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TRAIL R1

TRAIL R1 詳細

英語名	Tumor necrosis factor receptor superfamily member 10A	市販薬剤の数	1
治験薬の数	3	ターゲットの別称	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
研究＆開発段階	Approved

英語名	Tumor necrosis factor receptor superfamily member 10A
ターゲットの別称	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
市販薬剤の数	1
治験薬の数	3
研究＆開発段階	Approved

TRAIL R1 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (1)Fc Tag (1)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
TR1-H5228	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
TR1-H5254	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

総数量2

TRAIL R1バックグランド

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1分子の別称

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Dulanermin (Shanghai GeBaiDe)		Phase 3 Clinical	Shanghai Gebaide Biotechnology Co Ltd	Carcinoma, Non-Small-Cell Lung	詳細
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech)		Phase 3 Clinical	Shenzhen Sinobioway Xinpeng Biomedicine Co Ltd	Neoplasms	詳細
HLX56	HLX56; HLX-56	Phase 1 Clinical		Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Aponermin		Approved	Beijing Shadong Biotech Co Ltd	沙艾特, Shaite	Mainland China	Multiple Myeloma	Wuhan Hiteck Biological Pharma Co Ltd	2023-11-02	Multiple Myeloma	詳細

レビュー

1***22019-09-30
0評価
Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
I purchased TNFRSF10A to measure the binding. I tested the purity first. From the results of the SEC (see attachment), you can see the purity is pretty good, 94.8%.