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TPBG

TPBG 詳細

英語名	Trophoblast glycoprotein	市販薬剤の数	0
治験薬の数	16	ターゲットの別称	Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG
研究＆開発段階	Phase 2 Clinical

英語名	Trophoblast glycoprotein
ターゲットの別称	Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG
市販薬剤の数	0
治験薬の数	16
研究＆開発段階	Phase 2 Clinical

TPBG 製品リスト

属性
Protein (9)Cell (1)Antibody (1)
製品ライブラリ
オンライン (10)研究中 (1)
種
Human (6)Cynomolgus / Rhesus macaque (1)Mouse (2)Rat (1)Rabbit (1)
タグ
His Tag & Avi Tag (2)Fc Tag (2)His Tag (4)Fc Tag & Avi Tag (1)- (2)
マーカー
Biotin-labeled (2)Unconjugated (8)- (1)

製品番号	種	発現システム	製品説明
HOT TPG-H52E5	Human	HEK293	Unconjugated Human TPBG / 5T4 Protein, His,Avitag™ (MALS verified)
HOT TPG-H82Eb	Human	HEK293	Biotinylated Human TPBG / 5T4 Protein, His,Avitag™
HOT TPG-M52H3	Mouse	HEK293	Mouse TPBG / 5T4 Protein, His Tag (MALS verified)
HOT TPG-C52H3	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His Tag
CHEK-ATP176	Human	HEK293	HEK293/Human TPBG Stable Cell Line
TPG-H5253	Human	HEK293	Human TPBG / 5T4 Protein, Fc Tag (MALS verified)
TPG-H52H3	Human	HEK293	Human TPBG / 5T4 Protein, His Tag (MALS verified)
TPG-H82F6	Human	HEK293	Biotinylated Human TPBG / 5T4 protein, Fc,Avitag™ (MALS verified)
TPG-M5255	Mouse	HEK293	Mouse TPBG / 5T4 Protein, Fc Tag (MALS verified)
HGS-M2717	Rabbit	-	Recombinant Monoclonal Anti-TPBG Antibody, Rabbit (P1B10)

総数量11

TPBGバックグランド

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

TPBG分子の別称

TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
5T4 mAb - 01	Lead	Monoclonal	Humanized Mouse	Solid Tumor	Ovarian cancer,Lung cancer

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Naptumomab estafenatox	TTS-CD3; ABR-217620	Phase 2 Clinical	Active Biotech Ab	Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
ALG.APV-527	ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527	Phase 2 Clinical	Alligator Bioscience Ab, Aptevo Therapeutics Inc	Neoplasms; Solid tumours	詳細
JK-06	JK-06	Phase 2 Clinical	Xinlitai (Chengdu) Biological Technology Co Ltd	Neoplasms; Solid tumours	詳細
TUB-030	TUB-030	Phase 2 Clinical	Tubulis GmbH	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
ACR-246	ACR246; ACR-246; ADC2154; ADC-2154	Phase 2 Clinical	Hangzhou Adcoris Biopharmacy Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms	詳細
IBR-854	IBR854; IBR-854	Phase 2 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Solid tumours	詳細
SYD-1875	SYD-1875	Phase 1 Clinical	Synthon Bv	Solid tumours	詳細
ASN-004	ASN-004	Phase 1 Clinical	Asana Biosciences Llc	Solid tumours	詳細
anti-5T4 CAR NK-cell therapy (Wuxi Peapole's Hospital/Hangzhou Yingbairui Biomedical Technology)		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	詳細
Naptumomab estafenatox/Durvalumab	NTX-352	Phase 1 Clinical	Neotx Therapeutics Ltd	Solid tumours	詳細
XB-010	XB-010	Phase 1 Clinical	Exelixis Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
FTL-008.16	FTL-008.16; FTL008.16	Phase 1 Clinical	Sound(Chengdu)Biopharmacauticals Co Ltd	Solid tumours	詳細
CBA-1535	CBA-1535	Phase 1 Clinical	Chiome Bioscience Inc	Carcinoma, Non-Small-Cell Lung; Mesothelioma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms	詳細
Anti-5T4 CAR-raNK Cell Therapy		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	詳細
Prostate cancer vaccine(inactivated viral)(University of Oxford)		Clinical	University Of Oxford	Prostatic Neoplasms	詳細
68Ga-NOTA-H006		Clinical	Huashan Hospital	Solid tumours	詳細