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FcRn (FCGRT & B2M)

FcRn (FCGRT & B2M) Overview

English Name	IgG receptor FcRn large subunit p51	Approved Drugs	4
Drugs in Clinical Trials	4	Target Synonym	Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor
Highest Development Stage	Approved

English Name	IgG receptor FcRn large subunit p51
Target Synonym	Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor
Approved Drugs	4
Drugs in Clinical Trials	4
Highest Development Stage	Approved

FcRn (FCGRT & B2M) Product List

Product Category
Protein (22)Cell (2)Kits (1)
Product Status
Launched (25)
Species
Human (9)Cynomolgus / Rhesus macaque (4)Rat (2)Mouse (4)Porcine (1)Feline (1)Rabbit (2)Canine (2)
Tag
His Tag & Strep Tag (6)His Tag & Strep Tag & Avi Tag (3)His Tag & Avi Tag & Strep Tag (1)His Tag & Avi Tag (6)His Tag (5)- (3)Strep Tag (1)
Conjugate
Unconjugated (11)Biotin-labeled (11)- (3)

Cat. No.	Species	Host	Product Description
HOT CHEK-ATP079	Human	HEK293	HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line
HOT FCM-H5283	Human	HEK293	Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified)
HOT FCM-H5286	Human	HEK293	Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, low endotoxin (SPR & HPLC-verified)
HOT FCM-H82W7	Human	HEK293	Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
HOT FCN-H52W7	Human	HEK293	Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & MALS verified)
HOT FCM-C82W9	Canine	HEK293	Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified)
CHEK-ATP132	Human	HEK293	HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line
FCM-H8286	Human	HEK293	Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, ultra sensitivity (primary amine labeling) (HPLC & SPR verified)
FCM-H82W4	Human	HEK293	Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (SPR & HPLC verified)
FRT-01	Human	-	Human FcRn binding Kit (TR-FRET)

Total: 25

FcRn (FCGRT & B2M) Background

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

FcRn (FCGRT & B2M) Synonyms

FcRn,FCGRT & B2M

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
IMVT-1402	IMVT-1402; HL-161 ANS	Phase 3 Clinical	HanAll Biopharma Co Ltd	Arthritis, Rheumatoid; Autoimmune Diseases; Graves Disease; Lupus Erythematosus, Cutaneous; Myasthenia Gravis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome	Details
STSA-1301	STSA-1301; STSA1301	Phase 2 Clinical	Staidson(Beijing) Biopharmaceuticals Co Ltd	Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
ARGX-124	ARGX124; ARGX-124	Phase 1 Clinical	Argenx Se	Immune System Diseases	Details
ARGX-213	ARGX-213	Phase 1 Clinical	Argenx Se	Autoimmune Diseases	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Efgartigimod alfa	EFG PH20 SC; PH20 SC; ARGX-113-2308; ARGX-113; EFG PH20	Approved	Argenx Se	VYVDURA, VYVGART HYTRULO, 卫伟迦, VYVGART	United States	Myasthenia Gravis	Argenx BV	2021-12-17	Epidermolysis Bullosa; Epidermolysis Bullosa Acquisita; Epidermolysis Bullosa Dystrophica; Eye Diseases; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Guillain-Barre Syndrome; Immunoglobulin G4-Related Disease; Lupus Nephritis; Muscular Diseases; Myasthenia Gravis; Myositis; Nephrosis; Nephrotic Syndrome; Optic Neuritis; Pemphigoid, Bullous; Pemphigus; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Postural Orthostatic Tachycardia Syndrome; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Rejection of organ transplantation; Scleroderma, Systemic; Sjogren's Syndrome; Stiff-Person Syndrome; Tachycardia; Thrombocytopenia	Details
Nipocalimab	M-281; JNJ-80202135	Approved	Momenta Pharmaceuticals Inc	IMAAVY	United States	Myasthenia Gravis	Janssen Biotech Inc	2025-04-29	Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Hemolysis; Lupus Erythematosus, Systemic; Lupus Nephritis; Myasthenia Gravis; Myositis; Pemphigoid, Bullous; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Thrombocytopenia, Neonatal Alloimmune	Details
Rozanolixizumab	UCB-7665	Approved	Ucb Sa	RYSTIGGO, 优迪革	United States	Myasthenia Gravis	Ucb Inc	2023-06-27	Encephalitis; Fibromyalgia; Myasthenia Gravis; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic	Details
Efgartigimod alfa/Hyaluronidase		Approved	Argenx BV	VYVDURA, VYVGART HYTRULO	United States	Myasthenia Gravis	Argenx BV	2023-06-20	Anti-synthetase Syndrome; Dermatomyositis; Muscular Diseases; Myasthenia Gravis; Myositis; Polymyositis; Polyradiculoneuropathy; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Details

Product Reviews

I***a2026-04-14
0People Like
Biotinylated Rat FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (MALS & SPR verified)
I purchased rat fcrn from acrobio systems. It was a 25ug powder and I dissolved in my pbs buffer and aliquoted and kept in -20C. I used that fcrn to check the binding kinetics with human igg and assay was successful.FcRn was in high quality
N***i2024-12-24
0People Like
Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified)
I recently used the Biotinylated Rabbit FcRn on the Biacore 8K+ and was highly impressed with its performance. The product worked perfectly as described, delivering reliable and consistent results. It also arrived within the expected time frame, which I greatly appreciated. Overall, I am very satisfied with the quality and service, and I would highly recommend this product to others
C***n2023-05-03
1People Like
Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS verified)
I used Acro's FcRn for development of novel assays. The proteins within just a few days of placing the order. The proteins were also high quality, stable, and did not result in any background in any of the assays that were developed, even after using them for months. These produced great data and we have continued to repurchase them since. I would highly recommend this product.