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CD27 Ligand

CD27 Ligand 詳細

英語名	CD70 antigen	市販薬剤の数	0
治験薬の数	37	ターゲットの別称	CD70 antigen，Surface Antigen CD70，LPFS3，CD27L，Tumor necrosis factor ligand superfamily member 7，CD27LG，CD27-L，CD70，CD70 Molecule，TNFSF7，Tumor Necrosis Factor (Ligand) Superfamily， Member 7，Tumor Necrosis Factor Ligand 8A，Ki-24 Antigen，TNLG8A，CD27 Ligand
研究＆開発段階	Phase 2 Clinical

英語名	CD70 antigen
ターゲットの別称	CD70 antigen，Surface Antigen CD70，LPFS3，CD27L，Tumor necrosis factor ligand superfamily member 7，CD27LG，CD27-L，CD70，CD70 Molecule，TNFSF7，Tumor Necrosis Factor (Ligand) Superfamily， Member 7，Tumor Necrosis Factor Ligand 8A，Ki-24 Antigen，TNLG8A，CD27 Ligand
市販薬剤の数	0
治験薬の数	37
研究＆開発段階	Phase 2 Clinical

CD27 Ligand 製品リスト

属性
Protein (14)
製品ライブラリ
オンライン (14)
種
Mouse (3)Human (11)
タグ
Mouse IgG Fc Tag (2)His Tag (6)His Tag & Avi Tag (1)Fc Tag (1)His Tag & Flag Tag (2)His Tag & Avi Tag & Flag Tag (1)Llama IgG Fc Tag (1)
マーカー
Unconjugated (6)Biotin-labeled (2)FITC Labeled (2)APC Labeled (1)PE Labeled (1)AF647 Labeled (1)AF488 Labeled (1)

製品番号	種	発現システム	製品説明
HOT CDD-HF2D4	Human	HEK293	FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
HOT CDL-H5266	Human	HEK293	Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)
HOT CDL-H52Da	Human	HEK293	Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
HOT CDL-H82D7	Human	HEK293	Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™,Flag Tag, active trimer (MALS verified)
CDL-H5255	Human	HEK293	Human CD27 Ligand / CD70 Protein, Llama IgG2b Fc Tag, low endotoxin
CDL-H525a	Human	HEK293	Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-HA246	Human	HEK293	Alexa Fluor™ 647-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA247	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA248	Human	HEK293	APC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HF249	Human	HEK293	FITC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining

総数量14

CD27 Ligandバックグランド

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand分子の別称

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
CD70 VHH - 01	Lead	Monoclonal	Nanobody	Hematological Malignancy	Non-hodgkin lymphoma

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Cusatuzumab	ARGX-110; JNJ-4550	Phase 2 Clinical	Argenx Se	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms	詳細
ARX-305	JNJ-0631; ARX-305; NCB-002	Phase 2 Clinical	Ambrx Inc	Lymphoma; Neoplasms	詳細
CD70.CAR NK cell therapy (Bellicum Pharma)		Phase 2 Clinical	Bellicum Pharmaceuticals Inc, The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphoma, B-Cell	詳細
ADI-270	ADI-270	Phase 2 Clinical	Adicet Bio Inc	Carcinoma, Renal Cell	詳細
CD70 Targeted CAR-T Cells Therapy(UTC Therapeutics)		Phase 2 Clinical	UTC Therapeutics Inc	Lymphoma; Solid tumours; Urologic Neoplasms	詳細
Cord Blood-derived CAR NK Cells Targeting CD19/CD70(Shanghai Tongji Hospital)		Phase 2 Clinical	Shanghai Tongji Hospital	Lymphoma, B-Cell	詳細
MP0533	MP0533	Phase 2 Clinical	Molecular Partners Ag	Leukemia, Myeloid, Acute	詳細
CTX-131	CTX-131	Phase 2 Clinical	Crispr Therapeutics Ag	Carcinoma, Renal Cell; Esophageal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, T-Cell; Mesothelioma; Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms	詳細
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR GD2/CD70	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Neoplasms	詳細
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)		Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Leukemia, B-Cell; Lymphoma, B-Cell	詳細
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR PSMA/CD70	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Neoplasms	詳細
SEA-CD70	SEA-CD70; PF-08046040	Phase 1 Clinical	Seagen Inc	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	詳細
anti-CD70 CAR T-cell therapy linked with modified IL-8 receptor (University of Florida)		Phase 1 Clinical	University Of Florida	Glioblastoma; Glioma; Ovarian Neoplasms; Pancreatic Neoplasms	詳細
CAR BCMA-CD70-T cells therapy (The Fifth Medical Center Of Pla General Hospital)		Phase 1 Clinical	The Fifth Medical Center Of Pla General Hospital (Formerly 307 Hospital)	Neoplasms, Plasma Cell	詳細
Novel CAR-ITNK Cells Targeting CD70 and CLL1 therapy (Tongji Hospital)		Phase 1 Clinical	Tongji Hospital	Leukemia, Myeloid, Acute	詳細
TGFBR-2 KO CD70 CAR NK cell therapy (The University Of Texas MD Anderson Cancer Center)		Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Adenocarcinoma, Clear Cell	詳細
GEN1160	GEN-1160; GEN1160	Phase 1 Clinical	Genmab A/S	Carcinoma, Renal Cell; Lymphoma, Non-Hodgkin; Nasopharyngeal Carcinoma	詳細
CD70-CAR-NK Cell Therapy(Second Affiliated Hospital School Of Zhejiang University School Of Medicine)		Phase 1 Clinical	Second Affiliated Hospital School Of Zhejiang University School Of Medicine	Leukemia, Myeloid, Acute; Lymphoma, T-Cell	詳細
Anti-CD70-CAR-T Cell therapy(First Song Biotechnology)		Phase 1 Clinical	Shanghai First Song Therapeutics Co Ltd	Carcinoma, Renal Cell	詳細
IB-T101		Phase 1 Clinical	Inceptor Bio LLC	Carcinoma, Renal Cell	詳細
Anti-BCMA/CD70 CAR-T cells therapy(The Children'S Hospital, Zhejiang University School Of Medicine)		Phase 1 Clinical	The Children'S Hospital, Zhejiang University School Of Medicine	Lupus Erythematosus, Systemic; Nephrosis	詳細
CD70 UCAR T cells Therapy (Nanjing Calmhome Cell and Gene Engineering Institute)	CHT101; CHT-101	Phase 1 Clinical	Nanjing Calmhome Cell and Gene Engineering Institute Co Ltd	Carcinoma, Renal Cell; Glioma; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	詳細
Chimeric Antigen Recertor Treatment Targeting CD70(Baylor College of Medicine)		Phase 1 Clinical	Baylor College Of Medicine	Bone Marrow Neoplasms; Kidney Neoplasms; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Lymphoma; Sarcoma; Solid tumours	詳細
CAR T-cell Therapy Directed to CD70(St Jude Children's Research Hospital)		Phase 1 Clinical	St. Jude Children'S Research Hospital	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
CD70-targeted CAR-NKT Cells Therapy (CureGenetics)	CGC729; CGC-729	Phase 1 Clinical	Suzhou Cure Genetics Biosciences Co Ltd	Carcinoma, Renal Cell; Solid tumours	詳細
ALLO-329	ALLO-329	Phase 1 Clinical	Allogene Therapeutics Inc	Anti-synthetase Syndrome; Dermatomyositis; Lupus Erythematosus, Systemic; Muscular Diseases; Myositis; Scleroderma, Systemic	詳細
CD70-CART（Hrain）	HR010; HR-010	Phase 1 Clinical	Hrain Biotechnology Co Ltd	Carcinoma, Renal Cell	詳細
Anti-CD19/CD70 NK cell therapy (Zhejiang University)		Phase 1 Clinical	Zhejiang University	Lymphoma, B-Cell	詳細
CD70 CAR-T cell therapy (Chongqing Precision Biotech)		Phase 1 Clinical	Chongqing Precision Biotechnology Co Ltd	Arthritis, Juvenile; Carcinoma, Renal Cell; Dermatomyositis; Genital Neoplasms, Female; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Scleroderma, Systemic; Sjogren's Syndrome; Solid tumours; Thymoma; Thyroid Carcinoma, Anaplastic; Uterine Cervical Neoplasms	詳細
IMM-40H	IMM-40H; IMM40H	Phase 1 Clinical		Hematologic Neoplasms; Neoplasms; Solid tumours	詳細
ALLO-316	ALLO-316	Phase 1 Clinical	Cellectis Sa, Overland Pharmaceuticals (Shanghai) Co Ltd	Carcinoma, Renal Cell; Leukemia, Myeloid, Acute	詳細
CD70 CAR T-cell therapy (Yake Biotechnology)		Phase 1 Clinical	Zhejiang University	Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Multiple Myeloma	詳細
C-4-29		Phase 1 Clinical	Chongqing Precision Biotechnology Co Ltd	Carcinoma, Renal Cell; Lupus Erythematosus, Systemic; Multiple Myeloma	詳細
[68Ga]Ga-NOTA-RCCB6		Clinical	Huashan Hospital	Kidney Neoplasms; Lymphoma	詳細
[18F]RCCB6		Clinical	Huashan Hospital	Kidney Neoplasms	詳細
CGC-738	CGC-738; CGC738	Clinical	Suzhou Cure Genetics Biosciences Co Ltd	Carcinoma, Renal Cell	詳細
CD19/CD70 CAR-NK cells therapy (Rongu Biotechnology)	RG-1970	Clinical	Hangzhou Rongu Biotechnology Co Ltd	Lymphoma, B-Cell; Neoplasms	詳細