Integrin α4β7 Proteins, Cell Lines & ELISA Kits

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Integrin alpha 4 beta 7 詳細

Molecule Name

Integrin alpha-4/beta-7

分子の別称

Integrin alpha 4 beta 7,ITGA4&ITGB7

Drug Development Progress

治験薬の数14

市販薬剤の数4

研究＆開発段階Approved

ターゲットの別称

LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1

バックグランド

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Integrin alpha 4 beta 7 製品リスト

Molecule	Cat. No.	Product Name	種	Host	Purity	Activity	Size&Price
Integrin alpha 4 beta 7	AIDD‑Ready IT7-H52W4AI	Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free	Human	HEK293	MALSSDS-PAGE	SPR	$1540.00 250ug
Integrin alpha 4 beta 7	IT7-C52W4	Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	Cynomolgus	HEK293	MALSSDS-PAGE	ELISASPR	$475.00 100ug
Integrin alpha 4 beta 7	Avitag IT7-C82W3	Biotinylated Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Cynomolgus	HEK293	MALSSDS-PAGE	ELISA	$160.00 25ug
Integrin alpha 4 beta 7	IT7-H52W4	Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (Mass Spec & MALS & SPR verified)	Human	HEK293	MALSSDS-PAGE	ELISASPR	$535.00 100ug
Integrin alpha 4 beta 7	Avitag IT7-H82W4	Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISA	$415.00 25ug

Integrin alpha 4 beta 7 >

AIDD‑Ready

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free

Cat. No. IT7-H52W4AI

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

SPR

$1540.00

Integrin alpha 4 beta 7 >

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cat. No. IT7-C52W4

種

Cynomolgus

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$475.00

Integrin alpha 4 beta 7 >

Avitag

Biotinylated Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT7-C82W3

種

Cynomolgus

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$160.00

Integrin alpha 4 beta 7 >

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (Mass Spec & MALS & SPR verified)

Cat. No. IT7-H52W4

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$535.00

Integrin alpha 4 beta 7 >

Avitag

Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT7-H82W4

種

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$415.00

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FAQ

How should human and cynomolgus α4β7 formats be matched for cross-species comparison?

Use the same heterodimer boundaries and comparable tag or biotinylation formats for both species. Human protein supports immunization and primary screening, while cynomolgus protein evaluates preclinical cross-reactivity.

How should recombinant α4β7 protein and an α4β7 stable cell line be sequenced in screening?

Use recombinant α4β7 for affinity ranking and biochemical inhibition, then confirm hits on the stable cell line. This step identifies candidates affected by membrane presentation, accessibility, or avidity.

When should I use the α4β7/MAdCAM-1 ELISA kit or the TR-FRET kit?

ELISA is useful for plate-based inhibition studies and straightforward endpoint detection. TR-FRET provides a homogeneous, no-wash format better suited to higher-throughput screening and automation.

How do integrin activation conditions affect α4β7–MAdCAM-1 binding results?

Divalent cations and chelators can shift α4β7 conformation and apparent affinity. Keep Ca²⁺, Mg²⁺, Mn²⁺, and EDTA conditions consistent when comparing candidates or transferring an assay.

How can α4β7-specific binders be distinguished from antibodies that also recognize α4β1 or α4β7?

Screen on assembled α4β7, then counter-screen against integrins sharing the α4 or β7 subunit. Confirm final hits on an α4β7 stable cell line to assess specificity in a membrane context.

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Resources

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Etrolizumab	PRO-145223; rhuMAb-Beta7; R-7413; RG-7413	Phase 3 Clinical	Genentech Inc	Colitis, Ulcerative; Crohn Disease	詳細
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	詳細
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	詳細
Natalizumab biosimilar (GENERIUM Pharmaceuticals)	GNR-093	Phase 3 Clinical	Generium Pharmaceuticals	Multiple Sclerosis	詳細
LY-4268989	MORF-057; LY-4268989; LY4268989	Phase 2 Clinical	Morphic Therapeutic Inc	Colitis, Ulcerative; Crohn Disease	詳細
EA-1080	EA-1080; NSHO-101	Phase 2 Clinical	Ea Pharma	Colitis, Ulcerative; Crohn Disease; Inflammatory Bowel Diseases	詳細
PN-10943	PN-10943-A; PN-10943; PN-943	Phase 2 Clinical	Protagonist Therapeutics Inc	Colitis, Ulcerative	詳細
Emvistegrast	GS-1427	Phase 2 Clinical	Gilead Sciences Sl	Colitis, Ulcerative; Inflammatory Bowel Diseases	詳細
ABBV-466		Phase 2 Clinical	Abbvie Inc	Crohn Disease	詳細
SPY-001	SPY001; SPY-001; PR-011; PR011; SPY001-001	Phase 2 Clinical	Paragon Therapeutics Inc	Colitis; Colitis, Ulcerative; Inflammatory Bowel Diseases	詳細
Trosunilimab	ABBV-382	Phase 2 Clinical	Abbvie Inc	Crohn Disease; HIV Infections	詳細
PTG-100	PTG-100	Phase 1 Clinical	Protagonist Therapeutics Inc	Celiac Disease; Colitis, Ulcerative	詳細
NSHO-102	NSHO-102	Phase 1 Clinical	Ensho Therapeutics Inc	Inflammatory Bowel Diseases	詳細
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Carotegrast methyl	AJM-300	Approved	Ea Pharma, Eisai Co Ltd	Carogra	Japan	Colitis, Ulcerative	Ea Pharma Co Ltd	2022-03-28	Colitis, Ulcerative	詳細
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	詳細
Natalizumab biosimilar (Polpharma Biologics)	PB-006; DST-356A1	Approved	Polpharma Biologics Sa	Tyruko	United States	Multiple Sclerosis; Crohn Disease	Sandoz Inc	2023-08-24	Crohn Disease; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting	詳細
Natalizumab	BG-0002; TY-21.6; AN-10022; BG-00002; AN-100226; BG-0002-E	Approved	Biogen Inc, Perrigo Llc	Tysabri, Antegran, Antegren	United States	Crohn Disease; Multiple Sclerosis	Biogen Idec	2004-11-23	Arthritis, Rheumatoid; Crohn Disease; Demyelinating Diseases; Epilepsies, Partial; Graft vs Host Disease; Ischemic Stroke; Multiple Myeloma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myositis, Inclusion Body	詳細

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Integrin alpha 4 beta 7

Integrin alpha 4 beta 7

Integrin alpha 4 beta 7 詳細

Integrin alpha 4 beta 7 製品リスト

Can’t find what you need?

How should human and cynomolgus α4β7 formats be matched for cross-species comparison?

How should recombinant α4β7 protein and an α4β7 stable cell line be sequenced in screening?

When should I use the α4β7/MAdCAM-1 ELISA kit or the TR-FRET kit?

How do integrin activation conditions affect α4β7–MAdCAM-1 binding results?

How can α4β7-specific binders be distinguished from antibodies that also recognize α4β1 or α4β7?

治験薬に関する情報

市販薬剤に関する情報