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The B.1.617 is Likely Behind the Recent Surge of COVID-19 Cases in India On April 22nd, India reported 314,835 new COVID-19 cases — a single-day world record. As the recent surge of cases in this country captured global attention, sequence sampling shows that new viral variants are likely behind the worrying situation.
The B.1.617 variant (aka double mutant) is characterized by two mutations, E484Q and L452R, known to be associated with increased infectivity and immune escape. These two mutations have been separately identified on other SARS-CoV-2 strains, but their coexistence on the same virus is unprecedented and highly concerning. First identified in Oct. 2020, this variant is reported to be responsible for the deadly spread of cases in Maharashtra and other states this month.
Another variant found to be circulating in Bengal, B.1.618 (aka triple mutant), is suspected to have evolved from existing double mutations and contains V382L in its spike in addition to E484Q and L452R. One thing to clarify though is that the name “double mutant” and “triple mutant” are not exactly appropriate, as these new strains have many more defining mutations on the spike protein.
According to GISAID Database, B.1.617 has been spotted in 18 countries over the world. In face of the new threats, researchers are yet to establish the link between the mutations, clinical outcomes and vaccine efficacy. India has approved 3 vaccines as part of its ongoing vaccination program: Covaxin developed by Bharat Biotech; Covishield developed by Oxford-Astrazeneca; and the recently approved Russian made Sputnik V vaccine. So far, there are encouraging but very preliminary result that Covishield vaccines offer protection against the double mutant variant.
To support research into the solution to the new variant, ACROBiosystems has incorporated the development of recombinant double mutant antigens into our pipeline. See below to preorder:
India variant
S.A. variant
UK variant
Brazil variant
California variant
other S & N mutants
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
Spike RBD | SPD-C52Hv | His Tag | HEK293 | SARS-CoV-2 Spike RBD (L452R, E484Q), His Tag | B.1.617 | |
Spike RBD | SPD-C82Ec | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 Spike RBD (L452R, E484Q), His,Avitag™ | B.1.617 | |
Spike S1 | S1N-C52Ht | His Tag | HEK293 | SARS-CoV-2 Spike S1 (T95I, G142D, E154K, L452R, E484Q, D614G, P681R), His Tag | B.1.617 | |
Spike S1 | S1N-C82E4 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 Spike S1 (T95I, G142D, E154K, L452R, E484Q, D614G, P681R), His,Avitag™ | B.1.617 | |
Spike protein | SPN-C52Hr | His Tag | HEK293 | SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His Tag | B.1.617 | |
Spike protein | SPN-C82E7 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His,Avitag™ | B.1.617 | |
Spike NTD | S1D-C52Hf | His Tag | HEK293 | SARS-CoV-2 Spike NTD (T95I, G142D, E154K), His Tag | B.1.617 | |
Nucleocapsid protein | NUN-C52Hn | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (R203M, D377Y), His Tag | B.1.617 |
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
S protein | SPN-C52H3 | His Tag | HEK293 | SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C52Hk | His Tag | HEK293 | SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His Tag (MALS verified) | B.1.351 | |
S protein | SPN-C82E4 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His,Avitag™ (MALS verified) | B.1.351 | |
S1 protein | S1N-C5256 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1N-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™ | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1N-C52Hm | His Tag | HEK293 | SARS-CoV-2 S1 protein (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G), His Tag | B.1.351 | |
S1 protein | S1D-C5256 | Fc Tag | HEK293 | SARS-CoV-2 S1 protein (L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G), Fc Tag | B.1.351 | |
S1 protein | S1N-C52Hn | His Tag | HEK293 | SARS-CoV-2 S1 protein (E484K, D614G), His Tag | B.1.351/P.1 | |
S1 protein NTD | S1D-C52Hc | His Tag | HEK293 | SARS-CoV-2 S1 protein NTD (L18F, D80A, D215G, 242-244del, R246I), His Tag (MALS verified) | B.1.351 | |
S protein RBD | SPD-C52Hs | His Tag | HEK293 | SARS-CoV-2 S protein RBD (K417N), His Tag (MALS verified) | B.1.351 | |
S protein RBD | SRD-C52H3 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (E484K), His Tag (MALS verified) | B.1.351 | |
S protein RBD | SPD-C52Hp | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (K417N, E484K, N501Y), His Tag (MALS verified) | B.1.351 | |
S protein RBD | SPD-C5256 | Fc Tag | HEK293 | SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), Fc Tag (MALS verified) | B.1.351 | |
S protein RBD | SPD-C82E5 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), His,Avitag™ | B.1.351 | |
S2 protein | S2N-C52Hc | His Tag | HEK293 | SARS-CoV-2 S2 protein (A701V), His Tag | B.1.351 | |
Nucleocapsid protein | NUN-C52Hd | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (T205I), His Tag | B.1.351 |
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
S protein | SPN-C52H3 | His Tag | HEK293 | SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C52H6 | His Tag | HEK293 | SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (MALS verified) | B.1.1.7 | |
S protein | SPN-C82E5 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitag™ (MALS verified) | B.1.1.7 | |
S1 protein | S1N-C52Hd | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (HV69-70del), His Tag | B.1.1.7 | |
S1 protein | S1N-C52Hc | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (Y144del), His Tag | B.1.1.7 | |
S1 protein | S1N-C52Hb | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (P681H), His Tag | B.1.1.7 | |
S1 protein | S1N-C52Hk | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (HV69-70del, N501Y, D614G), His Tag | B.1.1.7 | |
S1 protein | S1N-C52Hr | His Tag | HEK293 | SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), His Tag | B.1.1.7 | |
S1 protein | S1N-C52Hg | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag | B.1.1.7/B.1.351 | |
S1 protein | S1N-C52H9 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (A570D), His Tag | B.1.1.7 | |
S1 protein | S1N-C5256 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1N-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™ | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1D-C5254 | Fc Tag | HEK293 | SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), Fc Tag | B.1.1.7 | |
S1 protein NTD | S1D-C52Hd | His Tag | HEK293 | SARS-CoV-2 S1 protein NTD (HV69-70del, Y144del), His Tag (MALS verified) | B.1.1.7 | |
S protein RBD | SPD-C82E6 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein RBD (N501Y), His,Avitag™ (MALS verified) | B.1.1.7 | |
S protein RBD | SPD-C52Hn | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (N501Y), His Tag (MALS verified) | B.1.1.7/B.1.351 | |
S protein RBD | SPD-C5253 | Fc Tag | HEK293 | SARS-CoV-2 S protein RBD (N501Y), Fc Tag (MALS verified) | B.1.1.7 | |
S2 protein | S2N-C52Hd | His Tag | HEK293 | SARS-CoV-2 S2 protein (T716I, S982A, D1118H), His Tag | B.1.1.7 | |
Nucleocapsid protein | NUN-C52H8 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (D3L, R203K, G204R, S235F), His Tag | B.1.1.7 |
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
S protein | SPN-C52H3 | His Tag | HEK293 | SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified) | B.1.1.7/B.1.351/P.1 | |
S protein | SPN-C52Hg | His Tag | HEK293 | SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified) | P.1 | |
S protein | SPN-C82E6 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) trimer, His,Avitag™ (MALS verified) | P.1 | |
S1 protein | S1N-C5256 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1N-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™ | B.1.1.7/B.1.351/P.1 | |
S1 protein | S1D-C5253 | Fc Tag | HEK293 | SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), Fc Tag | P.1 | |
S1 protein | S1N-C52Hp | His Tag | HEK293 | SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), His Tag | P.1 | |
S1 protein NTD | S1D-C52He | His Tag | HEK293 | SARS-CoV-2 S1 protein NTD (L18F, T20N, P26S, D138Y, R190S), His Tag (MALS verified) | P.1 | |
S protein RBD | SPD-C52Ht | His Tag | HEK293 | SARS-CoV-2 S protein RBD (K417T), His Tag (MALS verified) | P.1 | |
S protein RBD | SPD-C52Hr | His Tag | HEK293 | SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His Tag (MALS verified) | P.1 | |
S protein RBD | SPD-C82E7 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His,Avitag™ | P.1 | |
S protein RBD | SPD-C5258 | Fc Tag | HEK293 | SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), Fc Tag (MALS verified) | P.1 | |
S2 protein | S2N-C52He | His Tag | HEK293 | SARS-CoV-2 S2 protein (T1027I, V1176F), His Tag | P.1 |
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
S1 protein | S1N-C52Hs | His Tag | HEK293 | SARS-CoV-2 S1 protein (W152C, L452R, D614G), His Tag | B.1.427/B.1.429 | |
S protein RBD | SPD-C52He | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (L452R), His Tag | B.1.427/B.1.429 | |
Spike RBD | SPD-C82E3 | His Tag & Avi Tag | HEK293 | Biotinylated SARS-CoV-2 S protein RBD (L452R), His,Avitag™ | B.1.427/B.1.429 |
Molecule | Cat.No. | Tag | Host | Product description | Species | Preorder/Order |
---|---|---|---|---|---|---|
Nucleocapsid protein | NUN-C52Hm | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (P13L), His Tag | ||
Nucleocapsid protein | NUN-C52Hc | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (P80R), His Tag | P.1 | |
Nucleocapsid protein | NUN-C52H5 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (D103Y), His Tag | ||
Nucleocapsid protein | NUN-C52He | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (S194L), His Tag | ||
Nucleocapsid protein | NUN-C52H6 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (S197L), His Tag | ||
Nucleocapsid protein | NUN-C52H3 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (S202N), His Tag | ||
Nucleocapsid protein | NUN-C52H9 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (L230F), His Tag | ||
Nucleocapsid protein | NUN-C52Hf | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (I292T), His Tag | ||
Nucleocapsid protein | NUN-C52H4 | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (Q384H), His Tag | ||
Nucleocapsid protein | NUN-C52Hg | His Tag | HEK293 | SARS-CoV-2 Nucleocapsid protein (R203K, G204R), His Tag | ||
S protein | SPN-C52Hd | His Tag | HEK293 | SARS-CoV-2 S protein (F817P, A892P, A899P, A942P, K986P, V987P), His Tag (MALS verified) | ||
S1 protein NTD | S1D-C52H8 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein NTD (A222V), His Tag (MALS verified) | ||
S1 protein NTD | S1D-C52H7 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein NTD (N234Q), His Tag | ||
S1 protein NTD | S1D-C52H5 | His Tag | HEK293 | SARS-CoV-2 S1 protein NTD (A262S), His Tag (MALS verified) | ||
S1 protein NTD | S1D-C52H4 | His Tag | HEK293 | SARS-CoV-2 S1 protein NTD (P272L), His Tag (MALS verified) | ||
S protein RBD | SPD-S52H5 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag | ||
S protein RBD | SPD-S52H4 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag | ||
S protein RBD | SPD-S52H8 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag | ||
S protein RBD | SPD-S52H7 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag | ||
S protein RBD | SPD-C52Hg | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (N439K), His Tag (MALS verified) | ||
S protein RBD | SRD-C52H2 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (N440K), His Tag (MALS verified) | ||
S protein RBD | SPD-C52Hk | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (Y453F), His Tag (MALS verified) | ||
S protein RBD | SPD-C52Hd | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (A475V), His Tag | ||
S protein RBD | SPD-C52H4 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag | ||
S protein RBD | SPD-C52Hm | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (S477N), His Tag (MALS verified) | ||
S protein RBD | SPD-C52H5 | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag | ||
S protein RBD | SPD-C52Hf | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S protein RBD (F490L), His Tag | ||
S1 protein | S1N-C52Hf | His Tag | HEK293 | SARS-CoV-2 (COVID-19) S1 protein (E583D), His Tag |
>>> If you have any customized inquiries or suggestions for new mutants, please click here.
Reference:
3 Sputnik V, Covishield, Covaxin: What we know about India's Covid-19 vaccines - BBC News
5 Covid-19: India authorises Sputnik V vaccine as cases soar to more than 180 000 a day | The BMJ
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