Recombinant FcRn (FCGRT & B2M) Protein, Cell Line & Kits

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FcRn (FCGRT & B2M) 詳細

Molecule Name

IgG receptor FcRn large subunit p51

分子の別称

FcRn,FCGRT & B2M

Drug Development Progress

治験薬の数4

市販薬剤の数4

研究＆開発段階Approved

ターゲットの別称

Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor

バックグランド

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

FcRn (FCGRT & B2M) 製品リスト

Molecule	Cat. No.	Product Name	種	Host	Purity	Activity	Size&Price
FcRn (FCGRT & B2M)	HOTAvitag FCM-C82W9	Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified)	Canine	HEK293	MALSSDS-PAGE	ELISASPR	$455.00 25ug
FcRn (FCGRT & B2M)	HOT FCN-H52W7	Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISASPRBLI	$360.00 50ug
FcRn (FCGRT & B2M)	HOTAvitag FCM-H82W7	Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)	Human	HEK293	MALSSDS-PAGE	ELISASPRBLI	$470.00 25ug
FcRn (FCGRT & B2M)	HOT FCM-H5283	Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified)	Human	HEK293	MALSSDS-PAGE	SPR	$575.00 50ug
FcRn (FCGRT & B2M)	HOT FCM-H5286	Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, low endotoxin (SPR & HPLC verified)	Human	HEK293	HPLCSDS-PAGE	ELISASPRBLI	$360.00 50ug
FcRn (FCGRT & B2M)	FCM-C5284	Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & MALS verified)	Cynomolgus / Rhesus macaque	HEK293	MALSSDS-PAGE	SPRBLI	$360.00 50ug
FcRn (FCGRT & B2M)	FCM-C52W8	Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)	Canine	HEK293	MALSSDS-PAGE	SPR	$470.00 100ug
FcRn (FCGRT & B2M)	FCM-C52W9	Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & SPR verified)	Cynomolgus / Rhesus macaque	HEK293	MALSSDS-PAGE	SPRBLI	$470.00 50ug
FcRn (FCGRT & B2M)	Avitag FCM-C82W3	Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)	Cynomolgus / Rhesus macaque	HEK293	MALSSDS-PAGE	SPRBLI	$470.00 25ug
FcRn (FCGRT & B2M)	Avitag FCM-C82W5	Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Strep II Tag (HPLC & SPR verified)	Cynomolgus / Rhesus macaque	HEK293	HPLCSDS-PAGE	SPRBLI	$360.00 25ug

FcRn (FCGRT & B2M) >

HotAvitag

Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified)

Cat. No. FCM-C82W9

種

Canine

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$455.00

FcRn (FCGRT & B2M) >

Hot

Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & MALS verified)

Cat. No. FCN-H52W7

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPRBLI

$360.00

FcRn (FCGRT & B2M) >

HotAvitag

Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)

Cat. No. FCM-H82W7

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPRBLI

$470.00

FcRn (FCGRT & B2M) >

Hot

Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified)

Cat. No. FCM-H5283

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPR

$575.00

FcRn (FCGRT & B2M) >

Hot

Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, low endotoxin (SPR & HPLC verified)

Cat. No. FCM-H5286

種

Human

Host

HEK293

Purity

HPLCSDS-PAGE

Activity

ELISASPRBLI

$360.00

FcRn (FCGRT & B2M) >

Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & MALS verified)

Cat. No. FCM-C5284

種

Cynomolgus / Rhesus macaque

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPRBLI

$360.00

FcRn (FCGRT & B2M) >

Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)

Cat. No. FCM-C52W8

種

Canine

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPR

$470.00

FcRn (FCGRT & B2M) >

Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & SPR verified)

Cat. No. FCM-C52W9

種

Cynomolgus / Rhesus macaque

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPRBLI

$470.00

FcRn (FCGRT & B2M) >

Avitag

Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)

Cat. No. FCM-C82W3

種

Cynomolgus / Rhesus macaque

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPRBLI

$470.00

FcRn (FCGRT & B2M) >

Avitag

Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Strep II Tag (HPLC & SPR verified)

Cat. No. FCM-C82W5

種

Cynomolgus / Rhesus macaque

Host

HEK293

Purity

HPLCSDS-PAGE

Activity

SPRBLI

$360.00

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治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
IMVT-1402	IMVT-1402; HL-161 ANS	Phase 3 Clinical	HanAll Biopharma Co Ltd	Arthritis, Rheumatoid; Autoimmune Diseases; Graves Disease; Lupus Erythematosus, Cutaneous; Myasthenia Gravis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome	詳細
STSA-1301	STSA-1301; STSA1301	Phase 2 Clinical	Staidson(Beijing) Biopharmaceuticals Co Ltd	Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	詳細
ARGX-124	ARGX124; ARGX-124	Phase 1 Clinical	Argenx Se	Immune System Diseases	詳細
ARGX-213	ARGX-213	Phase 1 Clinical	Argenx Se	Autoimmune Diseases	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Efgartigimod alfa	EFG PH20 SC; PH20 SC; ARGX-113-2308; ARGX-113; EFG PH20	Approved	Argenx Se	VYVDURA, VYVGART HYTRULO, 卫伟迦, VYVGART	United States	Myasthenia Gravis	Argenx BV	2021-12-17	Epidermolysis Bullosa; Epidermolysis Bullosa Acquisita; Epidermolysis Bullosa Dystrophica; Eye Diseases; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Guillain-Barre Syndrome; Immunoglobulin G4-Related Disease; Lupus Nephritis; Muscular Diseases; Myasthenia Gravis; Myositis; Nephrosis; Nephrotic Syndrome; Optic Neuritis; Pemphigoid, Bullous; Pemphigus; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Postural Orthostatic Tachycardia Syndrome; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Rejection of organ transplantation; Scleroderma, Systemic; Sjogren's Syndrome; Stiff-Person Syndrome; Tachycardia; Thrombocytopenia	詳細
Nipocalimab	M-281; JNJ-80202135	Approved	Momenta Pharmaceuticals Inc	IMAAVY	United States	Myasthenia Gravis	Janssen Biotech Inc	2025-04-29	Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Hemolysis; Lupus Erythematosus, Systemic; Lupus Nephritis; Myasthenia Gravis; Myositis; Pemphigoid, Bullous; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Thrombocytopenia, Neonatal Alloimmune	詳細
Rozanolixizumab	UCB-7665	Approved	Ucb Sa	RYSTIGGO, 优迪革	United States	Myasthenia Gravis	Ucb Inc	2023-06-27	Encephalitis; Fibromyalgia; Myasthenia Gravis; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic	詳細
Efgartigimod alfa/Hyaluronidase		Approved	Argenx BV	VYVDURA, VYVGART HYTRULO	United States	Myasthenia Gravis	Argenx BV	2023-06-20	Anti-synthetase Syndrome; Dermatomyositis; Muscular Diseases; Myasthenia Gravis; Myositis; Polymyositis; Polyradiculoneuropathy; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	詳細

Customer Reviews

I***a2026-04-14
Biotinylated Rat FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (MALS & SPR verified)
I purchased rat fcrn from acrobio systems. It was a 25ug powder and I dissolved in my pbs buffer and aliquoted and kept in -20C. I used that fcrn to check the binding kinetics with human igg and assay was successful.FcRn was in high quality
N***i2024-12-24
Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified)
I recently used the Biotinylated Rabbit FcRn on the Biacore 8K+ and was highly impressed with its performance. The product worked perfectly as described, delivering reliable and consistent results. It also arrived within the expected time frame, which I greatly appreciated. Overall, I am very satisfied with the quality and service, and I would highly recommend this product to others
C***n2023-05-03
Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS verified)
I used Acro's FcRn for development of novel assays. The proteins within just a few days of placing the order. The proteins were also high quality, stable, and did not result in any background in any of the assays that were developed, even after using them for months. These produced great data and we have continued to repurchase them since. I would highly recommend this product.
B***r2022-06-07
Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified)
Protein was received quickly and was high purity confirmed via HPLC, FPLC, SDS-PAGE. Biotinylation label was perfect and confirmed via streptavidin gel shift. Protein was primarily used for ELISA and FACS. Great experimental results so far. Also ordered multiple peptides to determine which domain is the best target. We are hoping to implement the results into our clinical study looking at how targeting the FcRn affects IgG and IgG IC.
1***42019-10-10
Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, low endotoxin (SPR & HPLC verified)
Delivery is fast. The data we obtained from experiments using the antigens has a good reproducibility and consistency. The product information on the official website is also comprehensive. The protocol is also a very good reference. Very nice product.
1***12019-10-12
Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, low endotoxin (SPR & HPLC verified)
I have used the same type of products from different manufacturers. I think ACRO delivers products fast, and the quality is very good. You can always expect a good experimental result. I will continue to support them.
1***32019-10-14
Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & MALS verified)
We used this protein to detect the binding ability of the antibody with FcRn. The instrument we used was Octet Red and the sensor was HIS1K. The binding was very good.
1***22019-10-13
Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & MALS verified)
Recently I purchased this product for affinity test of antibody with FcRn using SPR method. We tested the SEC-HPLC first, and got very high purity. Basically it's one single peak, and well met the requirements for SPR affinity detection.

FcRn (FCGRT & B2M)

FcRn (FCGRT & B2M)

FcRn (FCGRT & B2M) 詳細

FcRn (FCGRT & B2M) 製品リスト

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治験薬に関する情報

市販薬剤に関する情報