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Your Position: ホーム > DLL3

DLL3

概要

Name:Delta-like protein 3
Target Synonym:Delta-Like Protein 3,Delta3,Delta-Like 3,Drosophila Delta Homolog 3,SCDO1,Delta-Like 3 (Drosophila),DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
DLL3 mAb - 01 Lead Solid Tumor Small cell lung cancer

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製造番号 種類 製品説明 構造 純度 特徴
CEA-B049 Human ClinMax™ Human DLL3 ELISA Kit
MBS-C018 Human ActiveMax® Human DLL3 μBeads, premium grade (for cells)
SCCHO-ATP111 Human CHO/Human DLL3 Stable Cell Line
DL3-HA2H3 Human Alexa Fluor™ 647-Labeled Human DLL3 Protein, His TagStar Staining
DL3-HA2H8 Human APC-Labeled Human DLL3 Protein, His TagStar Staining
CHEK-ATP090 Human HEK293/Human DLL3 Stable Cell Line
DL3-HP2H7 Human PE-Labeled Human DLL3 Protein, His Tag (Site-specific conjugation)
DL3-HP2H7-structure
DL3-H525x Human Human DLL3 Protein, Llama IgG2b Fc Tag
DL3-H525x-structure
DL3-H525x-sds
DL3-C82E9 Cynomolgus Biotinylated Cynomolgus DLL3 Protein, His,Avitag™
DL3-C82E9-structure
DL3-C82E9-sds
DL3-C52H9 Cynomolgus Cynomolgus DLL3 (27-488) Protein, His Tag
DL3-C52H9-structure
DL3-C52H9-sds
DL3-M52H9 Mouse Mouse DLL3 Protein, His Tag (HPLC verified)
DL3-M52H9-sds
DL3-M52H9-hplc
DL3-H52Hy Human Human DLL3 (176-492) Protein, His Tag
DL3-H52Hy-structure
DL3-H52Hy-sds
DL3-H52Hz Human Human DLL3 (312-492) Protein, His Tag
DL3-H52Hz-structure
DL3-H52Hz-sds
DL3-H52Ha Human Human DLL3 (353-492) Protein, His Tag
DL3-H52Ha-structure
DL3-H52Ha-sds
DL3-H82E4 Human Biotinylated Human DLL3 Protein, His,Avitag™ (MALS verified)
DL3-H82E4-structure
DL3-H82E4-sds
DL3-R52H4 Rhesus macaque Rhesus macaque DLL3 Protein, His Tag
DL3-R52H4-structure
DL3-R52H4-sds
DL3-R52H3 Rat Rat DLL3 Protein, His Tag
DL3-R52H3-structure
DL3-R52H3-sds
DL3-HF2H4 Human FITC-Labeled Human DLL3 Protein, His Tag
DL3-HF2H4-structure
DL3-HF2H4-sds
DL3-C52H3 Cynomolgus Cynomolgus DLL3 Protein, His Tag (MALS verified)
DL3-C52H3-structure
DL3-C52H3-sds
DL3-H52H4 Human Human DLL3 Protein, His Tag (MALS verified)
DL3-H52H4-structure
DL3-H52H4-sds
ACRO Quality

生物活性データの一部

MBS-C018-Cell-based assay
DLL3 FACS

Assay of human DLL3 protein on the μBeads surface by Flow cytometry. The human DLL3 protein conjugated on the μBeads (Cat. No. MBS-C018) surface were fluorescently stained using anti-human DLL3 antibody and PE anti-human IgG Fc Recombinant Antibody, and then analyzed by flow cytometry.

Protocol
SCCHO-ATP111-Cell-based assay
DLL3 FACS

Expression analysis of human DLL3 on CHO/Human DLL3 Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human DLL3 Stable Cell Line or negative control cell using anti-human DLL3 antibody followed by staining with PE anti-human IgG Fc Antibody.

Protocol
DL3-C52H9-SPR
DLL3 SPR

Bispecific T-cell Engager captured on Protein A Chip can bind Cynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) with an affinity constant of 1.02 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
DL3-M52H9-SPR
DLL3 SPR

Bispecific T-cell Engager captured on Protein A Chip can bind Mouse DLL3, His Tag (Cat. No. DL3-M52H9) with an affinity constant of 1.13 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tarlatamab AMG-757 Approved Amgen Inc Imdelltra United States Small Cell Lung Carcinoma Amgen Inc 2024-05-16 Small Cell Lung Carcinoma; Neoplasms; Oligodendroglioma; Prostatic Neoplasms; Astrocytoma Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
MK-6070 HPN-328; MK-6070 Phase 2 Clinical Harpoon Therapeutics Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
Obrixtamig BI-764532; OBT620 Phase 2 Clinical C.H. Boehringer Sohn Ag & Co. Kg Small Cell Lung Carcinoma; Neoplasms; Neuroendocrine Tumors; Carcinoma, Neuroendocrine; Glioma Details
PT-217 PT-217 Phase 2 Clinical Phanes Therapeutics Inc Solid tumours; Small Cell Lung Carcinoma; Prostatic Neoplasms; Carcinoma, Neuroendocrine Details
ZG006 ZG006; ZG-006 Phase 2 Clinical Gensun Biopharma Inc, Suzhou Zelgen Biopharmaceuticals Co Ltd Solid tumours; Small Cell Lung Carcinoma; Neoplasms; Carcinoma, Neuroendocrine Details
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
IBI-3009 IBI3009; IBI-3009 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
ALPS-12 ALPS12; RG6524; RG-6524; ALPS 12 Phase 1 Clinical Chugai Pharmaceutical Co Ltd Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
BHP-01 BHP-01; BHP01; α-PD-L1/4-1BB DLL3 CAR-T Phase 1 Clinical Chengdu Brilliant Pharmaceutical Co Ltd Small Cell Lung Carcinoma Details
SHR-4849 SHR-4849; SHR4849 Phase 1 Clinical Jiangsu Hengrui Pharmaceutical Group Co Ltd Solid tumours Details
ZL-1310 ZL-1310; ZL1310; YL212; YL-212 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd, MediLink Therapeutics Co Ltd Solid tumours; Small Cell Lung Carcinoma Details
FZ-AD005 FZAD005; FZ-AD005 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours; Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
[89Zr]Zr-BI-764532 Phase 1 Clinical C.H. Boehringer Sohn Ag & Co. Kg, Boehringer Ingelheim Gmbh Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
ABD-147 ABD-147; 225Ac-ABD147 Phase 1 Clinical Abdera Therapeutics Inc Solid tumours; Small Cell Lung Carcinoma; Neuroendocrine Tumors Details
SNC115 SNC115; SNC-115 Phase 1 Clinical Shanghai Simnova Biotechnology Co Ltd Solid tumours; Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
OBT620 OBT620 Phase 1 Clinical Boehringer Ingelheim Gmbh, Oxford Biotherapeutics Ltd Small Cell Lung Carcinoma Details
DLL3-CAR-NK cells Therapy(Tianjin Medical University Cancer Institute and Hospital) DLL3-CAR-NK cells Phase 1 Clinical Tianjin Medical University Cancer Institute And Hospital Small Cell Lung Carcinoma Details
QLS-31904 QLS31904; QLS-31904 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
LB-2102(Legend Biotechnology) LB-2102 Phase 1 Clinical Nanjing Legend Biotechnology Co Ltd Small Cell Lung Carcinoma; Neuroendocrine Tumors Details

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