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VEGFタンパク質:腫瘍の供給を阻害する
血管内皮細胞増殖因子(VEGF)は、血管新生と再生を促進するほか、免疫調節や神経保護などの役割を持っています。VEGFファミリーは、VEGF受容体ファミリーに属する3つの受容体との相互作用を通じて効果を発揮しています。VEGFは、多くの腫瘍において過剰発現するとアップレギュレーションされます。このように、腫瘍治療薬の創薬のターゲットとして注目を受けています。
現在、VEGFに対するモノクローナル抗体(mAb)や二重特異性抗体(BsAb)など、100種類以上の抗体薬が臨床治療に広く使用されています。
VEGFは腫瘍、眼内新生血管障害、その他の心血管疾患を含む複数の種類の癌の治療における重要な役割を果たしていると考えられ、VEGFを新しい標的とした治療薬の開発が進められています。
弊社は抗体医薬品の開発を促進するために、様々な分子、サブタイプ、生物種、タグを備えたVEGFタンパク質の開発に成功しています。すべてのSPR&BLIプロトコルは無償で提供しております。
VEGF-A
VEGF-B
VEGF-C
VEGF-D
VEGF R1
VEGF R2
VEGF R3
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>>>VEGFについてご質問のある方は弊社までご連絡ください。 contact us.
The purity of ActiveMax® Human VEGF165, Tag Free (MALS verified) (Cat. No. VE5-H4210) is more than 95% in HP-SEC, and the molecular weight of this protein is around 40-55 kDa verified by SEC-MALS.
Immobilized Human VEGF R1&VEGF R2, Fc Tag at 2 μg/mL (100 μL/well) can bind Human VEGF165, His Tag (Cat. No. VE5-H5248) with a linear range of 0.004-0.063 μg/mL (QC tested).
Immobilized Biotinylated Human VEGF165, His,Avitag (Cat. No. VE5-H82Q0) on CM5 Chip via Streptavidin, can bind Avastin with an affinity constant of 0.417 nM as determined in SPR assay (Biacore T200) (Routinely tested).
Loaded Avastin (Bevaciz*mab) on AHC Biosensor, can bind Human VEGF165, His Tag (Cat. No. VE5-H5248) with an affinity constant of 0.448 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
ActiveMax® Human VEGF165, Tag Free (MALS verified) (Cat. No. VE5-H4210) stimulates proliferation of human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is 4.216-9.281 ng/mL (Routinely tested).
Inhibition assay shows that the proliferation effect of ActiveMax® Human VEGF165, Tag Free (MALS verified) (Cat. No. VE5-H4210) is inhibited by increasing concentration of anti-VEGF mAb (Avastin). The concentration of VEGF165 used is 20 ng/mL. The ED50 is 0.065-0.229 μg/mL (Routinely tested).
CHLOROTOXIN AGENTS AND USES THEREOF
Authors: Mcgonigle Sharon,Majumder Utpal,Postema Maarten H. D.
Cited Product: VE5-H4210
Journal: US20200206312A1 2020
Application: Binding Assay
CHLOROTOXIN AGENTS AND USES THEREOF
Authors: Mcgonigle Sharon,Majumder Utpal,Postema Maarten H. D.
Cited Product: VE5-H8210
Journal: US20200206312A1 2020
Application: Binding Assay
FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK
Authors: Chen PC, Hsueh YW, Lee YH, et al.
Cited Product: VE5-H4210
Journal: Cell Mol Life Sci 2020
Application: Flow cytometry
Authors: Meng Wang, Youke Qi, Yongning Sun
Cited Product: VE5-H5248
Journal: BioMed Research International 2020
Application: SPR
Biophysical characterization platform informs protein scaffold evolvability
Authors: Golinski AW, et al
Cited Product: VE1-H82E7
Journal: ACS COMB SCI 2019
Application: Binding Assay
Authors: F Corti, et al
Cited Product: VE5-H8210
Journal: Nat Commun 2019
Application: ELISA
Neuropilin-1 drives tumor-specific uptake of chlorotoxin
Authors: McGonigle S, et al
Cited Product: VE5-H8210
Journal: Cell Commun Signal 2019
Application: BLI
Methods of producing glycosylated proteins
Authors: ML Wetter, et al
Cited Product: VE5-H4210
Journal: US20180354997A1 2018
Application: SPR
Neuropilin-1 mediates Neutrophil Elastase uptake and cross-presentation in breast cancer cells
Authors: Kerros C, et al.
Cited Product: VE5-H5248
Journal: J Biol Chem 2017
Application: BLI
A biosynthetic route for polysialylating proteins in Escherichia coli
Authors: Keys TG, et al.
Cited Product: VE5-H4210
Journal: Metab Eng 2017
Application: SPR
In vitro Fab display: a cell-free system for IgG discovery
Authors: Stafford RL, et al.
Cited Product: VE1-H4213
Journal: Protein Eng Des Sel 2014
Application: SPR(Biacore T200)
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