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TROP-2

TROP-2 Overview

English Name	Tumor-associated calcium signal transducer 2	Approved Drugs	3
Drugs in Clinical Trials	50	Target Synonym	Tumor-associated calcium signal transducer 2，M1S1，TROP2，TACSTD2，Pancreatic carcinoma marker protein GA733-1，Tumor Associated Calcium Signal Transducer 2，GA733-1，Membrane Component， Chromosome 1， Surface Marker 1，Gastrointestinal Tumor-Associated Antigen GA7331，Pancreatic Carcinoma Marker Protein GA7331，Cell surface glycoprotein Trop-2，Membrane component chromosome 1 surface marker 1，40kD Glycoprotein， Identified By Monoclonal Antibody GA733，Cell Surface Glycoprotein TROP2，Epithelial Glycoprotein-1，Truncated TACSTD2，GA7331，EGP-1，EGP1，GP50，Trophoblast Cell Surface Antigen 2
Highest Development Stage	Approved

English Name	Tumor-associated calcium signal transducer 2
Target Synonym	Tumor-associated calcium signal transducer 2，M1S1，TROP2，TACSTD2，Pancreatic carcinoma marker protein GA733-1，Tumor Associated Calcium Signal Transducer 2，GA733-1，Membrane Component， Chromosome 1， Surface Marker 1，Gastrointestinal Tumor-Associated Antigen GA7331，Pancreatic Carcinoma Marker Protein GA7331，Cell surface glycoprotein Trop-2，Membrane component chromosome 1 surface marker 1，40kD Glycoprotein， Identified By Monoclonal Antibody GA733，Cell Surface Glycoprotein TROP2，Epithelial Glycoprotein-1，Truncated TACSTD2，GA7331，EGP-1，EGP1，GP50，Trophoblast Cell Surface Antigen 2
Approved Drugs	3
Drugs in Clinical Trials	50
Highest Development Stage	Approved

TROP-2 Product List

Product Category
Protein (18)Beads (1)Antibody (1)Kits (1)
Product Status
Launched (21)
Species
Human (9)Mouse (4)Rhesus macaque (4)Canine (1)Rabbit (1)Cynomolgus (2)
Tag
His Tag (8)His Tag & Avi Tag (5)Fc Tag (2)- (3)Fc Tag & Avi Tag (3)
Conjugate
Unconjugated (11)Biotin-labeled (8)- (2)

Cat. No.	Species	Host	Product Description
HOT CEA-B032	Human	-	Human Soluble TROP-2 ELISA Kit, PRO
HOT TR2-H5223	Human	HEK293	Human TROP-2 / TACSTD2 Protein, His Tag, low endotoxin (MALS verified)
HOT TR2-H5253	Human	HEK293	Human TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
HOT TR2-H82E5	Human	HEK293	Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
HOT TR2-M82E9	Mouse	HEK293	Biotinylated Mouse TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
MBS-K028	Human	-	Human TROP-2-coupled Magnetic Beads
TR2-H52H4	Human	HEK293	Human TROP-2 / TACSTD2 Protein, His Tag, Ultra Low Endotoxin (MALS verified)
TR2-H52H6	Human	HEK293	Human TROP-2 / TACSTD2 (88-274) Protein, His Tag (MALS verified)
TR2-H82Ea	Human	HEK293	Biotinylated Human TROP-2 / TACSTD2 (88-274) Protein, His,Avitag™ (MALS verified)
TR2-H82F4	Human	HEK293	Biotinylated Human TROP-2 / TACSTD2 Protein, Fc,Avitag™

Total: 21

TROP-2 Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 Synonyms

TACSTD2,GA733-1,M1S1,TROP2

Antibody Project Trading Platform

Project Name	Project Stage	Molecule Type	Molecule Source	Disease Area	Indication
Trop2 ADC -01	IND	ADC	Humanized Mouse	Solid Tumor	Non-small cell lung cancer,Pancreatic cancer

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
[68Ga]Ga-NOTA-T4		Phase 3 Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
[18F]F-RESCA-T4		Phase 3 Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
[18F]F-RESCA-RT4		Phase 3 Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
[68Ga]Ga-NOTA-RT4		Phase 3 Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
JSKN-016	JSKN-016; JSKN016	Phase 3 Clinical	Jiangsu Alphamab Biopharmaceuticals Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastroesophageal Junction Neoplasms; Metastatic breast cancer; Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	Details
SHR-A1921	SHR-A1921; SHRA1921; SHR-1921	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd	Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Salivary Gland Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
ESG-401	STI-3258; OQY-3258; ESG-401	Phase 3 Clinical	Shanghai Escugen Biotechnology Co Ltd	Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	Details
FDA018 Antibody Drug Conjugate	FDA018-ADC; FDA-018-ADC; F0024	Phase 3 Clinical	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd	Breast Neoplasms; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
GQ-1010	PBI-410; GQ1010; BHV1510; BHV-1510; GQ-1010	Phase 2 Clinical	GeneQuantum Healthcare (Suzhou) Co Ltd	Carcinoma; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms	Details
TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center)		Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis	Details
ASP-2998	ASP-2998; ASP2998	Phase 2 Clinical	Astellas Pharma Global Development Inc	Solid tumours	Details
Trop2-ADC (Sun Yat-Sen Memorial Hospital Of Sun Yat-Sen University)		Phase 2 Clinical	Sun Yat-Sen Memorial Hospital Of Sun Yat-Sen University	Triple Negative Breast Neoplasms	Details
VBC-103	AVZO-103; VAC-103; VBC-103; VBC103	Phase 2 Clinical	VelaVigo Cayman Ltd	Carcinoma; Carcinoma, Transitional Cell; Solid tumours; Triple Negative Breast Neoplasms	Details
IBI-3014	IBI3014; IBI-3014	Phase 2 Clinical		Solid tumours	Details
Trop2 CAR-NK cell therapy(Henan Provincial Cancer Hospital)		Phase 2 Clinical	Henan Provincial Cancer Hospital	Carcinoma, Non-Small-Cell Lung	Details
MDX-2001	MDX2001; MDX-2001	Phase 2 Clinical	ModeX Therapeutics Inc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Thyroid Neoplasms; Uterine Cervical Neoplasms	Details
OBI-902	OBI-902	Phase 2 Clinical	Obi Pharma Inc	Neoplasms; Solid tumours	Details
OBI-992	BSI-992; BSI992; R-992; OBI-992	Phase 2 Clinical	Biosion Inc	Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms	Details
HS-20105	HS-20105; HS20105	Phase 2 Clinical	Hansoh BioMedical R&D Company	Solid tumours	Details
IBI130	IBI130; IBI-130	Phase 2 Clinical		Neoplasm Metastasis; Solid tumours	Details
Anti TROP2 antibody drug conjugate ADC（Fudan University）		Phase 2 Clinical	Fudan University	Triple Negative Breast Neoplasms	Details
XYD-9668-198	XYD-9668-198	Phase 2 Clinical	Kunshan Xinyunda Biotechnology Co Ltd	Solid tumours	Details
9MW-2921	9MW2921; 9MW-2921	Phase 2 Clinical	Mabwell (Shanghai) Bioscience Co Ltd	Solid tumours	Details
MHB036C	MHB-036C	Phase 2 Clinical	Minghui Pharmaceutical Pty Ltd	Breast Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours	Details
BAT-8008	BAT-8008; BAT8008	Phase 2 Clinical	Bio-Thera Solutions Ltd	Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms	Details
DB-1305	DB1305; BNT325; BNT-325; DB-1305	Phase 2 Clinical	Duality Biologics (Suzhou) Co Ltd	Solid tumours	Details
BIO-106	BIO-106	Phase 2 Clinical	Hangzhou Baikai Biopharmaceutical Co Ltd	Neoplasms; Solid tumours	Details
BL-M02D1		Phase 2 Clinical	Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Digestive System Neoplasms; Gastrointestinal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
LCB-84	LCB-84	Phase 2 Clinical	Legochem Biosciences Inc	Solid tumours	Details
DAC-002	JS-108; DAC-002/JS108; DAC-002	Phase 1 Clinical	Hangzhou Dac Biotech Company Ltd	Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms	Details
AK-146-D-1	AK146D1; AK-146-D1	Phase 1 Clinical		Solid tumours	Details
KH-815	KH815; KH-815	Phase 1 Clinical	Chengdu Kanghong Biotechnologies Co Ltd	Solid tumours	Details
IBI-3007	IBI3007; IBI-3007	Phase 1 Clinical		Solid tumours	Details
BL-M19D1	BL-M08D1; BL-M19D1	Phase 1 Clinical	Sichuan Biokin Pharmaceutical Co Ltd	Lymphatic Diseases; Lymphoma; Neoplasm Metastasis; Solid tumours	Details
HS-20124	HS-20124; HS20124	Phase 1 Clinical	Hansoh BioMedical R&D Company	Solid tumours	Details
IBR-822	IBR822; IBR-822	Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	Details
DXC-1002	DXC1002; DXC-1002	Phase 1 Clinical	Hangzhou Dac Biotech Company Ltd	Solid tumours	Details
DS-001	DS001; DS-001	Phase 1 Clinical	Dartsbio Pharmaceuticals Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Neoplasms	Details
FZ-AD004	F0040; FZ-AD004	Phase 1 Clinical	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd	Solid tumours	Details
U87 CAR-T cell therapy(Unicar-Therapy Bio-Medicine Technology)	U-87	Phase 1 Clinical	Shanghai Unicar-Therapy Bio-Medicine Technology Co Ltd	Head and Neck Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
BCG-011	DM-001; BCG-011	Phase 1 Clinical		Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
MT-302	MT-302	Phase 1 Clinical	Myeloid Therapeutics Inc	Breast Neoplasms; Carcinoma; Colonic Neoplasms; Lung Neoplasms	Details
99mTc-radiolabeled TROP2 targeting nanobody (Shanghai Novamab Biopharmaceuticals/Chinese Academy of Sciences/Peking Union Medical College Hospital/Peking University)		Clinical	Peking University	Breast Neoplasms; Triple Negative Breast Neoplasms	Details
99mTc-MY6349	99mTc-MY-6349	Clinical	Peking Union Medical College Hospital	Breast Neoplasms	Details
68Ga-THP-Trop2 VHH		Clinical	The First Affiliated Hospital Of Xiamen University	Thyroid Neoplasms	Details
[18F]F-RESCA-EPCD6		Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung	Details
[68Ga]Ga-NOTA-EPCD6		Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Carcinoma, Non-Small-Cell Lung	Details
89Zr-DFO-hSR7		Clinical	Beijing Cancer Hospital	Triple Negative Breast Neoplasms	Details
TROP-2-targeted anti-CD74 siRNA (Immunomedics)			Immunomedics Inc	Solid tumours	Details
68Ga-TROP2			Fudan University		Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Sacituzumab govitecan	IMMU-132; TROP-2-SN-38; IMMU0132; IMMU-0132; GS-0132	Approved	Gilead Sciences Inc, Ibc Pharmaceuticals Inc, Immunomedics Inc, Unicancer	Trodelvy, 拓达维, TRODELVY	United States	Triple Negative Breast Neoplasms	Immunomedics Inc	2020-04-22	Alopecia; Bile Duct Neoplasms; Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Glioblastoma; Hormone-Resistant Prostate Neoplasms; Klatskin Tumor; Liver Failure; Lung Neoplasms; Mesothelioma; Metastatic breast cancer; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymoma; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
Datopotamab deruxtecan	DS-1062a; DS-1062; S-1062a	Approved	Daiichi Sankyo Co Ltd	Datroway, DATROWAY, 达卓优	Japan	Breast Neoplasms	Daiichi Sankyo Co Ltd	2024-12-27	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasm, Residual; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	Details
Sacituzumab tirumotecan	SKB264; SKB-264; MK-2870; sac-TMT	Approved	Klus Pharma Inc	佳泰莱	Mainland China	Triple Negative Breast Neoplasms	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	2024-11-22	Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; HR-positive breast cancer; Metastatic breast cancer; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Stuttering; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details

Product Reviews

M***g2023-07-06
1People Like
Human TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
This protein was used to immunize mice for antibody development. Proteins were mixed with CFA/IFA and immunized intraperitoneally. Mice were boosted every 14 days for 5 boosts following initial immunization. Serum titers were measured by ELISA following Days 0, 43, and 65. Of the two mice immunized with this protein, only one mouse developed an antibody response as low signal was detected at day 65.
V***w2023-02-21
3People Like
Human TROP-2 / TACSTD2 Protein, His Tag, low endotoxin (MALS verified)
Acro and their customer support are super helpful. Products ordered arrived in a timely manner. Customer support personal are as friendly as they are insightful. Never have they disappointed when purchasing any of their products. Such a user friendly website and if anything is not found customer support never backs down to help out! Acro’s personal are very friendly and knowledgeable. They were friendly and helpful when resolving this issue.
E***l2022-10-26
2People Like
Human TROP-2 / TACSTD2 Protein, His Tag, low endotoxin (MALS verified)
Acro’s customer support is always super helpful and quick to respond. When products are ordered, the arrive in a timely manner. Acro’s personal are very friendly and knowledgeable. They never disappoint when it comes to finding a solution to a problem. Having such a user-friendly website helps a lot in finding the right product needed and if something cannot be found customer support always finds a way!