TROP-2

TROP-2

TROP-2 Overview

Molecule Name
Tumor-associated calcium signal transducer 2
Synonyms
TACSTD2,GA733-1,M1S1,TROP2
Drug Development Progress
Drugs in Clinical Trials50
Approved Drugs3
Highest Development StageApproved
Target Synonym
Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein-1,Truncated TACSTD2,GA7331,EGP-1,EGP1,GP50,Trophoblast Cell Surface Antigen 2
Background
TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 Product List

Species
  • Human(7)
  • Rhesus macaque(4)
  • Mouse(3)
  • Cynomolgus(2)
  • Canine(1)
  • Rabbit(1)
Tag
  • His Tag(8)
  • His Tag & Avi Tag(5)
  • Fc Tag & Avi Tag(3)
  • Fc Tag(2)
Host
  • HEK293(18)
Conjugate
  • Unconjugated(10)
  • Biotin-labeled(8)
Grade
  • RUO(18)
Low Endotoxin
  • Yes(3)
  • No(15)
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Project NameProject StageMolecule TypeMolecule SourceDisease AreaIndication
Trop2 ADC -01INDADCHumanized MouseSolid TumorNon-small cell lung cancer,Pancreatic cancer
Project Name
Trop2 ADC -01
Project Stage
IND
Molecule Type
ADC
Molecule Source
Humanized Mouse
Disease Area
Solid Tumor
Indication
Non-small cell lung cancer,Pancreatic cancer
Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
[68Ga]Ga-NOTA-T4Phase 3 ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
[18F]F-RESCA-T4Phase 3 ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
[18F]F-RESCA-RT4Phase 3 ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
[68Ga]Ga-NOTA-RT4Phase 3 ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
JSKN-016JSKN-016; JSKN016Phase 3 ClinicalJiangsu Alphamab Biopharmaceuticals Co Ltd
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastroesophageal Junction Neoplasms; Metastatic breast cancer; Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms
Details
SHR-A1921SHR-A1921; SHRA1921; SHR-1921Phase 3 ClinicalShanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd
Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Salivary Gland Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
ESG-401STI-3258; OQY-3258; ESG-401Phase 3 ClinicalShanghai Escugen Biotechnology Co Ltd
Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms
Details
FDA018 Antibody Drug ConjugateFDA018-ADC; FDA-018-ADC; F0024Phase 3 ClinicalShanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
Breast Neoplasms; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
GQ-1010PBI-410; GQ1010; BHV1510; BHV-1510; GQ-1010Phase 2 ClinicalGeneQuantum Healthcare (Suzhou) Co Ltd
Carcinoma; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms
Details
TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center)Phase 2 ClinicalThe University Of Texas MD Anderson Cancer Center
Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis
Details
ASP-2998ASP-2998; ASP2998Phase 2 ClinicalAstellas Pharma Global Development Inc
Solid tumours
Details
Trop2-ADC (Sun Yat-Sen Memorial Hospital Of Sun Yat-Sen University)Phase 2 ClinicalSun Yat-Sen Memorial Hospital Of Sun Yat-Sen University
Triple Negative Breast Neoplasms
Details
VBC-103AVZO-103; VAC-103; VBC-103; VBC103Phase 2 ClinicalVelaVigo Cayman Ltd
Carcinoma; Carcinoma, Transitional Cell; Solid tumours; Triple Negative Breast Neoplasms
Details
IBI-3014IBI3014; IBI-3014Phase 2 Clinical
Solid tumours
Details
Trop2 CAR-NK cell therapy(Henan Provincial Cancer Hospital)Phase 2 ClinicalHenan Provincial Cancer Hospital
Carcinoma, Non-Small-Cell Lung
Details
MDX-2001MDX2001; MDX-2001Phase 2 ClinicalModeX Therapeutics Inc
Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Thyroid Neoplasms; Uterine Cervical Neoplasms
Details
OBI-902OBI-902Phase 2 ClinicalObi Pharma Inc
Neoplasms; Solid tumours
Details
OBI-992BSI-992; BSI992; R-992; OBI-992Phase 2 ClinicalBiosion Inc
Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms
Details
HS-20105HS-20105; HS20105Phase 2 ClinicalHansoh BioMedical R&D Company
Solid tumours
Details
IBI130IBI130; IBI-130Phase 2 Clinical
Neoplasm Metastasis; Solid tumours
Details
Anti TROP2 antibody drug conjugate ADC(Fudan University)Phase 2 ClinicalFudan University
Triple Negative Breast Neoplasms
Details
XYD-9668-198XYD-9668-198Phase 2 ClinicalKunshan Xinyunda Biotechnology Co Ltd
Solid tumours
Details
9MW-29219MW2921; 9MW-2921Phase 2 ClinicalMabwell (Shanghai) Bioscience Co Ltd
Solid tumours
Details
MHB036CMHB-036CPhase 2 ClinicalMinghui Pharmaceutical Pty Ltd
Breast Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours
Details
BAT-8008BAT-8008; BAT8008Phase 2 ClinicalBio-Thera Solutions Ltd
Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms
Details
DB-1305DB1305; BNT325; BNT-325; DB-1305Phase 2 ClinicalDuality Biologics (Suzhou) Co Ltd
Solid tumours
Details
BIO-106BIO-106Phase 2 ClinicalHangzhou Baikai Biopharmaceutical Co Ltd
Neoplasms; Solid tumours
Details
BL-M02D1Phase 2 ClinicalBaili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Digestive System Neoplasms; Gastrointestinal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
LCB-84LCB-84Phase 2 ClinicalLegochem Biosciences Inc
Solid tumours
Details
DAC-002JS-108; DAC-002/JS108; DAC-002Phase 1 ClinicalHangzhou Dac Biotech Company Ltd
Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms
Details
AK-146-D-1AK146D1; AK-146-D1Phase 1 Clinical
Solid tumours
Details
KH-815KH815; KH-815Phase 1 ClinicalChengdu Kanghong Biotechnologies Co Ltd
Solid tumours
Details
IBI-3007IBI3007; IBI-3007Phase 1 Clinical
Solid tumours
Details
BL-M19D1BL-M08D1; BL-M19D1Phase 1 ClinicalSichuan Biokin Pharmaceutical Co Ltd
Lymphatic Diseases; Lymphoma; Neoplasm Metastasis; Solid tumours
Details
HS-20124HS-20124; HS20124Phase 1 ClinicalHansoh BioMedical R&D Company
Solid tumours
Details
IBR-822IBR822; IBR-822Phase 1 ClinicalImbioray (Hangzhou) Biomedicine Co Ltd
Solid tumours
Details
DXC-1002DXC1002; DXC-1002Phase 1 ClinicalHangzhou Dac Biotech Company Ltd
Solid tumours
Details
DS-001DS001; DS-001Phase 1 ClinicalDartsbio Pharmaceuticals Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
Neoplasms
Details
FZ-AD004F0040; FZ-AD004Phase 1 ClinicalShanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
Solid tumours
Details
U87 CAR-T cell therapy(Unicar-Therapy Bio-Medicine Technology)U-87Phase 1 ClinicalShanghai Unicar-Therapy Bio-Medicine Technology Co Ltd
Head and Neck Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
BCG-011DM-001; BCG-011Phase 1 Clinical
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
MT-302MT-302Phase 1 ClinicalMyeloid Therapeutics Inc
Breast Neoplasms; Carcinoma; Colonic Neoplasms; Lung Neoplasms
Details
99mTc-radiolabeled TROP2 targeting nanobody (Shanghai Novamab Biopharmaceuticals/Chinese Academy of Sciences/Peking Union Medical College Hospital/Peking University)ClinicalPeking University
Breast Neoplasms; Triple Negative Breast Neoplasms
Details
99mTc-MY634999mTc-MY-6349ClinicalPeking Union Medical College Hospital
Breast Neoplasms
Details
68Ga-THP-Trop2 VHHClinicalThe First Affiliated Hospital Of Xiamen University
Thyroid Neoplasms
Details
[18F]F-RESCA-EPCD6ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung
Details
[68Ga]Ga-NOTA-EPCD6ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Carcinoma, Non-Small-Cell Lung
Details
89Zr-DFO-hSR7ClinicalBeijing Cancer Hospital
Triple Negative Breast Neoplasms
Details
TROP-2-targeted anti-CD74 siRNA (Immunomedics)Immunomedics Inc
Solid tumours
Details
68Ga-TROP2Fudan University
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
Sacituzumab govitecanIMMU-132; TROP-2-SN-38; IMMU0132; IMMU-0132; GS-0132ApprovedGilead Sciences Inc, Ibc Pharmaceuticals Inc, Immunomedics Inc, UnicancerTrodelvy, 拓达维, TRODELVYUnited StatesTriple Negative Breast NeoplasmsImmunomedics Inc2020-04-22
Alopecia; Bile Duct Neoplasms; Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Glioblastoma; Hormone-Resistant Prostate Neoplasms; Klatskin Tumor; Liver Failure; Lung Neoplasms; Mesothelioma; Metastatic breast cancer; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymoma; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
Datopotamab deruxtecanDS-1062a; DS-1062; S-1062aApprovedDaiichi Sankyo Co LtdDatroway, DATROWAY, 达卓优JapanBreast NeoplasmsDaiichi Sankyo Co Ltd2024-12-27
Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasm, Residual; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms
Details
Sacituzumab tirumotecanSKB264; SKB-264; MK-2870; sac-TMTApprovedKlus Pharma Inc佳泰莱Mainland ChinaTriple Negative Breast NeoplasmsSichuan Kelun-Biotech Biopharmaceutical Co Ltd2024-11-22
Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; HR-positive breast cancer; Metastatic breast cancer; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Stuttering; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
Customer Reviews
  • M***g2023-07-06
    This protein was used to immunize mice for antibody development. Proteins were mixed with CFA/IFA and immunized intraperitoneally. Mice were boosted every 14 days for 5 boosts following initial immunization. Serum titers were measured by ELISA following Days 0, 43, and 65. Of the two mice immunized with this protein, only one mouse developed an antibody response as low signal was detected at day 65.
  • V***w2023-02-21
    Acro and their customer support are super helpful. Products ordered arrived in a timely manner. Customer support personal are as friendly as they are insightful. Never have they disappointed when purchasing any of their products. Such a user friendly website and if anything is not found customer support never backs down to help out! Acro’s personal are very friendly and knowledgeable. They were friendly and helpful when resolving this issue.
  • E***l2022-10-26
    Acro’s customer support is always super helpful and quick to respond. When products are ordered, the arrive in a timely manner. Acro’s personal are very friendly and knowledgeable. They never disappoint when it comes to finding a solution to a problem. Having such a user-friendly website helps a lot in finding the right product needed and if something cannot be found customer support always finds a way!
  • 1***32022-08-10
    ACRO's antigens are well solubilized and encapsulated for antibody screening, and the method is now being established smoothly. Also, they provide us with complete technical support which can be given in various aspects for any problems that arise during the test.
  • 1***72019-10-11
    We used ELISA method to detect the binding activity of the antibody. The antigen concentration is 0.1ug / mL (100ul/well). It was able to bind with our antibodies and the linear range is 0.001-1ug / mL. The bioactivity was pretty high.