| Project Name | Project Stage | Molecule Type | Molecule Source | Disease Area | Indication |
|---|---|---|---|---|---|
| Trop2 ADC -01 | IND | ADC | Humanized Mouse | Solid Tumor | Non-small cell lung cancer,Pancreatic cancer |
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| [68Ga]Ga-NOTA-T4 | Phase 3 Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details | |
| [18F]F-RESCA-T4 | Phase 3 Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details | |
| [18F]F-RESCA-RT4 | Phase 3 Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details | |
| [68Ga]Ga-NOTA-RT4 | Phase 3 Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details | |
| JSKN-016 | JSKN-016; JSKN016 | Phase 3 Clinical | Jiangsu Alphamab Biopharmaceuticals Co Ltd | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastroesophageal Junction Neoplasms; Metastatic breast cancer; Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms | Details |
| SHR-A1921 | SHR-A1921; SHRA1921; SHR-1921 | Phase 3 Clinical | Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd | Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Salivary Gland Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details |
| ESG-401 | STI-3258; OQY-3258; ESG-401 | Phase 3 Clinical | Shanghai Escugen Biotechnology Co Ltd | Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | Details |
| FDA018 Antibody Drug Conjugate | FDA018-ADC; FDA-018-ADC; F0024 | Phase 3 Clinical | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd | Breast Neoplasms; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details |
| GQ-1010 | PBI-410; GQ1010; BHV1510; BHV-1510; GQ-1010 | Phase 2 Clinical | GeneQuantum Healthcare (Suzhou) Co Ltd | Carcinoma; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms | Details |
| TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center) | Phase 2 Clinical | The University Of Texas MD Anderson Cancer Center | Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis | Details | |
| ASP-2998 | ASP-2998; ASP2998 | Phase 2 Clinical | Astellas Pharma Global Development Inc | Solid tumours | Details |
| Trop2-ADC (Sun Yat-Sen Memorial Hospital Of Sun Yat-Sen University) | Phase 2 Clinical | Sun Yat-Sen Memorial Hospital Of Sun Yat-Sen University | Triple Negative Breast Neoplasms | Details | |
| VBC-103 | AVZO-103; VAC-103; VBC-103; VBC103 | Phase 2 Clinical | VelaVigo Cayman Ltd | Carcinoma; Carcinoma, Transitional Cell; Solid tumours; Triple Negative Breast Neoplasms | Details |
| IBI-3014 | IBI3014; IBI-3014 | Phase 2 Clinical | Solid tumours | Details | |
| Trop2 CAR-NK cell therapy(Henan Provincial Cancer Hospital) | Phase 2 Clinical | Henan Provincial Cancer Hospital | Carcinoma, Non-Small-Cell Lung | Details | |
| MDX-2001 | MDX2001; MDX-2001 | Phase 2 Clinical | ModeX Therapeutics Inc | Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Thyroid Neoplasms; Uterine Cervical Neoplasms | Details |
| OBI-902 | OBI-902 | Phase 2 Clinical | Obi Pharma Inc | Neoplasms; Solid tumours | Details |
| OBI-992 | BSI-992; BSI992; R-992; OBI-992 | Phase 2 Clinical | Biosion Inc | Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms | Details |
| HS-20105 | HS-20105; HS20105 | Phase 2 Clinical | Hansoh BioMedical R&D Company | Solid tumours | Details |
| IBI130 | IBI130; IBI-130 | Phase 2 Clinical | Neoplasm Metastasis; Solid tumours | Details | |
| Anti TROP2 antibody drug conjugate ADC(Fudan University) | Phase 2 Clinical | Fudan University | Triple Negative Breast Neoplasms | Details | |
| XYD-9668-198 | XYD-9668-198 | Phase 2 Clinical | Kunshan Xinyunda Biotechnology Co Ltd | Solid tumours | Details |
| 9MW-2921 | 9MW2921; 9MW-2921 | Phase 2 Clinical | Mabwell (Shanghai) Bioscience Co Ltd | Solid tumours | Details |
| MHB036C | MHB-036C | Phase 2 Clinical | Minghui Pharmaceutical Pty Ltd | Breast Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours | Details |
| BAT-8008 | BAT-8008; BAT8008 | Phase 2 Clinical | Bio-Thera Solutions Ltd | Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms | Details |
| DB-1305 | DB1305; BNT325; BNT-325; DB-1305 | Phase 2 Clinical | Duality Biologics (Suzhou) Co Ltd | Solid tumours | Details |
| BIO-106 | BIO-106 | Phase 2 Clinical | Hangzhou Baikai Biopharmaceutical Co Ltd | Neoplasms; Solid tumours | Details |
| BL-M02D1 | Phase 2 Clinical | Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Digestive System Neoplasms; Gastrointestinal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details | |
| LCB-84 | LCB-84 | Phase 2 Clinical | Legochem Biosciences Inc | Solid tumours | Details |
| DAC-002 | JS-108; DAC-002/JS108; DAC-002 | Phase 1 Clinical | Hangzhou Dac Biotech Company Ltd | Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms | Details |
| AK-146-D-1 | AK146D1; AK-146-D1 | Phase 1 Clinical | Solid tumours | Details | |
| KH-815 | KH815; KH-815 | Phase 1 Clinical | Chengdu Kanghong Biotechnologies Co Ltd | Solid tumours | Details |
| IBI-3007 | IBI3007; IBI-3007 | Phase 1 Clinical | Solid tumours | Details | |
| BL-M19D1 | BL-M08D1; BL-M19D1 | Phase 1 Clinical | Sichuan Biokin Pharmaceutical Co Ltd | Lymphatic Diseases; Lymphoma; Neoplasm Metastasis; Solid tumours | Details |
| HS-20124 | HS-20124; HS20124 | Phase 1 Clinical | Hansoh BioMedical R&D Company | Solid tumours | Details |
| IBR-822 | IBR822; IBR-822 | Phase 1 Clinical | Imbioray (Hangzhou) Biomedicine Co Ltd | Solid tumours | Details |
| DXC-1002 | DXC1002; DXC-1002 | Phase 1 Clinical | Hangzhou Dac Biotech Company Ltd | Solid tumours | Details |
| DS-001 | DS001; DS-001 | Phase 1 Clinical | Dartsbio Pharmaceuticals Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Neoplasms | Details |
| FZ-AD004 | F0040; FZ-AD004 | Phase 1 Clinical | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd | Solid tumours | Details |
| U87 CAR-T cell therapy(Unicar-Therapy Bio-Medicine Technology) | U-87 | Phase 1 Clinical | Shanghai Unicar-Therapy Bio-Medicine Technology Co Ltd | Head and Neck Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details |
| BCG-011 | DM-001; BCG-011 | Phase 1 Clinical | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details | |
| MT-302 | MT-302 | Phase 1 Clinical | Myeloid Therapeutics Inc | Breast Neoplasms; Carcinoma; Colonic Neoplasms; Lung Neoplasms | Details |
| 99mTc-radiolabeled TROP2 targeting nanobody (Shanghai Novamab Biopharmaceuticals/Chinese Academy of Sciences/Peking Union Medical College Hospital/Peking University) | Clinical | Peking University | Breast Neoplasms; Triple Negative Breast Neoplasms | Details | |
| 99mTc-MY6349 | 99mTc-MY-6349 | Clinical | Peking Union Medical College Hospital | Breast Neoplasms | Details |
| 68Ga-THP-Trop2 VHH | Clinical | The First Affiliated Hospital Of Xiamen University | Thyroid Neoplasms | Details | |
| [18F]F-RESCA-EPCD6 | Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung | Details | |
| [68Ga]Ga-NOTA-EPCD6 | Clinical | Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Carcinoma, Non-Small-Cell Lung | Details | |
| 89Zr-DFO-hSR7 | Clinical | Beijing Cancer Hospital | Triple Negative Breast Neoplasms | Details | |
| TROP-2-targeted anti-CD74 siRNA (Immunomedics) | Immunomedics Inc | Solid tumours | Details | ||
| 68Ga-TROP2 | Fudan University | Details |
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Sacituzumab govitecan | IMMU-132; TROP-2-SN-38; IMMU0132; IMMU-0132; GS-0132 | Approved | Gilead Sciences Inc, Ibc Pharmaceuticals Inc, Immunomedics Inc, Unicancer | Trodelvy, 拓达维, TRODELVY | United States | Triple Negative Breast Neoplasms | Immunomedics Inc | 2020-04-22 | Alopecia; Bile Duct Neoplasms; Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Glioblastoma; Hormone-Resistant Prostate Neoplasms; Klatskin Tumor; Liver Failure; Lung Neoplasms; Mesothelioma; Metastatic breast cancer; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymoma; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details |
| Datopotamab deruxtecan | DS-1062a; DS-1062; S-1062a | Approved | Daiichi Sankyo Co Ltd | Datroway, DATROWAY, 达卓优 | Japan | Breast Neoplasms | Daiichi Sankyo Co Ltd | 2024-12-27 | Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasm, Residual; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | Details |
| Sacituzumab tirumotecan | SKB264; SKB-264; MK-2870; sac-TMT | Approved | Klus Pharma Inc | 佳泰莱 | Mainland China | Triple Negative Breast Neoplasms | Sichuan Kelun-Biotech Biopharmaceutical Co Ltd | 2024-11-22 | Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; HR-positive breast cancer; Metastatic breast cancer; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Stuttering; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details |




