	詳細
TRK-250	TRK-250; BNC-1021	Phase 1 Clinical	Bonac Corp	Idiopathic Pulmonary Fibrosis	詳細
Oxinseti	SH-3051	Phase 1 Clinical	Nanjing Sanhome Pharmaceutical Co Ltd	Liver Neoplasms; Solid tumours	詳細
AGMB-447	AGMB-447; ORG-447	Phase 1 Clinical	AgomAb Therapeutics NV	Idiopathic Pulmonary Fibrosis	詳細