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Siglec-15

Siglec-15 詳細

英語名	Sialic acid-binding Ig-like lectin 15	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
研究＆開発段階	Phase 2 Clinical

英語名	Sialic acid-binding Ig-like lectin 15
ターゲットの別称	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

Siglec-15 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Human (4)Rhesus macaque (1)Mouse (1)Rat (1)
タグ
Fc Tag (1)His Tag (4)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (5)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT SG5-H5253	Human	HEK293	Human Siglec-15 / CD33L3 Protein, Fc Tag
HOT SG5-H52H3	Human	HEK293	Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
HOT SG5-H82E9	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)
HOT SG5-H82F5	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™
SG5-M52H7	Mouse	HEK293	Mouse Siglec-15 / CD33L3 Protein, His Tag
SG5-C52H6	Rhesus macaque	HEK293	Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag
SG5-R52H3	Rat	HEK293	Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)

総数量7

Siglec-15バックグランド

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15分子の別称

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
NC-318	NC-318; 5G-12	Phase 2 Clinical	Yale School Of Medicine	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Lung Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
DS-1501	DS-1501	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	詳細
BSI-060T	PYX-106; BSI-060T	Phase 1 Clinical	Biosion Inc	Neoplasm Metastasis; Solid tumours	詳細

レビュー

1***22019-10-11
6評価
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.
1***32019-10-11
1評価
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
1***22019-10-12
8評価
Human Siglec-15 / CD33L3 Protein, Fc Tag
We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.