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Your Position: ホーム > Colony-Stimulating Factors and Receptors

Colony-Stimulating Factors and Receptors

Colony-Stimulating Factors and Receptors
INTRODUCTION
PRODUCT FEATURES
PRODUCT LIST
VERIFICATION DATA
Introduction
Colony-stimulating factors (CSFs) are of low molecular cytokines that stimulate the proliferation, differentiation, and colony formation of bone marrow hematopoietic stem cells. CSFs bind to receptor proteins on the surface of hematopoietic stem cells to activate downstream signals that promote the production of specific types of hematopoietic cells (usually leukocytes) in response to infection. Studies have shown that CSFs are also up-regulated in a variety of malignancies through both immune-dependent and non-immune-dependent pathways to promote tumor cell growth, invasion, and migration.
Schematic diagram of CSFs and their receptor families

Schematic diagram of CSFs and their receptor families

Different Types of CSF Targets

Different Types of CSF Targets

Macrophage colony-stimulating factor 1 (M-CSF) binds with its receptor (M-CSF R) to promote monocyte survival, promotes monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. It also initiates and enhances macrophage killing of tumor cells and microorganisms, modulates macrophage release of cytokines and other inflammatory modulators.

Different Types of CSF Targets

Granulocyte-macrophage colony stimulating factor 2 (GM-CSF), through binding to its receptor GM-CSF R, promotes cell proliferation, survival, differentiation and other biological effects. Aberrant expression of GM-CSF leads to excessive inflammation, pain, chemotaxis and tissue damage, which promotes the production of other pathogenic and inflammatory cytokines.

Different Types of CSF Targets

Granulocyte colony-stimulating factor (G-CSF) mainly acts on the proliferation, differentiation and activation of hematopoietic cells of the neutrophil lineage. In vitro, it stimulates neutrophil precursors of bone marrow hematopoietic cells to differentiate and proliferate to form mature granulocyte colonies. This improves phagocytosis of neutrophils and promotes superoxide production.

To support drug discovery targeting CSFs/CSF Rs, ACROBiosystems has developed a series of high-quality cytokines for immunization, antibody drug screening and characterization; helping you accelerate your antibody drug development process.
Product Features

HEK293 expressed, close to natural conformation

High biological activity verified by SPR/ BLI/ Cell Assays

Strict quality control to guarantee high batch-to-batch consistency

ELISA as QC test to guarantee high quality, free protocol shared

Supporting your Cell Culture

Supporting your Cell Culture
To support ongoing cell therapy manufacture and development, ACROBiosystems has developed a wide array of high-quality cytokines to culture immune cells, stem cells, organoids, and various other types of cells.

Our premium-grade growth factors, including CSFs, have:

Low Endotoxin (≤ 0.1 EU/µg)
Sterile, Animal-origin Free
Validated Bioactivity and Lot-to-Lot Consistency
Seamlessly transition to GMP-grade
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Product List
Molecule Cat. No. Species Product Description Preorder/Order
M-CSF MCF-H5247 Human Human M-CSF / CSF-1 Protein, His Tag

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MCF-H82E6 Human Biotinylated Human M-CSF / CSF-1 Protein, His,Avitag™

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M-CSF R CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (HPLC verified)

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CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin

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CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag

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CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)

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CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag

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CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag

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CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag

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CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag

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CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin

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CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag

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CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag

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GM-CSF GMF-H8214 Human Biotinylated Human GM-CSF Protein, epitope tag free, ultra sensitivity, primary amine labeling

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GM-CSF R alpha GRA-H5255 Human Human GM-CSF R alpha Protein, Fc Tag

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GRA-H52H7 Human Human GM-CSF R alpha Protein, His Tag (SPR verified)

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GMA-M52H3 Mouse Mouse GM-CSF R alpha Protein, His Tag

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G-CSF GCF-H5214 Human Human G-CSF Protein, premium grade

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G-CSF R GCR-H5223 Human Human G-CSF R / CD114 Protein, His Tag

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GCR-H5250 Human Human G-CSF R / CD114 Protein, Fc Tag

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GCR-H82E4 Human Biotinylated Human G-CSF R / CD114 Protein, Avitag™,His Tag (MALS verified)

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Verification Data

High biological activity (ELISA)

High biological activity (ELISA)

Immobilized Human M-CSF R, Fc Tag (Cat. No. CSR-H5258) at 2 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) with a linear range of 0.1-2 ng/mL (QC tested).

High biological activity (ELISA)

Immobilized Human GM-CSF, premium grade (Cat. No. GMF-H4214) at 1 μg/mL (100 μL/well) can bind Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) with a linear range of 0.5-16 ng/mL (QC tested).

High biological activity (ELISA)

Immobilized Human G-CSF, premium grade (Cat. No. GCF-H5214) at 2 μg/mL (100 μL/well) can bind Biotinylated Human G-CSF R, Avitag,His Tag (Cat. No. GCR-H82E4) with a linear range of 0.156-1.25 μg/mL (QC tested).

Affinity (SPR)

Affinity (SPR)

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Affinity (SPR)

Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) captured on CM5 Chip via anti-His antibody, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 16.1 nM as determined in SPR assay (Biacore T200) (QC tested).

Affinity (BLI)

Affinity (BLI)

Loaded Human M-CSF, His Tag (Cat. No. MCF-H5247) on HIS1K Biosensor, can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 3.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Affinity (BLI)

Loaded Biotinylated Human GM-CSF, epitope tag free, primary amine labeling (Cat. No. GMF-H8214) on SA Biosensor, can bind Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

High biological activity (Cell Base)
High biological activity (Cell Base)

Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).


High biological activity (Cell Base)

Human GM-CSF, premium grade(Cat. No. GMF-H4214) stimulates proliferation of GM-CSF-activated TF-1 cell. The specific activity of Human GM-CSF, premium grade is > 1.0ⅹ10^7 IU/mg , which is calibrated against human GM-CSF WHO International Standard (NIBSC code: 88/646) (QC tested).

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Reference
  • Hamilton J A. Colony-stimulating factors in inflammation and autoimmunity[J]. Nature Reviews Immunology, 2008, 8(7): 533-544.

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