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> MHCクラスI 複合体カスタムサービス
プロフェッショナルなMHC-ペプチド複合体の研究開発技術プラットフォーム
HEK293 発現系
さまざまなMHC I と抗原が利用可能
FITC/PE/APC/ビオチン標識を選択可能
成熟した生物活性検証プラットフォーム: SPR/ELISA/FACS など
| MHC Allele | |||||||
|---|---|---|---|---|---|---|---|
| Human classical MHC class I | Human classical MHC II | Mouse | Monkey | ||||
| HLA-A*01:01HLA-A*02:01HLA-A*02:06HLA-A*03:01HLA-A*11:01HLA-A*24:02HLA-A*26:01HLA-A*30:01HLA-A*33:03 | HLA-B*07:02HLA-B*08:01HLA-B*15:01HLA-B*15:02HLA-B*27:05HLA-B*40:01 | HLA-C*03:03HLA-C*03:04HLA-C*07:02:01HLA-C*08:01 | HLA-E*01:03 | HLA-DQA1*03:02 &DQB1*03:03 HLA-DRA1*01:01 &HLA-DRB1*04:01 HLA-DRA1*01:01 &HLA-DRB1*11:01 HLA-DRA1*01:01 &HLA-DRB1*15:01 | H-2DbH-2KbH-2KdIgG2b (BBM.1) | Mamu-A*01Mamu-A*08 | New alleles are always in development. If you do not see your allele of interest, please contact us. |
| Antigens | |
|---|---|
| AFPCLIPCMV pp65CMV UL40EBVEBV BRLF1EBV BZLF-1EBV EBNAEBV EBNA3AEBV EBNA3BEBV EBNA3CEBV LMP1EBV LMP2EBV LMP2AEGF REWGAD65Glypican 3gp100HBVHER2HIV GagHPVHPV16 E7HPV16-E6HPV16-E7hTERTInfluenza HAInsBKRASKRASG12AKRASG12CKRASG12DKRASG12RKRASG12SKRASG12VMAGE-A1MAGE-A10MAGE-A2MAGE-A3MAGE-A4MBPNY-ESO-1OVAp53PAPPRAMEPSMARHAMM-R3RM9SSX-2SurvivinSurvivin MutSurvivin-2BTRP1Vaccinia virusWT-1 | New antigens are always in development. If you do not see the antigen of interest, please contact us. |
2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein（Fig B）and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was used to evaluate the binding activity
Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).
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